Hideyuki Oguro, Ph.D.Assistant Professor, Department of Cell Biology
|M.S.||University of Tsukuba||Medical Sciences|
|Ph.D.||University of Tokyo||Pathology|
|Postdoctoral||University of Texas Southwestern Medical Center||Sean Morrison Laboratory|
|Name of Award/Honor||Awarding Organization|
|National Blood Foundation Scholar Award||National Blood Foundation|
|Scientific Research Grant||National Blood Foundation|
|Postdoctoral Fellowship for Research Abroad||Japan Society for the Promotion of Science|
|Promotion of Medical Science Foreign Study Grant||Kanae Foundation|
|Research Fellowship||Uehara Memorial Foundation|
|Young Investigator Award||Japan Society of Hematology|
|Research Fellowship for Young Scientists (PD)||Japan Society for the Promotion of Science|
|Research Fellowship for Young Scientists (DC1)||Japan Society for the Promotion of Science|
The Oguro laboratory investigates mechanisms that regulate blood-forming hematopoietic stem cell (HSC) development, self-renewal, and malignant transformation using mouse models, patient samples, and human induced pluripotent stem cells (hiPSCs).
HSCs are capable of both self-renewal and differentiation to maintain the entire blood/immune system throughout life. Our long-term research goal is to elucidate the molecular and cellular mechanisms of HSC function and translate our findings into therapies for diseases caused by insufficient hematopoiesis or hematologic malignancies.
Currently, my laboratory focuses on understanding how HSCs proliferate and mobilize in response to acute hematopoietic demands in mice and humans. Deciphering the molecular signals that allow HSCs to expand in vivo will be instructive for the development of clinical approaches to promote hematopoietic regeneration, such as after transplantation or blood loss, to increase the efficiency of collecting mobilized HSCs for transplantation, and to expand HSCs ex vivo. We are also seeking to understand how normal mechanisms that regulate HSC proliferation and mobilization in response to acute hematopoietic demands are exploited during the development and progression of hematopoietic malignancies, especially clonal hematopoiesis during aging.
Our parallel research objective is to generate long-term engraftable HSCs from hiPSCs by mimicking natural HSC development using a transgene-free and xeno-free method. This has the potential to provide a virtually unlimited supply of autologous HSCs for clinical transplantation to improve patient outcomes, and also offers diverse improved approaches for gene therapy, drug discovery, disease modeling, and in vitro modeling of human hematopoietic development.
Accepting Lab Rotation Students: Summer 2022, Fall 2022, and Spring 2023
A reference human induced pluripotent stem cell line for large-scale collaborative studies.
Cell stem cell 2022 Dec;29(12):1685-1702.e22
27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy.
The Journal of clinical investigation 2017 Sep;127(9):3392-3401
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal.
Nature 2015 Oct;526(7571):126-30
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
Nature 2014 Jan;505(7484):555-8
Lung bone marrow-derived hematopoietic progenitor cells enhance pulmonary fibrosis.
American journal of respiratory and critical care medicine 2013 Oct;188(8):976-84
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors.
Cell stem cell 2013 Jul;13(1):102-16
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
The Journal of experimental medicine 2012 Mar;209(3):445-54
Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells.
Leukemia 2011 Aug;25(8):1335-43
Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells.
Experimental hematology 2011 Jun;39(6):697-709.e5
Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.
Hepatology (Baltimore, Md.) 2010 Sep;52(3):1111-23
FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Experimental hematology 2010 Aug;38(8):696-706
Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells.
International journal of hematology 2010 May;91(4):611-9
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.
Cell stem cell 2010 Mar;6(3):279-86
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
Genes & development 2008 Apr;22(8):986-91
Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007 Jun;104(23):9764-9
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.
The Journal of experimental medicine 2006 Oct;203(10):2247-53
The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.
The Journal of biological chemistry 2006 May;281(19):13374-13381
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2006 May;103(18):7112-7
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1.
Immunity 2004 Dec;21(6):843-51
Generation of Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells.
Methods in molecular biology (Clifton, N.J.) 2019 Jan;245-257
The Roles of Cholesterol and Its Metabolites in Normal and Malignant Hematopoiesis.
Frontiers in endocrinology 2019 Jan;10204
Role of the polycomb group proteins in hematopoietic stem cells.
Development, growth & differentiation 2010 Aug;52(6):505-16
Life and death in hematopoietic stem cells.
Current opinion in immunology 2007 Oct;19(5):503-9
Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes.
International journal of hematology 2005 May;81(4):294-300
Polycomb gene product Bmi-1 regulates stem cell self-renewal.
Ernst Schering Research Foundation workshop 2005 Jan;(54):85-100
|Title or Abstract||Type||Sponsor/Event||Date/Year||Location|
|27-Hydroxycholesterol induces hematopoietic stem cell mobilization||Talk||The 95th Annual Meeting of the Japanese Biochemical Society||2022||Nagoya, Japan|
|Induction of Hematopoietic Stem Cell Proliferation and Mobilization by Estrogen Receptor Signaling||Talk||National Blood Foundation Research Symposium||2021||Virtual|
|Systemic regulation of hematopoietic stem cell division and mobilization||Talk||CANCER 2018||2018||Shatin, Hong Kong|
|27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis mediated by estrogen receptor alpha||Talk||59th American Society of Hematology Annual Meeting||2017||Atlanta, GA|
|27-hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy||Talk||15th Stem Cell Research Symposium||2017||Tokyo, Japan|
|Activation of hematopoietic stem cells by systemic signals||Talk||Chiba University||2017||Chiba, Japan|
|Activation of hematopoietic stem cells by systemic signals||Talk||University of Massachusetts Amherst||2016||Amherst, MA|
|Optimizing the culture medium that maintains mouse hematopoietic stem cells||Talk||International Society for Stem Cell Research 2016 Annual Meeting||2016||San Francisco, CA|