Hideyuki Oguro, Ph.D.Assistant Professor, Department of Cell Biology
|M.S.||University of Tsukuba||Medical Sciences|
|Ph.D.||University of Tokyo||Pathology|
|Postdoctoral||University of Texas Southwestern Medical Center||Sean Morrison Laboratory|
|Name of Award/Honor||Awarding Organization|
|National Blood Foundation Scholar Award||National Blood Foundation|
|Scientific Research Grant||National Blood Foundation|
|Postdoctoral Fellowship for Research Abroad||Japan Society for the Promotion of Science|
|Promotion of Medical Science Foreign Study Grant||Kanae Foundation|
|Research Fellowship||Uehara Memorial Foundation|
|Young Investigator Award||Japan Society of Hematology|
|Research Fellowship for Young Scientists (PD)||Japan Society for the Promotion of Science|
|Research Fellowship for Young Scientists (DC1)||Japan Society for the Promotion of Science|
The Oguro laboratory investigates mechanisms that regulate blood-forming hematopoietic stem cell (HSC) development, self-renewal, and malignant transformation using mouse models, patient samples, and human induced pluripotent stem cells (hiPSCs).
HSCs are capable of both self-renewal and differentiation to maintain the entire blood/immune system throughout life. Our long-term research goal is to elucidate the molecular and cellular mechanisms of HSC function and translate our findings into therapies for diseases caused by insufficient hematopoiesis or hematologic malignancies.
Currently, my laboratory focuses on understanding how HSCs proliferate and mobilize in response to acute hematopoietic demands in mice and humans. Deciphering the molecular signals that allow HSCs to expand in vivo will be instructive for the development of clinical approaches to promote hematopoietic regeneration, such as after transplantation or blood loss, to increase the efficiency of collecting mobilized HSCs for transplantation, and to expand HSCs ex vivo. We are also seeking to understand how normal mechanisms that regulate HSC proliferation and mobilization in response to acute hematopoietic demands are exploited during the development and progression of hematopoietic malignancies, especially clonal hematopoiesis during aging.
Our parallel research objective is to generate long-term engraftable HSCs from hiPSCs by mimicking natural HSC development using a transgene-free and xeno-free method. This has the potential to provide a virtually unlimited supply of autologous HSCs for clinical transplantation to improve patient outcomes, and also offers diverse improved approaches for gene therapy, drug discovery, disease modeling, and in vitro modeling of human hematopoietic development.
Accepting Lab Rotation Students: Summer 2022, Fall 2022, and Spring 2023
|Title or Abstract||Type||Sponsor/Event||Date/Year||Location|
|Induction of Hematopoietic Stem Cell Proliferation and Mobilization by Estrogen Receptor Signaling||Talk||National Blood Foundation Research Symposium||2021||Virtual|
|Systemic regulation of hematopoietic stem cell division and mobilization||Talk||CANCER 2018||2018||Shatin, Hong Kong|
|27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis mediated by estrogen receptor alpha||Talk||59th American Society of Hematology Annual Meeting||2017||Atlanta, GA|
|27-hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy||Talk||15th Stem Cell Research Symposium||2017||Tokyo, Japan|
|Activation of hematopoietic stem cells by systemic signals||Talk||Chiba University||2017||Chiba, Japan|
|Activation of hematopoietic stem cells by systemic signals||Talk||University of Massachusetts Amherst||2016||Amherst, MA|
|Optimizing the culture medium that maintains mouse hematopoietic stem cells||Talk||International Society for Stem Cell Research 2016 Annual Meeting||2016||San Francisco, CA|