Photo of Hideyuki  Oguro, Ph.D.

Hideyuki Oguro, Ph.D.

Assistant Professor, Department of Cell Biology
Academic Office Location:
Cell Biology
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3505
Email: oguro@uchc.edu
Website(s):

Oguro Lab Page

Cell Biology Graduate Program

Education
DegreeInstitutionMajor
B.S.Waseda UniversityBiology
M.S.University of TsukubaMedical Sciences
Ph.D.University of TokyoPathology

Post-Graduate Training
TrainingInstitutionSpecialty
University of Texas Southwestern Medical CenterSean Morrison Laboratory

Awards
Name of Award/HonorAwarding Organization
National Blood Foundation Scholar AwardNational Blood Foundation
Scientific Research GrantNational Blood Foundation
Postdoctoral Fellowship for Research AbroadJapan Society for the Promotion of Science
Promotion of Medical Science Foreign Study GrantKanae Foundation
Research FellowshipUehara Memorial Foundation
Young Investigator AwardJapan Society of Hematology
Research Fellowship for Young Scientists (PD)Japan Society for the Promotion of Science
Research Fellowship for Young Scientists (DC1)Japan Society for the Promotion of Science

The Oguro laboratory investigates mechanisms that regulate blood-forming hematopoietic stem cell (HSC) development, self-renewal, and malignant transformation using mouse models, patient samples, and human induced pluripotent stem cells (hiPSCs).


HSCs are capable of both self-renewal and differentiation to maintain the entire blood/immune system throughout life. Our long-term research goal is to elucidate the molecular and cellular mechanisms of HSC function and translate our findings into therapies for diseases caused by insufficient hematopoiesis or hematologic malignancies.


Currently, my laboratory focuses on understanding how HSCs proliferate and mobilize in response to acute hematopoietic demands in mice and humans. Deciphering the molecular signals that allow HSCs to expand in vivo will be instructive for the development of clinical approaches to promote hematopoietic regeneration, such as after transplantation or blood loss, to increase the efficiency of collecting mobilized HSCs for transplantation, and to expand HSCs ex vivo. We are also seeking to understand how normal mechanisms that regulate HSC proliferation and mobilization in response to acute hematopoietic demands are exploited during the development and progression of hematopoietic malignancies, especially clonal hematopoiesis during aging.


Our parallel research objective is to generate long-term engraftable HSCs from hiPSCs by mimicking natural HSC development using a transgene-free and xeno-free method. This has the potential to provide a virtually unlimited supply of autologous HSCs for clinical transplantation to improve patient outcomes, and also offers diverse improved approaches for gene therapy, drug discovery, disease modeling, and in vitro modeling of human hematopoietic development.

 


Accepting Lab Rotation Students: Summer 2022, Fall 2022, and Spring 2023

Journal Articles

Book Chapters

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Induction of Hematopoietic Stem Cell Proliferation and Mobilization by Estrogen Receptor SignalingTalkNational Blood Foundation Research Symposium2021Virtual
Systemic regulation of hematopoietic stem cell division and mobilizationTalkCANCER 2018 2018Shatin, Hong Kong
27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis mediated by estrogen receptor alphaTalk59th American Society of Hematology Annual Meeting2017Atlanta, GA
27-hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancyTalk15th Stem Cell Research Symposium2017Tokyo, Japan
Activation of hematopoietic stem cells by systemic signalsTalkChiba University2017Chiba, Japan
Activation of hematopoietic stem cells by systemic signalsTalkUniversity of Massachusetts Amherst2016Amherst, MA
Optimizing the culture medium that maintains mouse hematopoietic stem cellsTalkInternational Society for Stem Cell Research 2016 Annual Meeting2016San Francisco, CA