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Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define the molecular basis of the phosphoprotein phosphatase family regulation and substrate specificity
Wolfgang Peti, Sathish K.R. Padi, Rebecca Page Current Opinion in Structural Biology 2025 Feb;
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Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define the molecular basis of the phosphoprotein phosphatase family regulation and substrate specificity.
Peti, Wolfgang; Padi, Sathish K R; Page, Rebecca Current opinion in structural biology 2025 Feb;91102992
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Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Padi, Sathish K R; Vos, Margaret R; Godek, Rachel J; Fuller, James R; Kruse, Thomas; Hein, Jamin B; Nilsson, Jakob; Kelker, Matthew S; Page, Rebecca; Peti, Wolfgang Nature 2024 Jan;625(7993):195-203
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Synthesis of 2-Oxoquinoline Derivatives as Dual Pim and mTORC Protein Kinase Inhibitors.
Gnawali, Giri R; Okumura, Koichi; Perez, Karolina; Gallagher, Rosa; Wulfkuhle, Julia; Petricoin, Emanuel F; Padi, Sathish Kumar Reddy; Bearss, Jeremiah; He, Zhiyong; Wang, Wei; Kraft, Andrew S Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 2022 Jul;31(7):1154-1175
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The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer.
Singh, Neha; Ramnarine, Varune R; Song, Jin H; Pandey, Ritu; Padi, Sathish K R; Nouri, Mannan; Olive, Virginie; Kobelev, Maxim; Okumura, Koichi; McCarthy, David; Hanna, Michelle M; Mukherjee, Piali; Sun, Belinda; Lee, Benjamin R; Parker, J Brandon; Chakravarti, Debabrata; Warfel, Noel A; Zhou, Muhan; Bearss, Jeremiah J; Gibb, Ewan A; Alshalalfa, Mohammed; Karnes, R Jefferey; Small, Eric J; Aggarwal, Rahul; Feng, Felix; Wang, Yuzhuo; Buttyan, Ralph; Zoubeidi, Amina; Rubin, Mark; Gleave, Martin; Slack, Frank J; Davicioni, Elai; Beltran, Himisha; Collins, Colin; Kraft, Andrew S Nature communications 2021 Dec;12(1):7349
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"Root"ing for successful T-ALL treatment.
Padi, Sathish K R; Kraft, Andrew S Blood 2021 May;137(18):2422-2423
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EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics.
Bearss, Jeremiah J; Padi, Sathish Kr; Singh, Neha; Cardo-Vila, Marina; Song, Jin H; Mouneimne, Ghassan; Fernandes, Nikita; Li, Yang; Harter, Matthew R; Gard, Jaime Mc; Cress, Anne E; Peti, Wolfgang; Nelson, Andrew Dl; Buchan, J Ross; Kraft, Andrew S; Okumura, Koichi EMBO reports 2021 Apr;22(4):e50835
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PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.
Lim, James T; Singh, Neha; Leuvano, Libia A; Calvert, Valerie S; Petricoin, Emanuel F; Teachey, David T; Lock, Richard B; Padi, Megha; Kraft, Andrew S; Padi, Sathish K R Molecular cancer therapeutics 2020 Sep;19(9):1809-1821
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PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth.
Singh, Neha; Padi, Sathish K R; Bearss, Jeremiah J; Pandey, Ritu; Okumura, Koichi; Beltran, Himisha; Song, Jin H; Kraft, Andrew S; Olive, Virginie Molecular oncology 2020 May;14(5):974-990
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Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment (In Press, 2025)
Padi SKR*, Godek RJ*, Peti W and Page R. Nature Structural & Molecular Biology
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Molecular Mechanism of PP2A/B55α Phosphatase Inhibition by IER5
Ruili Cao; Daniel TD Jones; Li Pan; Annie Yang; Shumei Wang; Sathish K. R. Padi; Shaun Rawson; Jon C Aster; Stephen C Blacklow Cell Chemical Biology
