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Using hybrid methods to define the molecular basis of the phosphoprotein phosphatase (PPP) family regulation and substrate specificity
Peti, W., Padi, SKR, Page, R. Current Opinion in Structural Biology 2025 Feb;91102992
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Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define the molecular basis of the phosphoprotein phosphatase family regulation and substrate specificity.
Peti, Wolfgang; Padi, Sathish K R; Page, Rebecca Current opinion in structural biology 2025 Feb;91102992
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A protein phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome.
Choy, Meng S; Nguyen, Hieu T; Kumar, Ganesan S; Peti, Wolfgang; Kettenbach, Arminja N; Page, Rebecca Proceedings of the National Academy of Sciences of the United States of America 2024 Oct;121(44):e2415383121
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Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Padi, Sathish K R; Vos, Margaret R; Godek, Rachel J; Fuller, James R; Kruse, Thomas; Hein, Jamin B; Nilsson, Jakob; Kelker, Matthew S; Page, Rebecca; Peti, Wolfgang Nature 2024 Jan;625(7993):195-203
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The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange.
Choy, Meng S; Srivastava, Gautam; Robinson, Lucy C; Tatchell, Kelly; Page, Rebecca; Peti, Wolfgang The Journal of biological chemistry 2023 Nov;105515
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Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5.
Hunashal, Yamanappa; Kumar, Ganesan Senthil; Choy, Meng S; D'Andréa, Éverton D; Da Silva Santiago, Andre; Schoenle, Marta V; Desbonnet, Charlene; Arthur, Michel; Rice, Louis B; Page, Rebecca; Peti, Wolfgang Nature communications 2023 Jul;14(1):4268
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Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Srivastava, Gautam; Choy, Meng S; Bolik-Coulon, Nicolas; Page, Rebecca; Peti, Wolfgang Nature communications 2023 Mar;14(1):1798
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Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
Pavic, Karolina; Gupta, Nikhil; Omella, Judit Domènech; Derua, Rita; Aakula, Anna; Huhtaniemi, Riikka; Määttä, Juha A; Höfflin, Nico; Okkeri, Juha; Wang, Zhizhi; Kauko, Otto; Varjus, Roosa; Honkanen, Henrik; Abankwa, Daniel; Köhn, Maja; Hytönen, Vesa P; Xu, Wenqing; Nilsson, Jakob; Page, Rebecca; Janssens, Veerle; Leitner, Alexander; Westermarck, Jukka Nature communications 2023 Feb;14(1):1143
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The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs.
Srivastava, Gautam; Bajaj, Rakhi; Kumar, Ganesan Senthil; Gaudreau-Lapierre, Antoine; Nicolas, Hannah; Chamousset, Delphine; Kreitler, Dale; Peti, Wolfgang; Trinkle-Mulcahy, Laura; Page, Rebecca Cell Reports 2022 Nov;41(9):111726
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MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding.
Yu, Victor; Ronzone, Erik; Lord, Dana; Peti, Wolfgang; Page, Rebecca The Journal of biological chemistry 2022 Nov;298(11):102535
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Conserved conformational dynamics determine enzyme activity.
Torgeson, Kristiane R; Clarkson, Michael W; Granata, Daniele; Lindorff-Larsen, Kresten; Page, Rebecca; Peti, Wolfgang Science advances 2022 Aug;8(31):eabo5546
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Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex.
Zhang, Ruiyuan; Kumar, Ganesan Senthil; Hansen, Uwe; Zoccheddu, Martina; Sacchetti, Cristiano; Holmes, Zachary J; Lee, Megan C; Beckmann, Denise; Wen, Yutao; Mikulski, Zbigniew; Yang, Shen; Santelli, Eugenio; Page, Rebecca; Boin, Francesco; Peti, Wolfgang; Bottini, Nunzio JCI insight 2022 Apr;7(8):
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Degradation of the E. coli antitoxin MqsA by the proteolytic complex ClpXP is regulated by zinc occupancy and oxidation.
Vos, Margaret R; Piraino, Benjamin; LaBreck, Christopher J; Rahmani, Negar; Trebino, Catherine E; Schoenle, Marta; Peti, Wolfgang; Camberg, Jodi L; Page, Rebecca The Journal of biological chemistry 2022 Feb;101557
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The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1.
Singh, Jai Prakash; Li, Yang; Chen, Yi-Yun; Hsu, Shang-Te Danny; Page, Rebecca; Peti, Wolfgang; Meng, Tzu-Ching Nature communications 2022 Jan;13(1):94
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PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107.
Fowle, Holly; Zhao, Ziran; Xu, Qifang; Wasserman, Jason S; Wang, Xinru; Adeyemi, Mary; Feiser, Felicity; Kurimchak, Alison N; Atar, Diba; McEwan, Brennan C; Kettenbach, Arminja N; Page, Rebecca; Peti, Wolfgang; Dunbrack, Roland L; Graña, Xavier eLife 2021 Oct;10
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1H, 15N and 13C sequence specific backbone assignment of the MAP kinase binding domain of the dual specificity phosphatase 1 and its interaction with the MAPK p38.
Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang Biomolecular NMR assignments 2021 Jun;
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NMR Based SARS-CoV-2 Antibody Screening.
Schoenle, Marta V; Li, Yang; Yuan, Meng; Clarkson, Michael W; Wilson, Ian A; Peti, Wolfgang; Page, Rebecca Journal of the American Chemical Society 2021 Jun;143(21):7930-7934
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The interaction of p38 with its upstream kinase MKK6.
Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang Protein science : a publication of the Protein Society 2021 Feb;
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Cooperative dynamics across distinct structural elements regulate PTP1B activity.
Torgeson, Kristiane R; Clarkson, Michael W; Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang The Journal of biological chemistry 2020 Oct;295(40):13829-13837
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The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin.
Li, Yang; Sheftic, Sarah R; Grigoriu, Simina; Schwieters, Charles D; Page, Rebecca; Peti, Wolfgang Science advances 2020 Jul;6(27):
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A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
Wang, Xinru; Garvanska, Dimitriya H; Nasa, Isha; Ueki, Yumi; Zhang, Gang; Kettenbach, Arminja N; Peti, Wolfgang; Nilsson, Jakob; Page, Rebecca eLife 2020 Mar;9
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The mode of action of the Protein tyrosine phosphatase 1B inhibitor Ertiprotafib.
Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang PloS one 2020 Jan;15(10):e0240044
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Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates.
Brauer, Brooke L; Moon, Thomas M; Sheftic, Sarah R; Nasa, Isha; Page, Rebecca; Peti, Wolfgang; Kettenbach, Arminja N ACS chemical biology 2019 Dec;14(12):2672-2682
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Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.
Heroes, Ewald; Van der Hoeven, Gerd; Choy, Meng S; Garcia, Javier Del Pino; Ferreira, Mónica; Nys, Mieke; Derua, Rita; Beullens, Monique; Ulens, Chris; Peti, Wolfgang; Van Meervelt, Luc; Page, Rebecca; Bollen, Mathieu Structure (London, England : 1993) 2019 Mar;27(3):507-518.e5
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Preparation of Phosphorylated Proteins for NMR Spectroscopy.
Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang Methods in enzymology 2019 Jan;614187-205
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A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.
Lyons, Scott P; Jenkins, Nicole P; Nasa, Isha; Choy, Meng S; Adamo, Mark E; Page, Rebecca; Peti, Wolfgang; Moorhead, Greg B; Kettenbach, Arminja N Molecular & cellular proteomics : MCP 2018 Dec;17(12):2448-2461
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The structure of SDS22 provides insights into the mechanism of heterodimer formation with PP1.
Choy, Meng S; Bolik-Coulon, Nicolas; Archuleta, Tara L; Peti, Wolfgang; Page, Rebecca Acta crystallographica. Section F, Structural biology communications 2018 Dec;74(Pt 12):817-824
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The structures of penicillin-binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into β-lactam resistance.
Moon, Thomas M; D'Andréa, Éverton D; Lee, Christopher W; Soares, Alexei; Jakoncic, Jean; Desbonnet, Charlene; Garcia-Solache, Monica; Rice, Lou B; Page, Rebecca; Peti, Wolfgang The Journal of biological chemistry 2018 Nov;293(48):18574-18584
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Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.
Kumar, Ganesan Senthil; Choy, Meng S; Koveal, Dorothy M; Lorinsky, Michael K; Lyons, Scott P; Kettenbach, Arminja N; Page, Rebecca; Peti, Wolfgang Science advances 2018 Nov;4(11):eaau6044
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KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive.
Bajaj, Rakhi; Bollen, Mathieu; Peti, Wolfgang; Page, Rebecca Structure (London, England : 1993) 2018 Oct;26(10):1327-1336.e4
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Dynamic activation and regulation of the mitogen-activated protein kinase p38.
Kumar, Ganesan Senthil; Clarkson, Michael W; Kunze, Micha B A; Granata, Daniele; Wand, A Joshua; Lindorff-Larsen, Kresten; Page, Rebecca; Peti, Wolfgang Proceedings of the National Academy of Sciences of the United States of America 2018 May;115(18):4655-4660
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Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in Enterococcus faecalis.
Rice, Louis B; Desbonnet, Charlene; Tait-Kamradt, Amelia; Garcia-Solache, Monica; Lonks, John; Moon, Thomas M; D'Andréa, Éverton D; Page, Rebecca; Peti, Wolfgang mBio 2018 Apr;9(2):
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1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase.
Machado, Luciana E S F; Page, Rebecca; Peti, Wolfgang Biomolecular NMR assignments 2018 Apr;12(1):5-9
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A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor.
Zhang, Rui; Lord, Dana M; Bajaj, Rakhi; Peti, Wolfgang; Page, Rebecca; Sello, Jason K Nucleic acids research 2018 Feb;46(3):1501-1512
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PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.
Choy, Meng S; Swingle, Mark; D'Arcy, Brandon; Abney, Kevin; Rusin, Scott F; Kettenbach, Arminja N; Page, Rebecca; Honkanen, Richard E; Peti, Wolfgang Journal of the American Chemical Society 2017 Dec;139(49):17703-17706
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Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome.
Machado, Luciana E S F; Critton, David A; Page, Rebecca; Peti, Wolfgang ACS omega 2017 Nov;2(11):8313-8318
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The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation.
Machado, Luciana E S F; Shen, Tun-Li; Page, Rebecca; Peti, Wolfgang The Journal of biological chemistry 2017 May;292(21):8786-8796
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Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Choy, Meng S; Li, Yang; Machado, Luciana E S F; Kunze, Micha B A; Connors, Christopher R; Wei, Xingyu; Lindorff-Larsen, Kresten; Page, Rebecca; Peti, Wolfgang Molecular cell 2017 Feb;65(4):644-658.e5
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Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.
Sheftic, Sarah R; Page, Rebecca; Peti, Wolfgang Scientific reports 2016 Dec;638920
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Expanding the PP2A Interactome by Defining a B56-Specific SLiM.
Wang, Xinru; Bajaj, Rakhi; Bollen, Mathieu; Peti, Wolfgang; Page, Rebecca Structure (London, England : 1993) 2016 Dec;24(12):2174-2181
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Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans.
Chen, Emily; Choy, Meng S; Petrényi, Katalin; Kónya, Zoltán; Erdodi, Ferenc; Dombrádi, Viktor; Peti, Wolfgang; Page, Rebecca mBio 2016 Aug;7(4):
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The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.
Kumar, Ganesan Senthil; Gokhan, Ezgi; De Munter, Sofie; Bollen, Mathieu; Vagnarelli, Paola; Peti, Wolfgang; Page, Rebecca eLife 2016 Aug;5
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NMR Spectroscopy to Study MAP Kinase Binding to MAP Kinase Phosphatases.
Peti, Wolfgang; Page, Rebecca Methods in molecular biology (Clifton, N.J.) 2016 Jan;1447181-96
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The MqsR/MqsA toxin/antitoxin system protects Escherichia coli during bile acid stress.
Kwan, Brian W; Lord, Dana M; Peti, Wolfgang; Page, Rebecca; Benedik, Michael J; Wood, Thomas K Environmental microbiology 2015 Sep;17(9):3168-81
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PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.
Krishnan, Navasona; Krishnan, Keerthi; Connors, Christopher R; Choy, Meng S; Page, Rebecca; Peti, Wolfgang; Van Aelst, Linda; Shea, Stephen D; Tonks, Nicholas K The Journal of clinical investigation 2015 Aug;125(8):3163-77
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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.
Choy, Meng S; Yusoff, Permeen; Lee, Irene C; Newton, Jocelyn C; Goh, Catherine W; Page, Rebecca; Shenolikar, Shirish; Peti, Wolfgang Cell reports 2015 Jun;11(12):1885-91
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Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites.
Peti, Wolfgang; Page, Rebecca Bioorganic & medicinal chemistry 2015 Jun;23(12):2781-5
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McbR/YncC: implications for the mechanism of ligand and DNA binding by a bacterial GntR transcriptional regulator involved in biofilm formation.
Lord, Dana M; Uzgoren Baran, Ayse; Soo, Valerie W C; Wood, Thomas K; Peti, Wolfgang; Page, Rebecca Biochemistry 2014 Nov;53(46):7223-31
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Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Krishnan, Navasona; Koveal, Dorothy; Miller, Daniel H; Xue, Bin; Akshinthala, Sai Dipikaa; Kragelj, Jaka; Jensen, Malene Ringkjøbing; Gauss, Carla-Maria; Page, Rebecca; Blackledge, Martin; Muthuswamy, Senthil K; Peti, Wolfgang; Tonks, Nicholas K Nature chemical biology 2014 Jul;10(7):558-66
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Sequence-specific backbone ¹H, ¹³C and ¹⁵N assignments of the 34 kDa catalytic domain of PTPN5 (STEP).
Francis, Dana M; Page, Rebecca; Peti, Wolfgang Biomolecular NMR assignments 2014 Apr;8(1):185-8
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Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
Choy, Meng S; Hieke, Martina; Kumar, Ganesan Senthil; Lewis, Greyson R; Gonzalez-DeWhitt, Kristofer R; Kessler, Rene P; Stein, Benjamin J; Hessenberger, Manuel; Nairn, Angus C; Peti, Wolfgang; Page, Rebecca Proceedings of the National Academy of Sciences of the United States of America 2014 Mar;111(11):4097-102
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BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH.
Lord, Dana M; Baran, Ayse Uzgoren; Wood, Thomas K; Peti, Wolfgang; Page, Rebecca PloS one 2014 Jan;9(9):e105751
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Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2.
Francis, Dana M; Koveal, Dorothy; Tortajada, Antoni; Page, Rebecca; Peti, Wolfgang PloS one 2014 Jan;9(3):e91934
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Ligand binding reduces conformational flexibility in the active site of tyrosine phosphatase related to biofilm formation A (TpbA) from Pseudomonasaeruginosa.
Koveal, Dorothy; Clarkson, Michael W; Wood, Thomas K; Page, Rebecca; Peti, Wolfgang Journal of molecular biology 2013 Jun;425(12):2219-31
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Backbone and sidechain (1)H, (15)N and (13)C assignments of Tyrosine Phosphatase related to Biofilm formation A (TpbA) of Pseudomonas aeruginosa.
Koveal, Dorothy; Jayasundera, Thusitha B; Wood, Thomas K; Peti, Wolfgang; Page, Rebecca Biomolecular NMR assignments 2013 Apr;7(1):57-9
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Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation.
Brown, Breann L; Wood, Thomas K; Peti, Wolfgang; Page, Rebecca The Journal of biological chemistry 2011 Jan;286(3):2285-96
