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Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Padi, Sathish K R; Vos, Margaret R; Godek, Rachel J; Fuller, James R; Kruse, Thomas; Hein, Jamin B; Nilsson, Jakob; Kelker, Matthew S; Page, Rebecca; Peti, Wolfgang Nature 2024 Jan;625(7993):195-203
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The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange.
Choy, Meng S; Srivastava, Gautam; Robinson, Lucy C; Tatchell, Kelly; Page, Rebecca; Peti, Wolfgang The Journal of biological chemistry 2023 Nov;105515
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Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5.
Hunashal, Yamanappa; Kumar, Ganesan Senthil; Choy, Meng S; D'Andréa, Éverton D; Da Silva Santiago, Andre; Schoenle, Marta V; Desbonnet, Charlene; Arthur, Michel; Rice, Louis B; Page, Rebecca; Peti, Wolfgang Nature communications 2023 Jul;14(1):4268
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Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
Srivastava, Gautam; Choy, Meng S; Bolik-Coulon, Nicolas; Page, Rebecca; Peti, Wolfgang Nature communications 2023 Mar;14(1):1798
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Penicillin-Binding Proteins and Alternative Dual-Beta-Lactam Combinations for Serious Enterococcus faecalis Infections with Elevated Penicillin MICs.
Cusumano, Jaclyn A; Daffinee, Kathryn E; Ugalde-Silva, Paul; Peti, Wolfgang; Arthur, Michel; Desbonnet, Charlene; Rice, Louis B; LaPlante, Kerry L; García-Solache, Mónica Antimicrobial agents and chemotherapy 2023 Feb;67(2):e0087122
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Active-site cysteine 215 sulfonation targets protein tyrosine phosphatase PTP1B for Cullin1 E3 ligase-mediated degradation.
Yang, Chun-Yi; Yang, Chiu-Fen; Tang, Xiao-Fang; Machado, Luciana E S F; Singh, Jai Prakash; Peti, Wolfgang; Chen, Chien-Sheng; Meng, Tzu-Ching Free radical biology & medicine 2022 Nov;194147-159
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The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs.
Srivastava, Gautam; Bajaj, Rakhi; Kumar, Ganesan Senthil; Gaudreau-Lapierre, Antoine; Nicolas, Hannah; Chamousset, Delphine; Kreitler, Dale; Peti, Wolfgang; Trinkle-Mulcahy, Laura; Page, Rebecca Cell Reports 2022 Nov;41(9):111726
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MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding.
Yu, Victor; Ronzone, Erik; Lord, Dana; Peti, Wolfgang; Page, Rebecca The Journal of biological chemistry 2022 Nov;298(11):102535
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Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex.
Zhang, Ruiyuan; Kumar, Ganesan Senthil; Hansen, Uwe; Zoccheddu, Martina; Sacchetti, Cristiano; Holmes, Zachary J; Lee, Megan C; Beckmann, Denise; Wen, Yutao; Mikulski, Zbigniew; Yang, Shen; Santelli, Eugenio; Page, Rebecca; Boin, Francesco; Peti, Wolfgang; Bottini, Nunzio JCI insight 2022 Apr;7(8):
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Degradation of the E. coli antitoxin MqsA by the proteolytic complex ClpXP is regulated by zinc occupancy and oxidation.
Vos, Margaret R; Piraino, Benjamin; LaBreck, Christopher J; Rahmani, Negar; Trebino, Catherine E; Schoenle, Marta; Peti, Wolfgang; Camberg, Jodi L; Page, Rebecca The Journal of biological chemistry 2022 Feb;101557
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The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1.
Singh, Jai Prakash; Li, Yang; Chen, Yi-Yun; Hsu, Shang-Te Danny; Page, Rebecca; Peti, Wolfgang; Meng, Tzu-Ching Nature communications 2022 Jan;13(1):94
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Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity.
Singh, Jai Prakash; Lin, Meng-Jung; Hsu, Shu-Fang; Peti, Wolfgang; Lee, Cheng-Chung; Meng, Tzu-Ching Biochemistry 2021 Dec;60(51):3856-3867
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PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107.
Fowle, Holly; Zhao, Ziran; Xu, Qifang; Wasserman, Jason S; Wang, Xinru; Adeyemi, Mary; Feiser, Felicity; Kurimchak, Alison N; Atar, Diba; McEwan, Brennan C; Kettenbach, Arminja N; Page, Rebecca; Peti, Wolfgang; Dunbrack, Roland L; Graña, Xavier eLife 2021 Oct;10
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Design, synthesis, kinetic, molecular dynamics, and hypoglycemic effect characterization of new and potential selective benzimidazole derivatives as Protein Tyrosine Phosphatase 1B inhibitors.
Campos-Almazán, Mara Ibeth; Flores-Ramos, Miguel; Hernández-Campos, Alicia; Castillo, Rafael; Sierra-Campos, Erick; Torgeson, Kristiane; Peti, Wolfgang; Valdez-Solana, Mónica; Oria-Hernández, Jesús; Méndez, Sara T; Castillo-Villanueva, Adriana; Jiménez-de Jesús, Hugo; Avitia-Domínguez, Claudia; Téllez-Valencia, Alfredo Bioorganic & medicinal chemistry 2021 Sep;48116418
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1H, 15N and 13C sequence specific backbone assignment of the MAP kinase binding domain of the dual specificity phosphatase 1 and its interaction with the MAPK p38.
Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang Biomolecular NMR assignments 2021 Jun;
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NMR Based SARS-CoV-2 Antibody Screening.
Schoenle, Marta V; Li, Yang; Yuan, Meng; Clarkson, Michael W; Wilson, Ian A; Peti, Wolfgang; Page, Rebecca Journal of the American Chemical Society 2021 Jun;143(21):7930-7934
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EDC3 phosphorylation regulates growth and invasion through controlling P-body formation and dynamics.
Bearss, Jeremiah J; Padi, Sathish Kr; Singh, Neha; Cardo-Vila, Marina; Song, Jin H; Mouneimne, Ghassan; Fernandes, Nikita; Li, Yang; Harter, Matthew R; Gard, Jaime Mc; Cress, Anne E; Peti, Wolfgang; Nelson, Andrew Dl; Buchan, J Ross; Kraft, Andrew S; Okumura, Koichi EMBO reports 2021 Apr;22(4):e50835
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The interaction of p38 with its upstream kinase MKK6.
Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang Protein science : a publication of the Protein Society 2021 Feb;
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Structural Optimization of 2,3-Dihydro-1H-cyclopenta[b]quinolines Targeting the Noncatalytic RVxF Site of Protein Phosphatase 1 for HIV-1 Inhibition.
Lin, Xionghao; Sajith, Ayyiliath M; Wang, Songping; Kumari, Namita; Choy, Meng S; Ahmad, Asrar; Cadet, Dana R; Gu, Xinbin; Ivanov, Andrey I; Peti, Wolfgang; Kulkarni, Amol; Nekhai, Sergei ACS infectious diseases 2020 Dec;6(12):3190-3211
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Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Kirsch, Klára; Zeke, András; Toke, Orsolya; Sok, Péter; Sethi, Ashish; Sebo, Anna; Kumar, Ganesan Senthil; Egri, Péter; Póti, Ádám L; Gooley, Paul; Peti, Wolfgang; Bento, Isabel; Alexa, Anita; Reményi, Attila Nature communications 2020 Nov;11(1):5769
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MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Sok, Péter; Gógl, Gergo; Kumar, Ganesan Senthil; Alexa, Anita; Singh, Neha; Kirsch, Klára; Sebo, Anna; Drahos, László; Gáspári, Zoltán; Peti, Wolfgang; Reményi, Attila Structure (London, England : 1993) 2020 Oct;28(10):1101-1113.e5
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Cooperative dynamics across distinct structural elements regulate PTP1B activity.
Torgeson, Kristiane R; Clarkson, Michael W; Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang The Journal of biological chemistry 2020 Oct;295(40):13829-13837
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The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin.
Li, Yang; Sheftic, Sarah R; Grigoriu, Simina; Schwieters, Charles D; Page, Rebecca; Peti, Wolfgang Science advances 2020 Jul;6(27):
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A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
Wang, Xinru; Garvanska, Dimitriya H; Nasa, Isha; Ueki, Yumi; Zhang, Gang; Kettenbach, Arminja N; Peti, Wolfgang; Nilsson, Jakob; Page, Rebecca eLife 2020 Mar;9
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The mode of action of the Protein tyrosine phosphatase 1B inhibitor Ertiprotafib.
Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang PloS one 2020 Jan;15(10):e0240044
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Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates.
Brauer, Brooke L; Moon, Thomas M; Sheftic, Sarah R; Nasa, Isha; Page, Rebecca; Peti, Wolfgang; Kettenbach, Arminja N ACS chemical biology 2019 Dec;14(12):2672-2682
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Retinoic Acid Binding Leads to CRABP2 Rigidification and Dimerization.
Lixa, Carolina; Clarkson, Michael W; Iqbal, Anwar; Moon, Thomas M; Almeida, Fabio C L; Peti, Wolfgang; Pinheiro, Anderson S Biochemistry 2019 Oct;58(41):4183-4194
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SDS22 selectively recognizes and traps metal-deficient inactive PP1.
Choy, Meng S; Moon, Thomas M; Ravindran, Rini; Bray, Johnny A; Robinson, Lucy C; Archuleta, Tara L; Shi, Wuxian; Peti, Wolfgang; Tatchell, Kelly; Page, Rebecca Proceedings of the National Academy of Sciences of the United States of America 2019 Oct;116(41):20472-20481
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Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin.
Hendus-Altenburger, Ruth; Wang, Xinru; Sjøgaard-Frich, Lise M; Pedraz-Cuesta, Elena; Sheftic, Sarah R; Bendsøe, Anne H; Page, Rebecca; Kragelund, Birthe B; Pedersen, Stine F; Peti, Wolfgang Nature communications 2019 Aug;10(1):3489
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Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.
Heroes, Ewald; Van der Hoeven, Gerd; Choy, Meng S; Garcia, Javier Del Pino; Ferreira, Mónica; Nys, Mieke; Derua, Rita; Beullens, Monique; Ulens, Chris; Peti, Wolfgang; Van Meervelt, Luc; Page, Rebecca; Bollen, Mathieu Structure (London, England : 1993) 2019 Mar;27(3):507-518.e5
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ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail.
Bertran, M Teresa; Mouilleron, Stéphane; Zhou, Yanxiang; Bajaj, Rakhi; Uliana, Federico; Kumar, Ganesan Senthil; van Drogen, Audrey; Lee, Rebecca; Banerjee, Jennifer J; Hauri, Simon; O'Reilly, Nicola; Gstaiger, Matthias; Page, Rebecca; Peti, Wolfgang; Tapon, Nicolas Nature communications 2019 Feb;10(1):771
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Preparation of Phosphorylated Proteins for NMR Spectroscopy.
Kumar, Ganesan Senthil; Page, Rebecca; Peti, Wolfgang Methods in enzymology 2019 Jan;614187-205
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Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition.
Lin, Xionghao; Ammosova, Tatiana; Choy, Meng S; Pietzsch, Colette A; Ivanov, Andrey; Ahmad, Asrar; Saygideger, Yasemin; Kumari, Namita; Kovalskyy, Dmytro; Üren, Aykut; Peti, Wolfgang; Bukreyev, Alexander; Nekhai, Sergei Frontiers in microbiology 2019 Jan;102145
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A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.
Lyons, Scott P; Jenkins, Nicole P; Nasa, Isha; Choy, Meng S; Adamo, Mark E; Page, Rebecca; Peti, Wolfgang; Moorhead, Greg B; Kettenbach, Arminja N Molecular & cellular proteomics : MCP 2018 Dec;17(12):2448-2461
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The structure of SDS22 provides insights into the mechanism of heterodimer formation with PP1.
Choy, Meng S; Bolik-Coulon, Nicolas; Archuleta, Tara L; Peti, Wolfgang; Page, Rebecca Acta crystallographica. Section F, Structural biology communications 2018 Dec;74(Pt 12):817-824
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The structures of penicillin-binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into β-lactam resistance.
Moon, Thomas M; D'Andréa, Éverton D; Lee, Christopher W; Soares, Alexei; Jakoncic, Jean; Desbonnet, Charlene; Garcia-Solache, Monica; Rice, Lou B; Page, Rebecca; Peti, Wolfgang The Journal of biological chemistry 2018 Nov;293(48):18574-18584
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Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.
Kumar, Ganesan Senthil; Choy, Meng S; Koveal, Dorothy M; Lorinsky, Michael K; Lyons, Scott P; Kettenbach, Arminja N; Page, Rebecca; Peti, Wolfgang Science advances 2018 Nov;4(11):eaau6044
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KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive.
Bajaj, Rakhi; Bollen, Mathieu; Peti, Wolfgang; Page, Rebecca Structure (London, England : 1993) 2018 Oct;26(10):1327-1336.e4
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A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.
Crespillo-Casado, Ana; Claes, Zander; Choy, Meng S; Peti, Wolfgang; Bollen, Mathieu; Ron, David The Journal of biological chemistry 2018 May;293(20):7766-7776
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Dynamic activation and regulation of the mitogen-activated protein kinase p38.
Kumar, Ganesan Senthil; Clarkson, Michael W; Kunze, Micha B A; Granata, Daniele; Wand, A Joshua; Lindorff-Larsen, Kresten; Page, Rebecca; Peti, Wolfgang Proceedings of the National Academy of Sciences of the United States of America 2018 May;115(18):4655-4660
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Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in Enterococcus faecalis.
Rice, Louis B; Desbonnet, Charlene; Tait-Kamradt, Amelia; Garcia-Solache, Monica; Lonks, John; Moon, Thomas M; D'Andréa, Éverton D; Page, Rebecca; Peti, Wolfgang mBio 2018 Apr;9(2):
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1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase.
Machado, Luciana E S F; Page, Rebecca; Peti, Wolfgang Biomolecular NMR assignments 2018 Apr;12(1):5-9
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A peculiar IclR family transcription factor regulates para-hydroxybenzoate catabolism in Streptomyces coelicolor.
Zhang, Rui; Lord, Dana M; Bajaj, Rakhi; Peti, Wolfgang; Page, Rebecca; Sello, Jason K Nucleic acids research 2018 Feb;46(3):1501-1512
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PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.
Choy, Meng S; Swingle, Mark; D'Arcy, Brandon; Abney, Kevin; Rusin, Scott F; Kettenbach, Arminja N; Page, Rebecca; Honkanen, Richard E; Peti, Wolfgang Journal of the American Chemical Society 2017 Dec;139(49):17703-17706
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Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome.
Machado, Luciana E S F; Critton, David A; Page, Rebecca; Peti, Wolfgang ACS omega 2017 Nov;2(11):8313-8318
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The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation.
Machado, Luciana E S F; Shen, Tun-Li; Page, Rebecca; Peti, Wolfgang The Journal of biological chemistry 2017 May;292(21):8786-8796
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Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.
Choy, Meng S; Li, Yang; Machado, Luciana E S F; Kunze, Micha B A; Connors, Christopher R; Wei, Xingyu; Lindorff-Larsen, Kresten; Page, Rebecca; Peti, Wolfgang Molecular cell 2017 Feb;65(4):644-658.e5
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Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.
Sheftic, Sarah R; Page, Rebecca; Peti, Wolfgang Scientific reports 2016 Dec;638920
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Expanding the PP2A Interactome by Defining a B56-Specific SLiM.
Wang, Xinru; Bajaj, Rakhi; Bollen, Mathieu; Peti, Wolfgang; Page, Rebecca Structure (London, England : 1993) 2016 Dec;24(12):2174-2181
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Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans.
Chen, Emily; Choy, Meng S; Petrényi, Katalin; Kónya, Zoltán; Erdodi, Ferenc; Dombrádi, Viktor; Peti, Wolfgang; Page, Rebecca mBio 2016 Aug;7(4):
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The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.
Kumar, Ganesan Senthil; Gokhan, Ezgi; De Munter, Sofie; Bollen, Mathieu; Vagnarelli, Paola; Peti, Wolfgang; Page, Rebecca eLife 2016 Aug;5
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NMR Spectroscopy to Study MAP Kinase Binding to MAP Kinase Phosphatases.
Peti, Wolfgang; Page, Rebecca Methods in molecular biology (Clifton, N.J.) 2016 Jan;1447181-96
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The MqsR/MqsA toxin/antitoxin system protects Escherichia coli during bile acid stress.
Kwan, Brian W; Lord, Dana M; Peti, Wolfgang; Page, Rebecca; Benedik, Michael J; Wood, Thomas K Environmental microbiology 2015 Sep;17(9):3168-81
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PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.
Krishnan, Navasona; Krishnan, Keerthi; Connors, Christopher R; Choy, Meng S; Page, Rebecca; Peti, Wolfgang; Van Aelst, Linda; Shea, Stephen D; Tonks, Nicholas K The Journal of clinical investigation 2015 Aug;125(8):3163-77
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Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.
Choy, Meng S; Yusoff, Permeen; Lee, Irene C; Newton, Jocelyn C; Goh, Catherine W; Page, Rebecca; Shenolikar, Shirish; Peti, Wolfgang Cell reports 2015 Jun;11(12):1885-91
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Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites.
Peti, Wolfgang; Page, Rebecca Bioorganic & medicinal chemistry 2015 Jun;23(12):2781-5
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McbR/YncC: implications for the mechanism of ligand and DNA binding by a bacterial GntR transcriptional regulator involved in biofilm formation.
Lord, Dana M; Uzgoren Baran, Ayse; Soo, Valerie W C; Wood, Thomas K; Peti, Wolfgang; Page, Rebecca Biochemistry 2014 Nov;53(46):7223-31
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Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.
Krishnan, Navasona; Koveal, Dorothy; Miller, Daniel H; Xue, Bin; Akshinthala, Sai Dipikaa; Kragelj, Jaka; Jensen, Malene Ringkjøbing; Gauss, Carla-Maria; Page, Rebecca; Blackledge, Martin; Muthuswamy, Senthil K; Peti, Wolfgang; Tonks, Nicholas K Nature chemical biology 2014 Jul;10(7):558-66
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Sequence-specific backbone ¹H, ¹³C and ¹⁵N assignments of the 34 kDa catalytic domain of PTPN5 (STEP).
Francis, Dana M; Page, Rebecca; Peti, Wolfgang Biomolecular NMR assignments 2014 Apr;8(1):185-8
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Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.
Choy, Meng S; Hieke, Martina; Kumar, Ganesan Senthil; Lewis, Greyson R; Gonzalez-DeWhitt, Kristofer R; Kessler, Rene P; Stein, Benjamin J; Hessenberger, Manuel; Nairn, Angus C; Peti, Wolfgang; Page, Rebecca Proceedings of the National Academy of Sciences of the United States of America 2014 Mar;111(11):4097-102
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BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH.
Lord, Dana M; Baran, Ayse Uzgoren; Wood, Thomas K; Peti, Wolfgang; Page, Rebecca PloS one 2014 Jan;9(9):e105751
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Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2.
Francis, Dana M; Koveal, Dorothy; Tortajada, Antoni; Page, Rebecca; Peti, Wolfgang PloS one 2014 Jan;9(3):e91934
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Ligand binding reduces conformational flexibility in the active site of tyrosine phosphatase related to biofilm formation A (TpbA) from Pseudomonasaeruginosa.
Koveal, Dorothy; Clarkson, Michael W; Wood, Thomas K; Page, Rebecca; Peti, Wolfgang Journal of molecular biology 2013 Jun;425(12):2219-31
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Backbone and sidechain (1)H, (15)N and (13)C assignments of Tyrosine Phosphatase related to Biofilm formation A (TpbA) of Pseudomonas aeruginosa.
Koveal, Dorothy; Jayasundera, Thusitha B; Wood, Thomas K; Peti, Wolfgang; Page, Rebecca Biomolecular NMR assignments 2013 Apr;7(1):57-9
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Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation.
Brown, Breann L; Wood, Thomas K; Peti, Wolfgang; Page, Rebecca The Journal of biological chemistry 2011 Jan;286(3):2285-96
