Photo of Lynn  Puddington, Ph.D.

Lynn Puddington, Ph.D.

Associate Professor of Immunology and Medicine
Chair, Graduate Programs Committee
Academic Office Location:
Immunology
UConn Health
263 Farmington Avenue
Farmington, CT 06030-1319
Phone: 860-679-4655
Fax: 860-679-1868
Website(s):

Immunology Graduate Program

Department of Immunology

Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Executive Committee of the Graduate School: The Executive Committee is the steering committee for the Graduate School. It advises the Vice Provost for Graduate Education on matters of policy and regulatory interpretation, approves plans of study and dissertation prospectuses, and considers on the basis of academic merit proposals to modify or to create fields of study and areas of concentration.Advisory CommitteeMember (Elected by the Graduate Faculty Council)University20182021
UConn School of Medicine Education Council: the Education Council formulates policies and plans for all educational activities sponsored by the School of MedicineEducation CommitteeMember (Elected by the Paid and Affiliated Faculty of the SOM)UConn HealthUniversity20182021
NIH, Standing Member - Immunity and Host Defense Study SectionStudy SectionReviewerExternalNational20152020
Medical and Dental Student Research Day (annual conference)Workshop/ConferenceCo-Chair (School of Medicine)UConn HealthUniversity20152020
Curriculum Development, Operations, Grading Committees, Scholarship & Discovery, VITAL, Stage 1Education CommitteeChair - S&D; Member - othersUniversity20142021
American Association for the Advancement of ScienceProfessional/Scientific OrganizationMemberExternalInternational20122021
Council on Education: The Council oversees the development, modification, evaluation and measurement of educational programs at all levels: predoctoral, postdoctoral, continuing, and other related programs in the School of Dental Medicine. The Council is, thus, authorized to recommend policies and procedures for educational programs, admission, evaluation and promotion of students.Education CommitteeMember (Appointed SDM)University20082021
Society of Mucosal ImmunologyProfessional/Scientific OrganizationMemberInternational20042021
American Association of ImmunologistsProfessional/Scientific OrganizationMemberExternalInternational19982021
Institutional Animal Care and Use Committee: Includes meetings, advising investigators, providing merit reviews and special subcommittees. Also post-approval animal welfare support (PAWS) inspections on a rotating basis.Research CommitteeMember (Appointed Assoc VP for Reseach, Research Integrity & Reg Affairs)University19962021
The overall goal of the research ongoing in my laboratory is to elucidate the contribution of maternal antigen or immune status in the susceptibility or resistance to development of allergic airway disease in offspring. It is evident from epidemiological studies that the risk for childhood asthma is increased by having a positive family history of asthma. In particular, allergic sensitization of the newborn is closely linked to maternal but not to paternal allergies. Our focus is on early life events (either pre-natal or early post-natal) that can result in T and B cell tolerance or immunity. Our hypothesis is that the environment in neonatal mice (determined by maternal immunity or passive transfer of antigen) is critical to immunological outcome, having life-long influences on development of immune responsiveness. We are identifying the cells responsible and the mechanisms by which they dictate functional commitment of the neonate to the development of, or protection from, atopy.


One strategy we are undertaking to advance this work is to characterize the antigen-presenting environment in pre- and post-natal life, with the focus on defining factors that dictate whether exposure to allergen in early life induces T cell sensitization or tolerance. The thinking is that in certain circumstances, T cell sensitization can occur in utero or in early post-natal life and that factors responsible for these circumstances have increased in the past 20 years. It has been proposed that this could explain the increased incidence of asthma and other inflammatory diseases. The challenge for scientists is to identify factors that control this process, with the ultimate goal of developing therapeutic strategies to reverse the progressive increase in disease. Our studies are focused on antigen-presenting cells such as dendritic cells (DCs) or macrophages, as they are known to direct the T cell responses to antigen throughout life, presumably including the pre- and post-natal period. In addition, we have developed transgenic models for evaluating T cell functional capacity at different ages, and in different environmental conditions, e.g. spleen or lymph node vs. lung or intestine in naïve mice or those with allergic airway disease. Our findings support the concept that it is not only the innate immune system that directs T cell responses, but also that T cell responses shape the development of the innate immune system.


Not accepting lab rotation students at this time

Journal Articles

Book Chapters

  • Development of intestinal intraepithelial lymphocytes.
    Lefrançois, L., Fuller, B., Olson, S. and Puddington, L. Essentials of Mucosal Immunology 1996 Jan;183-193

Editorials

Erratums

Reviews

Short Surveys