Abhijit Rath, Ph.D.Assistant Professor, Molecular Oncology
Facilitating CRISPR based functional genomics approaches, Modulation of DNA double-strand break repair to enable precision gene editing.
|Ph.D.||Louisiana State University Health Center||Biochemistry & Molecular Biology|
|B.V.M.S.||Orissa University of Agriculture & Technology||Veterinary Science & Animal Husbandry|
|Fellowship||Louisiana State University Health Center||Carroll Feist Pre-doctoral Research|
|Name of Award/Honor||Awarding Organization|
|Full Scholarship for the “Workshop on 3D Genome Mapping Technology-ChIAPET”|
|Second Place in “Outstanding Biochemistry Student” Award Competition|
|First Place in Ray A. Barlow Excellence in Cancer Research Award in Barlow Symposium|
My current research focuses on modeling Lynch syndrome (LS) associated DNA mismatch repair gene variants in human embryonic stem cells using CRISPR-Cas gene editing. We aim to gather variant specific functional data to better inform the clinical diagnosis and stratification of LS patients. Over the course of the last few years, we have optimized CRISPR based genome engineering to serve as a highly efficient tool to site-specifically incorporate genomic single nucleotide variant change. We aim to improve the throughput of this powerful reverse genetic approach for large scale functional genomics studies and lessen the existing technical constraints. Specifically, we aim to explore novel methodologies to improve homology directed repair outcomes for CRISPR-Cas induced DNA double-strand breaks.