Abhijit Rath, Ph.D.Instructor of Molecular Oncology
Facilitating CRISPR based functional genomics approaches, modulation of DNA double-strand break repair to enable precision gene editing.
|Ph.D.||LSU Health Shreveport||Biochemistry and Molecular Biology|
|B.VSc. & A.H.||Orissa University of Agriculture & Technology||Veterinary Science and Animal Husbandry|
|Postdoctoral||UConn School of Medicine||Genetic Predisposition to Colorectal Cancer|
|Name of Award/Honor||Awarding Organization|
|Full Scholarship for the “Workshop on 3D Genome Mapping Technology-ChIA-PET”||The Jackson Laboratory|
|Carroll Feist Predoctoral Research Fellowship||LSU Health Shreveport|
|Outstanding Biochemistry Graduate Student Award (Second Place)||LSU Health Shreveport|
|First Place in Ray A. Barlow Excellence in Cancer Research Award in Barlow Symposium||LSU Health Shreveport|
|Jason A. Cardelli Award for Excellence in Cancer Research||LSU Health Shreveport|
My current research focuses on modeling Lynch syndrome (LS) associated DNA mismatch repair gene variants in human embryonic stem cells using CRISPR-Cas gene editing. We aim to gather variant specific functional data to better inform the clinical diagnosis and stratification of LS patients.
Over the course of the last few years, we have optimized CRISPR based genome engineering to serve as a highly efficient tool to site-specifically incorporate genomic single nucleotide variant change. We aim to improve the throughput of this powerful reverse genetic approach for large scale functional genomics studies and lessen the existing technical constraints. Specifically, we aim to explore novel methodologies to improve homology directed repair outcomes for CRISPR-Cas induced DNA double-strand breaks.