Photo of Abhijit  Rath, Ph.D.

Abhijit Rath, Ph.D.

Assistant Professor, Molecular Oncology
Academic Office Location:
Center for Molecular Oncology
UConn Health
E1032
263 Farmington Avenue
Farmington, CT 06030-3101
Phone: 860-679-8836
Website(s):

Center for Molecular Oncology

Facilitating CRISPR based functional genomics approaches, Modulation of DNA double-strand break repair to enable precision gene editing.

Education
DegreeInstitutionMajor
Ph.D.Louisiana State University Health CenterBiochemistry & Molecular Biology
B.V.M.S.Orissa University of Agriculture & TechnologyVeterinary Science & Animal Husbandry

Post-Graduate Training
TrainingInstitutionSpecialty
FellowshipLouisiana State University Health CenterCarroll Feist Pre-doctoral Research

Awards
Name of Award/HonorAwarding Organization
Full Scholarship for the “Workshop on 3D Genome Mapping Technology-ChIAPET”
Second Place in “Outstanding Biochemistry Student” Award Competition
First Place in Ray A. Barlow Excellence in Cancer Research Award in Barlow Symposium

My current research focuses on modeling Lynch syndrome (LS) associated DNA mismatch repair gene variants in human embryonic stem cells using CRISPR-Cas gene editing. We aim to gather variant specific functional data to better inform the clinical diagnosis and stratification of LS patients. Over the course of the last few years, we have optimized CRISPR based genome engineering to serve as a highly efficient tool to site-specifically incorporate genomic single nucleotide variant change. We aim to improve the throughput of this powerful reverse genetic approach for large scale functional genomics studies and lessen the existing technical constraints. Specifically, we aim to explore novel methodologies to improve homology directed repair outcomes for CRISPR-Cas induced DNA double-strand breaks.

Journal Articles