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Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells.
Wright, Skylar S; Kumari, Puja; Fraile-Ágreda, Víctor; Wang, Chengliang; Shivcharan, Sonia; Kappelhoff, Shirin; Margheritis, Eleonora G; Matz, Alyssa; Vasudevan, Swathy O; Rubio, Ignacio; Bauer, Michael; Zhou, Beiyan; Vanaja, Sivapriya Kailasan; Cosentino, Katia; Ruan, Jianbin; Rathinam, Vijay A Cell 2024 Dec;
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UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling.
Harrison, Andrew G; Yang, Duomeng; Cahoon, Jason G; Geng, Tingting; Cao, Ziming; Karginov, Timofey A; Hu, Youjia; Li, Xin; Chiari, Conner C; Qyang, Yibing; Vella, Anthony T; Fan, Zhichao; Vanaja, Sivapriya Kailasan; Rathinam, Vijay A; Witczak, Carol A; Bogan, Jonathan S; Wang, Penghua Nature immunology 2024 Nov;
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A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis.
Li, Rong; Colombo, Michela; Wang, Guanlin; Rodriguez-Romera, Antonio; Benlabiod, Camelia; Jooss, Natalie J; O'Sullivan, Jennifer; Brierley, Charlotte K; Clark, Sally-Ann; Pérez Sáez, Juan M; Fernández, Pedro Aragón; Schoof, Erwin M; Porse, Bo; Meng, Yiran; Khan, Abdullah O; Wen, Sean; Dong, Pengwei; Zhou, Wenjiang; Sousos, Nikolaos; Murphy, Lauren; Clarke, Matthew; Olijnik, Aude-Anais; Wong, Zoë C; Karali, Christina Simoglou; Sirinukunwattana, Korsuk; Ryou, Hosuk; Norfo, Ruggiero; Cheng, Qian; Carrelha, Joana; Ren, Zemin; Thongjuea, Supat; Rathinam, Vijay A; Krishnan, Anandi; Royston, Daniel; Rabinovich, Gabriel A; Mead, Adam J; Psaila, Bethan Science translational medicine 2024 Oct;16(768):eadj7552
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Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection.
Rooney, Michael; Duduskar, Shivalee N; Ghait, Mohamed; Reißing, Johanna; Stengel, Sven; Reuken, Philipp A; Quickert, Stefanie; Zipprich, Alexander; Bauer, Michael; Russo, Ashley J; Rathinam, Vijay A; Stallmach, Andreas; Rubio, Ignacio; Bruns, Tony Journal of hepatology 2024 Jun;
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The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation.
Harioudh, Munesh K; Perez, Joseph; So, Lomon; Maheshwari, Mayank; Ebert, Thomas S; Hornung, Veit; Savan, Ram; Rouf Banday, A; Diamond, Michael S; Rathinam, Vijay A; Sarkar, Saumendra N Immunity 2024 Jun;
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A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis.
Wright, Skylar S; Wang, Chengliang; Ta, Atri; Havira, Morena S; Ruan, Jianbin; Rathinam, Vijay A; Vanaja, Sivapriya Kailasan Cell reports 2024 Mar;43(4):114004
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Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis.
Kumari, Puja; Vasudevan, Swathy O; Russo, Ashley J; Wright, Skylar S; Fraile-Ágreda, Víctor; Krajewski, Dylan; Jellison, Evan R; Rubio, Ignacio; Bauer, Michael; Shimoyama, Atsushi; Fukase, Koichi; Zhang, Yuanpeng; Pachter, Joel S; Vanaja, Sivapriya Kailasan; Rathinam, Vijay A Nature cell biology 2023 Dec;25(12):1860-1872
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A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3.
Ta, Atri; Ricci-Azevedo, Rafael; Vasudevan, Swathy O; Wright, Skylar S; Kumari, Puja; Havira, Morena S; Surendran Nair, Meera; Rathinam, Vijay A; Vanaja, Sivapriya Kailasan Nature communications 2023 Apr;14(1):2035
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Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Wang, Chengliang; Shivcharan, Sonia; Tian, Tian; Wright, Skylar; Ma, Danyang; Chang, JengYih; Li, Kunpeng; Song, Kangkang; Xu, Chen; Rathinam, Vijay A; Ruan, Jianbin Nature 2023 Apr;616(7957):590-597
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CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis.
Yeung, Stephen T; Ovando, Luis J; Russo, Ashley J; Rathinam, Vijay A; Khanna, Kamal M Cell reports 2023 Mar;42(3):112171
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Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis.
Ramadan, Abdulraouf; Cao, Zhiyi; Hassan, Mujtaba; Zetterberg, Fredrik; Nilsson, Ulf J; Gadjeva, Mihaela; Rathinam, Vijay; Panjwani, Noorjahan Journal of immunology (Baltimore, Md. : 1950) 2023 Feb;210(4):398-407
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The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis.
Ramadan, Abdulraouf; Cao, Zhiyi; Gadjeva, Mihaela; Zaidi, Tanweer S; Rathinam, Vijay A; Panjwani, Noorjahan Investigative ophthalmology & visual science 2023 Feb;64(2):11
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A TLR4-independent critical role for CD14 in intracellular LPS sensing.
Vasudevan, Swathy O; Russo, Ashley J; Kumari, Puja; Vanaja, Sivapriya Kailasan; Rathinam, Vijay A Cell reports 2022 May;39(5):110755
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Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice.
Fan, Zhichao; Pitmon, Elise; Wen, Lai; Miller, Jacqueline; Ehinger, Erik; Herro, Rana; Liu, Wei; Chen, Ju; Mikulski, Zbigniew; Conrad, Douglas J; Marki, Alex; Orecchioni, Marco; Kumari, Puja; Zhu, Yanfang Peipei; Marcovecchio, Paola M; Hedrick, Catherine C; Hodges, Craig A; Rathinam, Vijay A; Wang, Kepeng; Ley, Klaus Journal of immunology (Baltimore, Md. : 1950) 2022 Feb;208(3):745-752
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Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense.
Kumari, Puja; Russo, Ashley J; Wright, Skylar S; Muthupalani, Sureshkumar; Rathinam, Vijay A Cell reports 2021 Apr;35(3):109012
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Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin.
Russo, Ashley J; Vasudevan, Swathy O; Méndez-Huergo, Santiago P; Kumari, Puja; Menoret, Antoine; Duduskar, Shivalee; Wang, Chengliang; Pérez Sáez, Juan M; Fettis, Margaret M; Li, Chuan; Liu, Renjie; Wanchoo, Arun; Chandiran, Karthik; Ruan, Jianbin; Vanaja, Sivapriya Kailasan; Bauer, Michael; Sponholz, Christoph; Hudalla, Gregory A; Vella, Anthony T; Zhou, Beiyan; Deshmukh, Sachin D; Rabinovich, Gabriel A; Rathinam, Vijay A Nature immunology 2021 Feb;22(2):154-165
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Shiga toxin suppresses noncanonical inflammasome responses to cytosolic LPS
Morena S. Havira, Atri Ta, Puja Kumari, Chengliang Wang, Ashley J. Russo, Jianbin Ruan, Vijay A. Rathinam and Sivapriya Kailasan Vanaja* Science Immunology 2020 Nov;5(53)eabc0217
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AIM2 in health and disease: Inflammasome and beyond.
Kumari, Puja; Russo, Ashley J; Shivcharan, Sonia; Rathinam, Vijay A Immunological reviews 2020 Jul;
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Long Noncoding RNAs in Host-Pathogen Interactions.
Agliano, Federica; Rathinam, Vijay A; Medvedev, Andrei E; Vanaja, Sivapriya Kailasan; Vella, Anthony T Trends in immunology 2019 Jun;40(6):492-510
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Innate immunity to intracellular LPS.
Rathinam, Vijay A K; Zhao, Yue; Shao, Feng Nature immunology 2019 May;20(5):527-533
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Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.
Ghosh, Arundhati; Shao, Lulu; Sampath, Padmavathi; Zhao, Baoyu; Patel, Nidhi V; Zhu, Jianzhong; Behl, Bharat; Parise, Robert A; Beumer, Jan H; O'Sullivan, Roderick J; DeLuca, Neal A; Thorne, Stephen H; Rathinam, Vijay A K; Li, Pingwei; Sarkar, Saumendra N Immunity 2019 Jan;50(1):51-63.e5
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Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
Agliano, Federica; Fitzgerald, Katherine A; Vella, Anthony T; Rathinam, Vijay A; Medvedev, Andrei E Frontiers in cellular and infection microbiology 2019 Jan;9481
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Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.
Banerjee, Ishita; Behl, Bharat; Mendonca, Morena; Shrivastava, Gaurav; Russo, Ashley J; Menoret, Antoine; Ghosh, Arundhati; Vella, Anthony T; Vanaja, Sivapriya Kailasan; Sarkar, Saumendra N; Fitzgerald, Katherine A; Rathinam, Vijay A K Immunity 2018 Aug;49413-426.e5
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Lipid Peroxidation Adds Fuel to Pyr(optosis).
Russo, Ashley J; Rathinam, Vijay A K Cell host & microbe 2018 Jul;24(1):8-9
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T cell-directed IL-17 production by lung granular γδ T cells is coordinated by a novel IL-2 and IL-1β circuit.
Ménoret, Antoine; Buturla, James A; Xu, Maria M; Svedova, Julia; Kumar, Sanjeev; Rathinam, Vijay A K; Vella, Anthony T Mucosal immunology 2018 Jun;111398-1407
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(IR)Factor for NAIP Expression.
Vanaja, Sivapriya Kailasan; Rathinam, Vijay A K Cell 2018 May;173(4):817-819
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Inflammasome Complexes: Emerging Mechanisms and Effector Functions.
Rathinam, Vijay A K; Fitzgerald, Katherine A Cell 2016 May;165(4):792-800
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Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation.
Vanaja, Sivapriya Kailasan; Russo, Ashley J; Behl, Bharat; Banerjee, Ishita; Yankova, Maya; Deshmukh, Sachin D; Rathinam, Vijay A K Cell 2016 May;1651106-1119
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GBPs take AIM at Francisella.
Fitzgerald, Katherine A; Rathinam, Vijay A K Nature immunology 2015 Apr;16(5):443-4
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Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Kalantari, Parisa; DeOliveira, Rosane B; Chan, Jennie; Corbett, Yolanda; Rathinam, Vijay; Stutz, Andrea; Latz, Eicke; Gazzinelli, Ricardo T; Golenbock, Douglas T; Fitzgerald, Katherine A Cell reports 2014 Jan;6(1):196-210
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Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system.
Shah, Swati; Bohsali, Amro; Ahlbrand, Sarah E; Srinivasan, Lalitha; Rathinam, Vijay A K; Vogel, Stefanie N; Fitzgerald, Katherine A; Sutterwala, Fayyaz S; Briken, Volker Journal of immunology (Baltimore, Md. : 1950) 2013 Oct;191(7):3514-8
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Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Bossaller, Lukas; Rathinam, Vijay A K; Bonegio, Ramon; Chiang, Ping-I; Busto, Patricia; Wespiser, Adam R; Caffrey, Daniel R; Li, Quan-Zhen; Mohan, Chandra; Fitzgerald, Katherine A; Latz, Eicke; Marshak-Rothstein, Ann Journal of immunology (Baltimore, Md. : 1950) 2013 Sep;191(5):2104-14
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Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Sokolovska, Anna; Becker, Christine E; Ip, W K Eddie; Rathinam, Vijay A K; Brudner, Matthew; Paquette, Nicholas; Tanne, Antoine; Vanaja, Sivapriya K; Moore, Kathryn J; Fitzgerald, Katherine A; Lacy-Hulbert, Adam; Stuart, Lynda M Nature immunology 2013 Jun;14(6):543-53
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Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
Conlon, Joseph; Burdette, Dara L; Sharma, Shruti; Bhat, Numana; Thompson, Mikayla; Jiang, Zhaozhao; Rathinam, Vijay A K; Monks, Brian; Jin, Tengchuan; Xiao, T Sam; Vogel, Stefanie N; Vance, Russell E; Fitzgerald, Katherine A Journal of immunology (Baltimore, Md. : 1950) 2013 May;190(10):5216-25
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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Wang, Donghai; Höing, Susanne; Patterson, Heide Christine; Ahmad, Umtul M; Rathinam, Vijay A K; Rajewsky, Klaus; Fitzgerald, Katherine A; Golenbock, Douglas T The Journal of biological chemistry 2013 Feb;288(7):4594-601
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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β.
Mishra, Bibhuti B; Rathinam, Vijay A K; Martens, Gregory W; Martinot, Amanda J; Kornfeld, Hardy; Fitzgerald, Katherine A; Sassetti, Christopher M Nature immunology 2013 Jan;14(1):52-60
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Outcome of infection of C57BL/6 IL-10(-/-) mice with Campylobacter jejuni strains is correlated with genome content of open reading frames up- and down-regulated in vivo.
Bell, J A; Jerome, J P; Plovanich-Jones, A E; Smith, E J; Gettings, J R; Kim, H Y; Landgraf, J R; Lefébure, T; Kopper, J J; Rathinam, V A; St Charles, J L; Buffa, B A; Brooks, A P; Poe, S A; Eaton, K A; Stanhope, M J; Mansfield, L S Microbial pathogenesis 2013 Jan;541-19
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Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Bossaller, Lukas; Chiang, Ping-I; Schmidt-Lauber, Christian; Ganesan, Sandhya; Kaiser, William J; Rathinam, Vijay A K; Mocarski, Edward S; Subramanian, Deepa; Green, Douglas R; Silverman, Neal; Fitzgerald, Katherine A; Marshak-Rothstein, Ann; Latz, Eicke Journal of immunology (Baltimore, Md. : 1950) 2012 Dec;189(12):5508-12
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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Rathinam, Vijay A K; Vanaja, Sivapriya Kailasan; Waggoner, Lisa; Sokolovska, Anna; Becker, Christine; Stuart, Lynda M; Leong, John M; Fitzgerald, Katherine A Cell 2012 Aug;150(3):606-19
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The NLRP12 inflammasome recognizes Yersinia pestis.
Vladimer, Gregory I; Weng, Dan; Paquette, Sara W Montminy; Vanaja, Sivapriya Kailasan; Rathinam, Vijay A K; Aune, Marie Hjelmseth; Conlon, Joseph E; Burbage, Joseph J; Proulx, Megan K; Liu, Qin; Reed, George; Mecsas, Joan C; Iwakura, Yoichiro; Bertin, John; Goguen, Jon D; Fitzgerald, Katherine A; Lien, Egil Immunity 2012 Jul;37(1):96-107
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Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Jin, Tengchuan; Perry, Andrew; Jiang, Jiansheng; Smith, Patrick; Curry, James A; Unterholzner, Leonie; Jiang, Zhaozhao; Horvath, Gabor; Rathinam, Vijay A; Johnstone, Ricky W; Hornung, Veit; Latz, Eicke; Bowie, Andrew G; Fitzgerald, Katherine A; Xiao, T Sam Immunity 2012 Apr;36(4):561-71
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Defective pro-IL-1β responses in macrophages from aged mice.
Ramirez, Alejandro; Rathinam, Vijay; Fitzgerald, Katherine A; Golenbock, Douglas T; Mathew, Anuja Immunity & ageing : I & A 2012 Jan;9(1):27
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Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.
Panchanathan, Ravichandran; Shen, Hui; Duan, Xin; Rathinam, Vijay A K; Erickson, Loren D; Fitzgerald, Katherine A; Choubey, Divaker Journal of immunology (Baltimore, Md. : 1950) 2011 Jun;186(12):6762-70
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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Nakahira, Kiichi; Haspel, Jeffrey Adam; Rathinam, Vijay A K; Lee, Seon-Jin; Dolinay, Tamas; Lam, Hilaire C; Englert, Joshua A; Rabinovitch, Marlene; Cernadas, Manuela; Kim, Hong Pyo; Fitzgerald, Katherine A; Ryter, Stefan W; Choi, Augustine M K Nature immunology 2011 Mar;12(3):222-30
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Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
Panchanathan, Ravichandran; Duan, Xin; Shen, Hui; Rathinam, Vijay A K; Erickson, Loren D; Fitzgerald, Katherine A; Choubey, Divaker Journal of immunology (Baltimore, Md. : 1950) 2010 Dec;185(12):7385-93
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Genetic diversity in Campylobacter jejuni is associated with differential colonization of broiler chickens and C57BL/6J IL10-deficient mice.
Wilson, David L; Rathinam, Vijay A K; Qi, Weihong; Wick, Lukas M; Landgraf, Jeff; Bell, Julia A; Plovanich-Jones, Anne; Parrish, Jodi; Finley, Russell L; Mansfield, Linda S; Linz, John E Microbiology (Reading, England) 2010 Jul;156(Pt 7):2046-57
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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Rathinam, Vijay A K; Jiang, Zhaozhao; Waggoner, Stephen N; Sharma, Shruti; Cole, Leah E; Waggoner, Lisa; Vanaja, Sivapriya Kailasan; Monks, Brian G; Ganesan, Sandhya; Latz, Eicke; Hornung, Veit; Vogel, Stefanie N; Szomolanyi-Tsuda, Eva; Fitzgerald, Katherine A Nature immunology 2010 May;11(5):395-402
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Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes.
Rathinam, Vijay A K; Appledorn, Daniel M; Hoag, Kathleen A; Amalfitano, Andrea; Mansfield, Linda S Infection and immunity 2009 Jun;77(6):2499-507
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Multiple factors interact to produce responses resembling spectrum of human disease in Campylobacter jejuni infected C57BL/6 IL-10-/- mice.
Bell, Julia A; St Charles, Jessica L; Murphy, Alice J; Rathinam, Vijay A K; Plovanich-Jones, Anne E; Stanley, Erin L; Wolf, John E; Gettings, Jenna R; Whittam, Thomas S; Mansfield, Linda S BMC microbiology 2009 Jan;957
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Dendritic cells from C57BL/6 mice undergo activation and induce Th1-effector cell responses against Campylobacter jejuni.
Rathinam, Vijay A K; Hoag, Kathleen A; Mansfield, Linda S Microbes and infection / Institut Pasteur 2008 Oct;10(12-13):1316-24
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Genetic background of IL-10(-/-) mice alters host-pathogen interactions with Campylobacter jejuni and influences disease phenotype.
Mansfield, L S; Patterson, J S; Fierro, B R; Murphy, A J; Rathinam, V A; Kopper, J J; Barbu, N I; Onifade, T J; Bell, J A Microbial pathogenesis 2008 Oct;45(4):241-57
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C57BL/6 and congenic interleukin-10-deficient mice can serve as models of Campylobacter jejuni colonization and enteritis.
Mansfield, L S; Bell, J A; Wilson, D L; Murphy, A J; Elsheikha, H M; Rathinam, V A K; Fierro, B R; Linz, J E; Young, V B Infection and immunity 2007 Mar;75(3):1099-115