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CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery.
Nguyen, Justin N; Mohan, Eric C; Pandya, Gargee; Ali, Uzma; Tan, Chunfeng; Kofler, Julia K; Shapiro, Linda; Marrelli, Sean P; Chauhan, Anjali Journal of neuroinflammation 2023 Oct;20(1):232
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Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation.
Menon, Nikhil G; Goyal, Ruchi; Lema, Carolina; Woods, Paige S; Tanguay, Adam P; Morin, Alyssa A; Das, Nabangshu; Jay, Gregory D; Krawetz, Roman J; Dufour, Antoine; Shapiro, Linda H; Redfern, Rachel L; Ghosh, Mallika; Schmidt, Tannin A Experimental eye research 2021 Jul;208108628
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CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.
Ghosh, Mallika; Kelava, Tomislav; Madunic, Ivana Vrhovac; Kalajzic, Ivo; Shapiro, Linda H Scientific reports 2021 May;11(1):10736
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A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction - A pilot study.
Devarakonda, Charan Kumar V; Shearier, Emily R; Hu, Chaoran; Grady, James; Balsbaugh, Jeremy L; Makari, John H; Ferrer, Fernando A; Shapiro, Linda H Journal of pediatric urology 2020 Aug;16(4):466.e1-466.e9
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CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis.
Ghosh, M, Kalajzic I, Aguila HL and Shapiro LH BioRxiv 2020 Jun;
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CD13 Regulation of Membrane Recycling: Implications for Cancer Dissemination.
Mallika Ghosh and Linda H. Shapiro Mol. Cell. Oncol. 2019 Aug;
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CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions.
Devarakonda, Charan V; Pereira, Flavia E; Smith, Jonathan D; Shapiro, Linda H; Ghosh, Mallika Atherosclerosis 2019 Jun;28770-80
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CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration.
Ghosh, Mallika; Lo, Robin; Ivic, Ivan; Aguilera, Brian; Qendro, Veneta; Devarakonda, Charan; Shapiro, Linda H Science signaling 2019 Apr;12(579):
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The innate immune response to ischemic injury: a multiscale modeling perspective.
Dimitrova, Elena; Caromile, Leslie A; Laubenbacher, Reinhard; Shapiro, Linda H BMC systems biology 2018 Apr;12(1):50
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Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction.
Ghosh, Mallika; Thangada, Shobha; Dasgupta, Oisharya; Khanna, Kamal M; Yamase, Harold T; Kashgarian, Michael; Hla, Timothy; Shapiro, Linda H; Ferrer, Fernando A PloS one 2018 Jan;13(3):e0194053
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PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer.
Caromile, Leslie Ann; Dortche, Kristina; Rahman, M Mamunur; Grant, Christina L; Stoddard, Christopher; Ferrer, Fernando A; Shapiro, Linda H Science signaling 2017 Mar;10(470):
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Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide.
Conway, Rebecca E; Rojas, Camilo; Alt, Jesse; Nováková, Zora; Richardson, Spencer M; Rodrick, Tori C; Fuentes, Julio L; Richardson, Noah H; Attalla, Jonathan; Stewart, Samantha; Fahmy, Beshoy; Barinka, Cyril; Ghosh, Mallika; Shapiro, Linda H; Slusher, Barbara S Angiogenesis 2016 Jul;19487-500
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Proximal tubule proteins are significantly elevated in bladder urine of patients with ureteropelvic junction obstruction and may represent novel biomarkers: A pilot study.
Gerber, Claire; Harel, Miriam; Lynch, Miranda L; Herbst, Katherine W; Ferrer, Fernando A; Shapiro, Linda H Journal of pediatric urology 2016 Apr;12(2):120.e1-7
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Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma.
Li, Mei-Hong; Swenson, Rolf; Harel, Miriam; Jana, Sampa; Stolarzewicz, Erik; Hla, Timothy; Shapiro, Linda H; Ferrer, Fernando The Journal of pharmacology and experimental therapeutics 2015 Jun;354(3):261-8
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CD13 restricts TLR4 endocytic signal transduction in inflammation.
Ghosh, Mallika; Subramani, Jaganathan; Rahman, M Mamunur; Shapiro, Linda H Journal of immunology (Baltimore, Md. : 1950) 2015 Mar;194(9):4466-76
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The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease.
Kim, Jiyeon; Shapiro, Linda; Flynn, Aidan Pharmacology & therapeutics 2015 Feb;1518-15
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Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction.
Thangada, Shobha; Shapiro, Linda H; Silva, Cynthia; Yamase, Harold; Hla, Timothy; Ferrer, Fernando A The Journal of urology 2014 Mar;191(5 Suppl):1508-16
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Molecular mechanisms regulating CD13-mediated adhesion.
Ghosh, Mallika; Gerber, Claire; Rahman, M Mamunur; Vernier, Kaitlyn M; Pereira, Flavia E; Subramani, Jaganathan; Caromile, Leslie A; Shapiro, Linda H Immunology 2014 Mar;142(4):636-47
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CD13 promotes mesenchymal stem cell-mediated regeneration of ischemic muscle.
Rahman, M Mamunur; Subramani, Jaganathan; Ghosh, Mallika; Denninger, Jiyeon K; Takeda, Kotaro; Fong, Guo-Hua; Carlson, Morgan E; Shapiro, Linda H Frontiers in physiology 2014 Jan;4402
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CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury.
Rahman, M Mamunur; Ghosh, Mallika; Subramani, Jaganathan; Fong, Guo-Hua; Carlson, Morgan E; Shapiro, Linda H Stem cells (Dayton, Ohio) 2013 Dec;32(6):1564-77
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CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice.
Pereira, Flavia E; Cronin, Chunxia; Ghosh, Mallika; Zhou, Si-Yuan; Agosto, Mariela; Subramani, Jaganathan; Wang, Ruibo; Shen, Jian-Bing; Schacke, Wolfgang; Liang, Brannen; Yang, Tie Hong; McAulliffe, Beata; Liang, Bruce T; Shapiro, Linda H Cardiovascular research 2013 Oct;100(1):74-83
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Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking.
Subramani, Jaganathan; Ghosh, Mallika; Rahman, M Mamunur; Caromile, Leslie A; Gerber, Claire; Rezaul, Karim; Han, David K; Shapiro, Linda H Journal of immunology (Baltimore, Md. : 1950) 2013 Aug;191(7):3905-12
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Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2.
Conway, Rebecca E; Joiner, Kyle; Patterson, Alex; Bourgeois, David; Rampp, Robert; Hannah, Benjamin C; McReynolds, Samantha; Elder, John M; Gilfilen, Hannah; Shapiro, Linda H Angiogenesis 2013 Jun;16(4):847-60
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Prostate specific membrane antigen (PSMA) regulates angiogenesis independently of VEGF during ocular neovascularization.
Grant, Christina L; Caromile, Leslie A; Ho, Vivienne; Durrani, Khayyam; Rahman, M Mamunur; Claffey, Kevin P; Fong, Guo-Hua; Shapiro, Linda H PloS one 2012 Jul;7(7):e41285
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CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake.
Ghosh, Mallika; McAuliffe, Beata; Subramani, Jaganathan; Basu, Sreyashi; Shapiro, Linda H Journal of immunology (Baltimore, Md. : 1950) 2012 Jun;188(11):5489-99
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CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse.
Winnicka, Beata; O'Conor, Catherine; Schacke, Wolfgang; Vernier, Kaitlyn; Grant, Christina L; Fenteany, Fiona Hall; Pereira, Flavia E; Liang, Brannen; Kaur, Anupinder; Zhao, Ran; Montrose, David C; Rosenberg, Daniel W; Aguila, Hector L; Shapiro, Linda H Journal of leukocyte biology 2010 Aug;88(2):347-59
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Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Group's Study, ASCT0031
Cuvelier G.D.E., Kariminia A., Fujii H., Aslanian S., Wall D., Goldman F., Grupp S.A., Dunn S.E., Krailo M., Shapiro L.H., Gilman A., Schultz K.R. Bone Marrow Transplantation 2010 Jan;
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CD13 is a novel mediator of monocytic/endothelial cell adhesion.
Mina-Osorio, Paola; Winnicka, Beata; O'Conor, Catherine; Grant, Christina L; Vogel, Lotte K; Rodriguez-Pinto, Daniel; Holmes, Kathryn V; Ortega, Enrique; Shapiro, Linda H Journal of leukocyte biology 2008 Aug;84(2):448-59
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CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element.
Mahoney, Kathleen M M; Petrovic, Nenad; Schacke, Wolfgang; Shapiro, Linda H Gene 2007 Nov;403(1-2):178-87
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CD13/APN regulates endothelial invasion and filopodia formation.
Petrovic, Nenad; Schacke, Wolfgang; Gahagan, J Reed; O'Conor, Catherine A; Winnicka, Beata; Conway, Rebecca E; Mina-Osorio, Paola; Shapiro, Linda H Blood 2007 Jul;110(1):142-50
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Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction.
Conway, Rebecca E; Petrovic, Nenad; Li, Zhong; Heston, Warren; Wu, Dianqing; Shapiro, Linda H Molecular and cellular biology 2006 Jul;26(14):5310-24
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CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells.
Fontijn, D; Duyndam, M C A; van Berkel, M P A; Yuana, Y; Shapiro, L H; Pinedo, H M; Broxterman, H J; Boven, E British journal of cancer 2006 Jun;94(11):1627-36
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CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells.
Mina-Osorio, Paola; Shapiro, Linda H; Ortega, Enrique Journal of leukocyte biology 2006 Apr;79(4):719-30
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Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo.
Wentworth, David E; Tresnan, D B; Turner, B C; Lerman, I R; Bullis, B; Hemmila, E M; Levis, R; Shapiro, L H; Holmes, Kathryn V Virology 2005 May;335(2):185-97
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CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells.
Petrovic, Nenad; Bhagwat, Shripad V; Ratzan, William J; Ostrowski, Michael C; Shapiro, Linda H The Journal of biological chemistry 2003 Dec;278(49):49358-68
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The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis.
Bhagwat, Shripad V; Petrovic, Nenad; Okamoto, Yasuhiro; Shapiro, Linda H Blood 2003 Mar;101(5):1818-26
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Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.
Sampath, J; Sun, D; Kidd, V J; Grenet, J; Gandhi, A; Shapiro, L H; Wang, Q; Zambetti, G P; Schuetz, J D The Journal of biological chemistry 2001 Oct;276(42):39359-67
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CD13/APN is activated by angiogenic signals and is essential for capillary tube formation.
Bhagwat, S V; Lahdenranta, J; Giordano, R; Arap, W; Pasqualini, R; Shapiro, L H Blood 2001 Feb;97(3):652-9
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Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.
Pasqualini, R; Koivunen, E; Kain, R; Lahdenranta, J; Sakamoto, M; Stryhn, A; Ashmun, R A; Shapiro, L H; Arap, W; Ruoslahti, E Cancer research 2000 Feb;60(3):722-7
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c-Maf induces monocytic differentiation and apoptosis in bipotent myeloid progenitors.
Hegde, S P; Zhao, J; Ashmun, R A; Shapiro, L H Blood 1999 Sep;94(5):1578-89
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Discriminating between constitutive and inducible activators: the role of secondary structure
Parker, D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK Mol Cell Biol 1999 Jan;19(8):5601-5607
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Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins.
Inoue, K; Sherr, C J; Shapiro, L H The Journal of biological chemistry 1998 Oct;273(44):29188-94
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c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.
Hedge, S P; Kumar, A; Kurschner, C; Shapiro, L H Molecular and cellular biology 1998 May;18(5):2729-37
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A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions.
Yang, C; Shapiro, L H; Rivera, M; Kumar, A; Brindle, P K Molecular and cellular biology 1998 Apr;18(4):2218-29
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bca: an activation-related B-cell gene.
Gangi-Peterson, L; Peterson, S N; Shapiro, L H; Golding, A; Caricchio, R; Cohen, D I; Margulies, D H; Cohen, P L Molecular immunology 1998 Jan;35(1):55-63
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Redundant functions of B-Myb and c-Myb in differentiating myeloid cells.
Golay, J; Broccoli, V; Borleri, G M; Erba, E; Faretta, M; Basilico, L; Ying, G G; Piccinini, G; Shapiro, L H; Lovric, J; Nawrath, M; Mölling, K; Rambaldi, A; Introna, M Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997 Dec;8(12):1305-16
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Human aminopeptidase N is encoded by 20 exons.
Lerche, C; Vogel, L K; Shapiro, L H; Norén, O; Sjöström, H Mammalian genome : official journal of the International Mammalian Genome Society 1996 Sep;7(9):712-3
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Stromal cell-mediated transcriptional regulation of the CD13/aminopeptidase N gene in leukemic cells.
Saito, M; Kumagai, M; Okazaki, T; Nakazawa, S; Shapiro, L H; Look, A T; Campana, D Leukemia 1995 Sep;9(9):1508-16
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E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.
Yoshihara, T; Inaba, T; Shapiro, L H; Kato, J Y; Look, A T Molecular and cellular biology 1995 Jun;15(6):3247-55
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Myb and Ets proteins cooperate to transactivate an early myeloid gene.
Shapiro, L H The Journal of biological chemistry 1995 Apr;270(15):8763-71
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B-cell-specific demethylation of BTK, the defective gene in X-linked agammaglobulinemia.
Parolini, O; Rohrer, J; Shapiro, L H; Conley, M E Immunogenetics 1995 Jan;42(2):129-35
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Transcriptional regulation in myeloid cell differentiation.
Shapiro, L H; Look, A T Current opinion in hematology 1995 Jan;2(1):3-11
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Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.
Shapiro, D N; Jones, B G; Shapiro, L H; Dias, P; Houghton, P J The Journal of clinical investigation 1994 Sep;94(3):1235-42
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DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.
Inaba, T; Shapiro, L H; Funabiki, T; Sinclair, A E; Jones, B G; Ashmun, R A; Look, A T Molecular and cellular biology 1994 May;14(5):3403-13
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[Creation of synthetic serine proteinase inhibitors, an important pharmacological problem].
Markwardt, F Farmakologiia i toksikologiia 1994 Jan;41(5):530-3
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Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
Inaba, T; Roberts, W M; Shapiro, L H; Jolly, K W; Raimondi, S C; Smith, S D; Look, A T Science (New York, N.Y.) 1992 Jul;257(5069):531-4
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Deletion of the zinc-binding motif of CD13/aminopeptidase N molecules results in loss of epitopes that mediate binding of inhibitory antibodies.
Ashmun, R A; Shapiro, L H; Look, A T Blood 1992 Jun;79(12):3344-9
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Human aminopeptidase N is a receptor for human coronavirus 229E.
Yeager, C L; Ashmun, R A; Williams, R K; Cardellichio, C B; Shapiro, L H; Look, A T; Holmes, K V Nature 1992 Jun;357(6377):420-2
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Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia.
Privitera, E; Kamps, M P; Hayashi, Y; Inaba, T; Shapiro, L H; Raimondi, S C; Behm, F; Hendershot, L; Carroll, A J; Baltimore, D Blood 1992 Apr;79(7):1781-8
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Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters.
Roberts, W M; Shapiro, L H; Ashmun, R A; Look, A T Blood 1992 Feb;79(3):586-93
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Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells.
Shapiro, L H; Ashmun, R A; Roberts, W M; Look, A T The Journal of biological chemistry 1991 Jun;266(18):11999-2007
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Carbonic anhydrase II is induced in HL-60 cells by 1,25-dihydroxyvitamin D3: a model for osteoclast gene regulation.
Hillstrom Shapiro, L; Venta, P J; Yu, Y S; Tashian, R E FEBS letters 1989 Jun;249(2):307-10
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Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N
Look AT, Ashmun RA, Shapiro LH, Peiper SC J Clin Invest. 1989 Jan;83(4):1299-1307
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Molecular analysis of G+C-rich upstream sequences regulating transcription of the human carbonic anhydrase II gene.
Shapiro, L H; Venta, P J; Tashian, R E Molecular and cellular biology 1987 Dec;7(12):4589-93
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A unique immune response control locus mapping with the H-2D class I region.
Niederhuber, J E; Dugan, E S; Shaprio, L H; Ernst, L Surgery 1986 Aug;100(2):424-9
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Monoclonal antibody characterization of a unique immune response control locus between H-2S and D.
Shapiro, L H; Dugan, E S; Neiderhuber, J E The Journal of experimental medicine 1985 Jan;162(5):1477-93
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IR gene regulation of the response to trinitrophenyl-polysaccharides. Two independent genes are required for antibody production.
Hillstrom, L M; Niederhuber, J E The Journal of experimental medicine 1983 Jun;157(6):2002-16
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A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction – A pilot study
Charan Kumar V. Devarakonda Ph.D., Emily R. Shearier Ph.D., Chaoran Hu, James Grady Dr.P.H., Jeremy L. Balsbaugh Ph.D., John H. Makari M.D. Fernando A. Ferrer M.D., FAAP, FACS, Linda H. Shapiro Ph.D. J. Pediatric Urology