Faculty Directory › UConn Health

Mahesh Thirunavukkarasu, PhD

Assistant Professor of Surgery


Academic Office Location: Department of Surgery UConn Health 263 Farmington Avenue Farmington, CT 06030
Phone:	860-679-8089 860-679-2825
Fax:	860-679-2825

Education & Training
Committees & Organizations
Publications
Presentations

Education

Degree	Institution	Major
BSc	University of Madras	Biochemistry
MSc	Annamalai University, Annamalai Nagar	Biochemistry
MPhil	Annamalai University, Annamalai Nagar	Biochemistry
PhD	Annamalai University, Annamalai Nagar,	Biochemistry

Degree

Institution

Major

BSc

University of Madras

Biochemistry

MSc

Annamalai University, Annamalai Nagar

Biochemistry

MPhil

Annamalai University, Annamalai Nagar

Biochemistry

PhD

Annamalai University, Annamalai Nagar,

Biochemistry

Post-Graduate Training

Training	Institution	Specialty
Postdoctoral	University of Connecticut Health Center	University Postdoctoral Fellow

Training

Institution

Specialty

Postdoctoral

University of Connecticut Health Center

University Postdoctoral Fellow

Awards

Name of Award/Honor	Awarding Organization
Dr. Reddy’s Laboratories Junior Scientist Award in Molecular Biology	ASIOA
Resident/Fellow Excellence in Research Award: Cardiothoracic surgery	American College of Surgeons
Resident/Fellow Excellence in Research Award: Cardiothoracic Surgery	American College of Surgeons
Resident/Fellow Excellence in Research Award: Vascular Surgery	American College of Surgeons
BCVS Abstract Travel Grant	American Heart Association
Young Investigator Award	International College of Angiology

Name of Award/Honor

Awarding Organization

Dr. Reddy’s Laboratories Junior Scientist Award in Molecular Biology

ASIOA

Resident/Fellow Excellence in Research Award: Cardiothoracic surgery

American College of Surgeons

Resident/Fellow Excellence in Research Award: Cardiothoracic Surgery

American College of Surgeons

Resident/Fellow Excellence in Research Award: Vascular Surgery

American College of Surgeons

BCVS Abstract Travel Grant

American Heart Association

Young Investigator Award

International College of Angiology

Name & Description	Category	Role	Type	Scope	Start Year	End Year
AHA Pre and Post-doctoral Fellowship, Cardiology 2 Fellowship committee, Cardiac Biology Basic Science as the primary science classification	Study Section	Reviewer	External	National	2021	2023
Molecular Biology Reports	Editorial Board	Editorial Board Member	External	International	2014
Guest editor for the special issue “Antioxidants in Longevity and Medicine” in the journal Oxidative Medicine and Longevity	Editorial Board	Guest Editor	External	International	2014	2014
Guest Editor for the special Issue “Antioxidants in Longevity and Medicine” in the journal Oxidative Medicine and Longevity	Editorial Board	Guest Editor	External	International	2013	2013
American Heart Association	Professional/Scientific Organization	Member	External	National

Name & Description

Journal Articles

Biodegradable piezoelectric skin-wound scaffold.
Das, Ritopa; Le, Thinh T; Schiff, Benjamin; Chorsi, Meysam T; Park, Jinyoung; Lam, Priscilla; Kemerley, Andrew; Supran, Ajayan Mannoor; Eshed, Amit; Luu, Ngoc; Menon, Nikhil G; Schmidt, Tannin A; Wang, Hanzhang; Wu, Qian; Thirunavukkarasu, Mahesh; Maulik, Nilanjana; Nguyen, Thanh D Biomaterials 2023 Oct;301122270
Novel approaches to determine the functional role of cardiomyocyte specific E3 ligase, Pellino-1 following myocardial infarction.
Pradeep, Seetur R; Thirunavukkarasu, Mahesh; Accorsi, Diego; Swaminathan, Santosh; Lim, Sue Ting; Cernuda, Bryan; Kemerley, Andrew; Hubbard, Jennifer; Campbell, Jacob; Wilson, Rickesha L; Coca-Soliz, Vladimir; Tapias, Leonidas; Selvaraju, Vaithinathan; Jellison, Evan R; Yee, Siu-Pok; Palesty, J Alexander; Maulik, Nilanjana Biochimica et biophysica acta. Molecular basis of disease 2023 Sep;1870(1):166899
Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model †.
Thirunavukkarasu, Mahesh; Swaminathan, Santosh; Kemerley, Andrew; Pradeep, Seetur R; Lim, Sue Ting; Accorsi, Diego; Wilson, Rickesha; Campbell, Jacob; Saad, Ibnalwalid; Yee, Siu-Pok; Palesty, J Alexander; McFadden, David W; Maulik, Nilanjana Cells 2023 Jun;12(11):
Extracellular Vesicles Derived from Thioredoxin-1–Overexpressed Mice Ameliorates Pathologic Wound Healing and Promotes Angiogenesis in Murine Ischemic Wound Model
Kemerley, Andrew DO*; Accorsi, Diego A MD; Ting-Lim, Sue; Supran, Ajayan M PhD; Lam, Priscilla E MD; Swaminathan, Santosh MBBS; Thirunavukkarasu, Mahesh PhD; Palesty, J Alexander MD, FACS,; Maulik, Nilanjana PhD, FAHA Journal of the American College of Surgeons, 235(5):p S79, November 2022. 2022 Nov;
Driving adult tissue repair via re-engagement of a pathway required for fetal healing.
Ghatak, Subhadip; Khanna, Savita; Roy, Sashwati; Thirunavukkarasu, Mahesh; Pradeep, Seetur R; Wulff, Brian C; El Masry, Mohamed S; Sharma, Anu; Palakurti, Ravichand; Ghosh, Nandini; Xuan, Yi; Wilgus, Traci A; Maulik, Nilanjana; Yoder, Mervin C; Sen, Chandan K Molecular therapy : the journal of the American Society of Gene Therapy 2022 Sep;
Protective Effect of Cardiomyocyte-Specific Prolyl-4-Hydroxylase 2 Inhibition on Ischemic Injury in a Mouse MI Model.
Pradeep, Seetur R; Lim, Sue Ting; Thirunavukkarasu, Mahesh; Joshi, Mandip; Cernuda, Bryan; Palesty, J Alexander; Maulik, Nilanjana Journal of the American College of Surgeons 2022 Aug;235(2):240-254
Gene therapy with Pellino-1 improves perfusion and decreases tissue loss in Flk-1 heterozygous mice but fails in MAPKAP Kinase-2 knockout murine hind limb ischemia model.
Thirunavukkarasu, Mahesh; Pradeep, Seetur R; Ukani, Gopi; Abunnaja, Salim; Youssef, Mark; Accorsi, Diego; Swaminathan, Santosh; Lim, Sue Ting; Parker, Virginia; Campbell, Jacob; Tipu Rishi, Muhammad; Palesty, J Alexander; Maulik, Nilanjana Microvascular research 2022 Jan;141104311
Overexpression of Thioredoxin-1 Ameliorates the Progression of Diabetic Cardiomyopathy by Preservation of Cardiac Function, Increased Survivability and Decreased Fibrosis in Aged Transgenic Mice.
Sue-Ting Lim, Seetur R Pradeep, Mahesh Thirunavukkarasu, Santosh Swaminathan, Diego Accorsi, J Alexander Palesty, and Nilanjana Maulik. Circulation 2021 Nov;144A11457
Heat shock protein A12B gene therapy improves perfusion, promotes neovascularization, and decreases fibrosis in a murine model of hind limb ischemia.
Thirunavukkarasu, Mahesh; Tipu Rishi, Muhammad; Pradeep, Seetur R; Swaminathan, Santosh; Accorsi, Diego; Palesty, John Alexander; Maulik, Nilanjana Surgery 2021 Jun;170(3):969-977
Engineered resveratrol-loaded fibrous scaffolds promotes functional cardiac repair and regeneration through Thioredoxin-1 mediated VEGF pathway.
Campbell, Jacob D; Lakshmanan, Rajesh; Selvaraju, Vaithinathan; Accorsi, Diego; McFadden, David W; Maulik, Nilanjana; Thirunavukkarasu, Mahesh International Journal of Pharmaceutics 2021 Feb;597120236
Thioredoxin-1 Engineered Exosomes: A New Tool to Stimulate Revascularization and Regeneration of Ischemic Tissue by Decreasing Fibrosis, Increasing Blood Perfusion and Vessel Density in a Murine Model of Hind-Limb Ischemia
Accorsi, DA, Ukani, G, Radhakrishna, PS, Campbell, J, Thirunavukkarasu, M, McFadden, DW, Palesty, A, Maulik, N. Journal of the American College of Surgeons 2020 Oct;VOLUME 231(ISSUE 4, SUPPLEMENT 1):S359-S360
Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.
Selvaraju, Vaithinathan; Thirunavukkarasu, Mahesh; Joshi, Mandip; Oriowo, Babatunde; Shaikh, Inam A; Rishi, Muhammad Tipu; Tapias, Leonidas; Coca-Soliz, Vladimir; Saad, Ibnalwalid; Campbell, Jacob; Pradeep, Seetur R; Swaminathan, Santosh; Yee, Siu-Pok; McFadden, David W; Alexander Palesty, J; Maulik, Nilanjana Basic Research in Cardiology 2020 Jun;115(4):45
Implanted Resveratrol-Loaded PCL Scaffold Improves Cardiac Function after Myocardial Infarction in Mice.
Jacob D Campbell, Vaithinathan Selvaraju, David W McFadden, Mahesh Thirunavukkarasu, Nilanjana Maulik. Journal of Americal College of Surgeons 2019 Oct;229(No. 4S2):e215
Injection of Exosomes Isolated from Thioredoxin-1 Overexpressed Mice Leads to Improved Cardiac Function and Decreased Fibrosis after Myocardial Infarction
Jennifer Hubbard, Pradeep Seetur Radhakrishna, Mahesh Thirunavukkarasu, David W., McFadden, J Alexandar Palesty, Nilanjana Maulik. Journal of the American College of Surgeons 2019 Oct;229(4, S1):S46
Evaluation of dermal tissue regeneration using resveratrol loaded fibrous matrix in a preclinical mouse model of full-thickness ischemic wound.
Lakshmanan, Rajesh; Campbell, Jacob; Ukani, Gopi; O'Reilly Beringhs, André; Selvaraju, Vaithinathan; Thirunavukkarasu, Mahesh; Lu, Xiuling; Palesty, J Alexander; Maulik, Nilanjana International journal of pharmaceutics 2019 Jan;558177-186
Disruption of VEGF Mediated Flk-1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino-1.
Thirunavukkarasu, Mahesh; Selvaraju, Vaithinathan; Joshi, Mandip; Coca-Soliz, Vladimir; Tapias, Leonidas; Saad, IbnalWalid; Fournier, Craig; Husain, Aaftab; Campbell, Jacob; Yee, Siu-Pok; Sanchez, Juan A; Palesty, J Alexander; McFadden, David W; Maulik, Nilanjana Journal of the American Heart Association 2018 Sep;7(18):e007601
Thioredoxin-1 augments wound healing and promote angiogenesis in a murine ischemic full-thickness wound model.
Saad, Ibnalwalid; Fournier, Craig T; Wilson, Rickesha L; Lakshmanan, Rajesh; Selvaraju, Vaithinathan; Thirunavukkarasu, Mahesh; Alexander Palesty, J; McFadden, David W; Maulik, Nilanjana Surgery 2018 Aug;164(5):1077-1086
Thioredoxin-1 attenuates sepsis-induced cardiomyopathy after cecal ligation and puncture in mice.
Wilson, Rickesha L; Selvaraju, Vaithinathan; Lakshmanan, Rajesh; Thirunavukkarasu, Mahesh; Campbell, Jacob; McFadden, David W; Maulik, Nilanjana The Journal of surgical research 2017 Dec;22068-78
Overexpression of Thioredoxin1 enhances functional recovery in a mouse model of hind limb ischemia.
Shaikh, Inam A; Rishi, Muhammad Tipu; Youssef, Mark; Selvaraju, Vaithinathan; Thirunavukkarasu, Mahesh; Ukani, Gopi; Lakshmanan, Rajesh; Palesty, J Alexander; Maulik, Nilanjana The Journal of surgical research 2017 Aug;216158-168
Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein A12B to Prevent Ventricular Dysfunction Following Acute Myocardial Infarction in Diabetic Rats.
Selvaraju, Vaithinathan; Suresh, Sumanth C; Thirunavukkarasu, Mahesh; Mannu, Jayakanthan; Foye, Jocelyn L C; Mathur, Premendu P; Palesty, J Alexander; Sanchez, Juan A; McFadden, David W; Maulik, Nilanjana Journal of cardiovascular translational research 2017 Mar;10(2):209-220
Increased Survivability of Ischemic Skin Flap Tissue in Flk-1(+/-) Mice by Pellino-1 Intervention.
Rednam, Chandra K; Wilson, Rickesha L; Selvaraju, Vaithinathan; Rishi, Muhammad T; Thirunavukkarasu, Mahesh; Coca-Soliz, Vladimir; Lakshmanan, Rajesh; Palesty, J Alexander; McFadden, David W; Maulik, Nilanjana Microcirculation 2017 Feb;24(6):e12362
Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium.
Suresh, Sumanth C; Selvaraju, Vaithinathan; Thirunavukkarasu, Mahesh; Goldman, Joshua W; Husain, Aaftab; Alexander Palesty, J; Sanchez, Juan A; McFadden, David W; Maulik, Nilanjana International journal of cardiology 2015 Dec;201517-28
Protective effects of Phyllanthus emblica against myocardial ischemia-reperfusion injury: the role of PI3-kinase/glycogen synthase kinase 3β/β-catenin pathway.
Thirunavukkarasu, Mahesh; Selvaraju, Vaithinathan; Tapias, Leonidas; Sanchez, Juan A; Palesty, J Alexander; Maulik, Nilanjana Journal of physiology and biochemistry 2015 Sep;71623-33
Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis.
Wang, Ying; Cao, Ying; Yamada, Satsuki; Thirunavukkarasu, Mahesh; Nin, Veronica; Joshi, Mandip; Rishi, Muhammed T; Bhattacharya, Santanu; Camacho-Pereira, Juliana; Sharma, Anil K; Shameer, Khader; Kocher, Jean-Pierre A; Sanchez, Juan A; Wang, Enfeng; Hoeppner, Luke H; Dutta, Shamit K; Leof, Edward B; Shah, Vijay; Claffey, Kevin P; Chini, Eduardo N; Simons, Michael; Terzic, Andre; Maulik, Nilanjana; Mukhopadhyay, Debabrata Arteriosclerosis, thrombosis, and vascular biology 2015 Apr;35(6):1401-12
Deletion of prolyl hydroxylase domain proteins (PHD1, PHD3) stabilizes hypoxia inducible factor-1 alpha, promotes neovascularization, and improves perfusion in a murine model of hind-limb ischemia.
Rishi, Muhammad T; Selvaraju, Vaithinathan; Thirunavukkarasu, Mahesh; Shaikh, Inam A; Takeda, Kotaro; Fong, Guo-Hua; Palesty, J Alexander; Sanchez, Juan A; Maulik, Nilanjana Microvascular research 2015 Jan;97181-8
Targeted gene deletion of prolyl hydroxylase domain protein 3 triggers angiogenesis and preserves cardiac function by stabilizing hypoxia inducible factor 1 alpha following myocardial infarction.
Oriowo, Babatunde; Thirunavukkarasu, Mahesh; Selvaraju, Vaithinathan; Adluri, Ram Sudheer; Zhan, Lijun; Takeda, Kotaro; Fong, Guo-Hua; Sanchez, Juan A; Maulik, Nilanjana Current pharmaceutical design 2014 Jan;20(9):1305-10
Cardioprotective efficacy of a novel antioxidant mix VitaePro against ex vivo myocardial ischemia-reperfusion injury.
Adluri, Ram Sudheer; Thirunavukkarasu, Mahesh; Zhan, Lijun; Maulik, Nilanjana; Svennevig, Katja; Bagchi, Manashi; Maulik, Gautam Cell biochemistry and biophysics 2013 Nov;67(2):281-6
Simvastatin treatment inhibits hypoxia inducible factor 1-alpha-(HIF-1alpha)-prolyl-4-hydroxylase 3 (PHD-3) and increases angiogenesis after myocardial infarction in streptozotocin-induced diabetic rat.
Thirunavukkarasu, Mahesh; Selvaraju, Vaithinathan; Dunna, Nageswara Rao; Foye, Jocelyn L C; Joshi, Mandip; Otani, Hajime; Maulik, Nilanjana International journal of cardiology 2013 Apr;168(3):2474-80
Novel role of NADPH oxidase in ischemic myocardium: a study with Nox2 knockout mice.
Thirunavukkarasu, Mahesh; Adluri, Ram Sudheer; Juhasz, Bela; Samuel, Samson Mathews; Zhan, Lijun; Kaur, Anupinder; Maulik, Gautam; Sanchez, Juan A; Hager, Janet; Maulik, Nilanjana Functional & integrative genomics 2012 Aug;12(3):501-14
Glutaredoxin-1 overexpression enhances neovascularization and diminishes ventricular remodeling in chronic myocardial infarction.
Adluri, Ram Sudheer; Thirunavukkarasu, Mahesh; Zhan, Lijun; Dunna, Nageswara Rao; Akita, Yuzo; Selvaraju, Vaithinathan; Otani, Hajime; Sanchez, Juan A; Ho, Ye-Shih; Maulik, Nilanjana PloS one 2012 Jan;7(3):e34790
Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxia-inducible factor-1α transcription factor and its target genes in mice.
Adluri, Ram Sudheer; Thirunavukkarasu, Mahesh; Dunna, Nageswara Rao; Zhan, Lijun; Oriowo, Babatunde; Takeda, Kotaro; Sanchez, Juan A; Otani, Hajime; Maulik, Gautam; Fong, Guo-Hua; Maulik, Nilanjana Antioxidants & redox signaling 2011 Oct;15(7):1789-97
Thioredoxin 1 enhances neovascularization and reduces ventricular remodeling during chronic myocardial infarction: a study using thioredoxin 1 transgenic mice.
Adluri, Ram Sudheer; Thirunavukkarasu, Mahesh; Zhan, Lijun; Akita, Yuzo; Samuel, Samson Mathews; Otani, Hajime; Ho, Ye-Shih; Maulik, Gautam; Maulik, Nilanjana Journal of molecular and cellular cardiology 2011 Jan;50(1):239-47
Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids.
Wetzelberger, Karin; Baba, Shahid P; Thirunavukkarasu, Mahesh; Ho, Ye-Shih; Maulik, Nilanjana; Barski, Oleg A; Conklin, Daniel J; Bhatnagar, Aruni The Journal of biological chemistry 2010 Aug;285(34):26135-48
Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats.
Samuel, Samson Mathews; Thirunavukkarasu, Mahesh; Penumathsa, Suresh Varma; Koneru, Srikanth; Zhan, Lijun; Maulik, Gautam; Sudhakaran, Perumana R; Maulik, Nilanjana Circulation 2010 Mar;121(10):1244-55
Coadministration of adenoviral vascular endothelial growth factor and angiopoietin-1 enhances vascularization and reduces ventricular remodeling in the infarcted myocardium of type 1 diabetic rats.
Samuel, Samson Mathews; Akita, Yuzo; Paul, Debayon; Thirunavukkarasu, Mahesh; Zhan, Lijun; Sudhakaran, Perumana R; Li, Chuanfu; Maulik, Nilanjana Diabetes 2010 Jan;59(1):51-60
Sildenafil augments early protective transcriptional changes after ischemia in mouse myocardium.
Vidavalur, Ramesh; Penumathsa, Suresh Varma; Thirunavukkarasu, Mahesh; Zhan, Lijun; Krueger, Winfried; Maulik, Nilanjana Gene 2009 Feb;430(1-2):30-7
Thioredoxin-1 gene delivery induces heme oxygenase-1 mediated myocardial preservation after chronic infarction in hypertensive rats.
Koneru, Srikanth; Penumathsa, Suresh V; Thirunavukkarasu, Mahesh; Zhan, Lijun; Maulik, Nilanjana American journal of hypertension 2009 Feb;22(2):183-90
Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injury.
Penumathsa, Suresh Varma; Thirunavukkarasu, Mahesh; Samuel, Samson Mathews; Zhan, Lijun; Maulik, Gautam; Bagchi, Manashi; Bagchi, Debasis; Maulik, Nilanjana Biochimica et biophysica acta 2009 Jan;1792(1):39-48
Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity.
Samuel, Samson Mathews; Thirunavukkarasu, Mahesh; Penumathsa, Suresh Varma; Paul, Debayon; Maulik, Nilanjana Journal of agricultural and food chemistry 2008 Oct;56(20):9692-8
White wine induced cardioprotection against ischemia-reperfusion injury is mediated by life extending Akt/FOXO3a/NFkappaB survival pathway.
Thirunavukkarasu, Mahesh; Penumathsa, Suresh Varma; Samuel, Samson Mathews; Akita, Yuzo; Zhan, Lijun; Bertelli, Alberto A E; Maulik, Gautam; Maulik, Nilanjana Journal of agricultural and food chemistry 2008 Aug;56(15):6733-9
Adeno-sh-beta-catenin abolishes ischemic preconditioning-mediated cardioprotection by downregulation of its target genes VEGF, Bcl-2, and survivin in ischemic rat myocardium.
Thirunavukkarasu, Mahesh; Han, Zhihua; Zhan, Lijun; Penumathsa, Suresh Varma; Menon, Venugopal P; Maulik, Nilanjana Antioxidants & redox signaling 2008 Aug;10(8):1475-84
Heterozygous disruption of Flk-1 receptor leads to myocardial ischaemia reperfusion injury in mice: application of affymetrix gene chip analysis.
Thirunavukkarasu, M; Addya, S; Juhasz, B; Pant, R; Zhan, L; Surrey, S; Maulik, G; Menon, V P; Maulik, N Journal of cellular and molecular medicine 2008 Aug;12(4):1284-302
Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium.
Juhasz, Bela; Thirunavukkarasu, Mahesh; Pant, Rima; Zhan, Lijun; Penumathsa, Suresh Varma; Secor, Eric R; Srivastava, Sapna; Raychaudhuri, Utpal; Menon, Venugopal P; Otani, Hajime; Thrall, Roger S; Maulik, Nilanjana American journal of physiology. Heart and circulatory physiology 2008 Mar;294(3):H1365-70
Upregulation of myocardial 11S-activated proteasome in experimental hyperglycemia.
Powell, Saul R; Samuel, Samson Mathews; Wang, Ping; Divald, Andras; Thirunavukkarasu, Mahesh; Koneru, Srikanth; Wang, Xuejun; Maulik, Nilanjana Journal of molecular and cellular cardiology 2008 Mar;44(3):618-21
VEGFR1 (Flt-1+/-) gene knockout leads to the disruption of VEGF-mediated signaling through the nitric oxide/heme oxygenase pathway in ischemic preconditioned myocardium.
Thirunavukkarasu, Mahesh; Juhasz, Bela; Zhan, Lijun; Menon, Venugopal P; Tosaki, Arpad; Otani, Hajime; Maulik, Nilanjana Free radical biology & medicine 2007 May;42(10):1487-95
Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat.
Penumathsa, Suresh Varma; Thirunavukkarasu, Mahesh; Koneru, Srikanth; Juhasz, Bela; Zhan, Lijun; Pant, Rima; Menon, Venugopal P; Otani, Hajime; Maulik, Nilanjana Journal of molecular and cellular cardiology 2007 Mar;42(3):508-16
Secoisolariciresinol diglucoside: relevance to angiogenesis and cardioprotection against ischemia-reperfusion injury.
Penumathsa, Suresh Varma; Koneru, Srikanth; Thirunavukkarasu, Mahesh; Zhan, Lijun; Prasad, Kailash; Maulik, Nilanjana The Journal of pharmacology and experimental therapeutics 2007 Feb;320(2):951-9
Niacin-bound chromium enhances myocardial protection from ischemia-reperfusion injury.
Thirunavukkarasu, Mahesh; Penumathsa, Suresh Varma; Juhasz, Bela; Zhan, Lijun; Cordis, Gerald; Altaf, Elham; Bagchi, Manashi; Bagchi, Debasis; Maulik, Nilanjana American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H820-6
Sildenafil induces angiogenic response in human coronary arteriolar endothelial cells through the expression of thioredoxin, hemeoxygenase and vascular endothelial growth factor.
Vidavalur, Ramesh; Penumathsa, Suresh Varma; Zhan, Lijun; Thirunavukkarasu, Mahesh; Maulik, Nilanjana Vascular pharmacology 2006 Aug;45(2):91-5

Book Chapters

Personalized Nutrition The New Era of Nutrition/ Chapter 2
Diego Accorsi, Pradeep Seetur Radhakrishna, Jennifer Hubbard, Rajesh Lakshmanan, Nilanjana Maulik, and Mahesh Thirunavukkarasu. Personalized Nutrition as Medical Therapy for High-Risk Diseases 2020 Apr;
The effects of resveratrol on Diabetes and obesity, Chapter 33
Sanchez JA, Thirunavukkarasu M and Maulik N. Nutritional and Therapeutic Intervention of Diabetes and Metabolic Syndrome 2011 Jan;413-430

Abstracts

Cardiomyocyte Specific Overexpression of Pellino-1 Reverses Sepsis induced Cardiac Dysfunction in a Murine Model by Reducing Inflammatory Response and Cardiac Cell Death
Santosh Swaminathan, Seetur Radhakrishna Pradeep, Rickesha L. Wilson, Jacob Campbell, Mahesh Thirunavukkarasu, Diego Accorsi, Alexander J Palesty, Nilanjana Maulik. Circulation 2020 Nov;142(Suppl No.3):A14673
Cardiomyocyte Specific Pellino1 Knockout Leads to Increased Oxidative Stress, Reduced Anti-apoptotic Signaling and Cardiac Dysfunction in a Murine Myocardial Infarction Model.
Seetur R. Pradeep, Jacob campbell, Mahesh THIRUNAVUKKARASU, Diego Accorsi, J. Alexander Palesty, Nilanjana Maulik Circulation 2020 Nov;142(Suppl No. 3):A15238
Gene Therapy with Pellino-1 Improves Perfusion and Decreases Tissue Loss in an Flk-1 Heterozygous Murine Hind Limb Ischemia Model But Fails In MAPKAPKinase2 Knockout Mice
Diego Accorsi, Mahesh Thirunavukkarasu, Gopi Ukani, Mark Youssef, Santosh Swaminathan, Alexander Palesty, Nilanjana Maulik. Circulation 2020 Nov;142(Suppl No.3):A15314
Pellino-1 overexpression in cardiomyocyte enhances cardiac function and attenuates ventricular remodeling in murine myocardial infarction model.
Jacob Campbell, Vaithinathan Selvaraju, Mahesh Thirunavukkarasu,Coca-Soliz Vladamir, Leonidias Tapias, Kurapaty Venkatapoorna Chandramohan, Siu-Pok Yee, David W McFadden, J.Alexander Palesty, Maulik N. Journal of the American College of Surgeons 2017 Oct;225S33

Editorials

Antioxidants in Longevity and Medicine 2014.
Parinandi, Narasimham L; Maulik, Nilanjana; Thirunavukkarasu, Mahesh; McFadden, David W Oxidative medicine and cellular longevity 2015 Jan;2015739417
Antioxidants in longevity and medicine.
Maulik, Nilanjana; McFadden, David; Otani, Hajime; Thirunavukkarasu, Mahesh; Parinandi, Narasimham L Oxidative medicine and cellular longevity 2013 Jan;2013820679

Letters

Reply to the letter "thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy is a promising feasible therapeutic approach for myocardial infarction".
Maulik, Nilanjana; Thirunavukkarasu, Mahesh; Selvaraju, Vaithinathan; Suresh, Sumanth C International journal of cardiology 2016 Mar;207277-8

Other

Andrew Kemerley Clinical Congress 2022, American College of Surgeons: Owen H Wangensteen Scientific Forum Excellence in Research Awards, Journal of the American College of Surgeons 2022 Nov;235(5)S5-S16

Reviews

HIF-prolyl hydroxylases and cardiovascular diseases.
Sen Banerjee, Sucharita; Thirunavukkarasu, Mahesh; Tipu Rishi, Muhammad; Sanchez, Juan A; Maulik, Nilanjana; Maulik, Gautam Toxicology mechanisms and methods 2012 Jun;22(5):347-58
Ex vivo and in vivo approaches to study mechanisms of cardioprotection targeting ischemia/reperfusion (i/r) injury: useful techniques for cardiovascular drug discovery.
Vidavalur, Ramesh; Swarnakar, Snehasikta; Thirunavukkarasu, Mahesh; Samuel, Samson Mathews; Maulik, Nilanjana Current drug discovery technologies 2008 Dec;5(4):269-78
Growth factors and cell therapy in myocardial regeneration.
Maulik, Nilanjana; Thirunavukkarasu, Mahesh Journal of molecular and cellular cardiology 2008 Feb;44(2):219-27

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
Isolation and Characterization of Thioredoxin-1 Engineered Exosomes and its Role in Cardiac Function Following Myocardial Infarction	Talk	NESS, 26th Annual Surgical Resident and Fellow Presentation Day	2019	Waltham, MA
Injection of Exosomes Isolated from Thioredoxin-1 Overexpressed Mice Leads to Improved Cardiac Function and Decreased Fibrosis after Myocardial Infarction.	Talk	Clinical Congress, Americal college of Surgeons	2019	San Francisco
Resveratrol-Loaded PCL Scaffold Improves Cardiac Function after Myocardial Infarction in Mice	Poster	Clinical Congress, Americal college of Surgeons	2019	San Francisco
Bioengineered Nanofiber Scaffold Induces Healthy Wound Healing in a Murine Ischemic Full-thickness wound model	Poster	Annual Biomedical Research Conference for Minority Students (ABRCMC)	2019	Anaheim, California
Jacob D. Campbell, Vaithinathan Selvaraju, Rajesh Lakshmanan, Mahesh Thirunavukkarasu, David W. McFadden, Nilanjana Maulik. Bioengineered Nanofiber Scaffold Loaded with Resveratrol Improves Cardiac Function Following Myocardial Infarction After Four Weeks.	Talk	NESS, 25th Annual Surgical Resident and Fellow Presentation Day	2018	Waltham, MA
Gopi D. Ukani1, Jacob Campbell, Rajesh Lakhsmanan, André O’Reilly Beringhs, Vaithinathan Selvaraju, Mahesh Thirunavukkarasu, Virginia Parker, Xiuling Lu, J Alexander Palesty, Nilanjana Maulik. Utilization of a Novel Engineered Nanofibrous Scaffold Loaded with Resveratrol in a Preclinical Full Thickness Wound Model in Mice.	Talk	NESS, 25th Annual Surgical Resident and Fellow Presentation Day	2018	Waltham, MA
Campbell JD, Selvaraju V, Thirunavukkarasu M, Coca-Soliz V, Tapias L, Kurapaty Venkatapurana CM, Yee S, McFadden DW, Palesty JA, Maulik N. Pellion-1 overexpression in cardiomyocyte enhances cardiac function and attenuates ventricular remodeling in murine myocardial infarction model.	Talk	American College of Surgeons -2017 Clinical Congress	2017	San Diego, CA
Campbell JD, Selvaraju V, Lakshmanan R, Thirunavukkarasu M, McFadden DW, Maulik N. Bioengineered nanofiber scaffold loaded with resveratrol improves cardiac function following myocardial infarction: our preliminary findings.	Talk	Connecticut Chapter of the American College of Surgeons	2017	Connecticut

Title or Abstract

Type

Sponsor/Event

Date/Year

Location

Isolation and Characterization of Thioredoxin-1 Engineered Exosomes and its Role in Cardiac Function Following Myocardial Infarction

Talk

NESS, 26th Annual Surgical Resident and Fellow Presentation Day

2019

Waltham, MA

Injection of Exosomes Isolated from Thioredoxin-1 Overexpressed Mice Leads to Improved Cardiac Function and Decreased Fibrosis after Myocardial Infarction.

Talk

Clinical Congress, Americal college of Surgeons

2019

San Francisco

Resveratrol-Loaded PCL Scaffold Improves Cardiac Function after Myocardial Infarction in Mice

Poster

Clinical Congress, Americal college of Surgeons

2019

San Francisco

Bioengineered Nanofiber Scaffold Induces Healthy Wound Healing in a Murine Ischemic Full-thickness wound model

Poster

Annual Biomedical Research Conference for Minority Students (ABRCMC)

2019

Anaheim, California

Jacob D. Campbell, Vaithinathan Selvaraju, Rajesh Lakshmanan, Mahesh Thirunavukkarasu, David W. McFadden, Nilanjana Maulik. Bioengineered Nanofiber Scaffold Loaded with Resveratrol Improves Cardiac Function Following Myocardial Infarction After Four Weeks.

Talk

NESS, 25th Annual Surgical Resident and Fellow Presentation Day

2018

Waltham, MA

Gopi D. Ukani1, Jacob Campbell, Rajesh Lakhsmanan, André O’Reilly Beringhs, Vaithinathan Selvaraju, Mahesh Thirunavukkarasu, Virginia Parker, Xiuling Lu, J Alexander Palesty, Nilanjana Maulik. Utilization of a Novel Engineered Nanofibrous Scaffold Loaded with Resveratrol in a Preclinical Full Thickness Wound Model in Mice.

Talk

NESS, 25th Annual Surgical Resident and Fellow Presentation Day

2018

Waltham, MA

Campbell JD, Selvaraju V, Thirunavukkarasu M, Coca-Soliz V, Tapias L, Kurapaty Venkatapurana CM, Yee S, McFadden DW, Palesty JA, Maulik N. Pellion-1 overexpression in cardiomyocyte enhances cardiac function and attenuates ventricular remodeling in murine myocardial infarction model.

Talk

American College of Surgeons -2017 Clinical Congress

2017

San Diego, CA

Campbell JD, Selvaraju V, Lakshmanan R, Thirunavukkarasu M, McFadden DW, Maulik N. Bioengineered nanofiber scaffold loaded with resveratrol improves cardiac function following myocardial infarction: our preliminary findings.

Talk

Connecticut Chapter of the American College of Surgeons

2017

Connecticut