Faculty Directory › UConn Health

Suzy V. Torti, PhD

Professor, Department of Molecular Biology and Biophysics


Academic Office Location: Molecular Biology and Biophysics UConn Health 263 Farmington Avenue Farmington, CT
Phone:	860-679-6503
Fax:	860-679-1255
Email:	storti@uchc.edu
Website(s):	Molecular Biology & Biochemistry Graduate Program

Education & Training
Committees & Organizations
Lab Rotations
Publications
Presentations

Education

Degree	Institution	Major
BA	Reed College	Biology
PhD	Tufts University	Molecular Biology and Microbiology

Degree

Institution

Major

Reed College

Biology

PhD

Tufts University

Molecular Biology and Microbiology

Post-Graduate Training

Training	Institution	Specialty
Visiting Scholar	Stanford University	Department of Biochemistry
Postdoctoral	University of California at Berkeley	Department of Bacteriology and Immunology

Training

Institution

Specialty

Visiting Scholar

Stanford University

Department of Biochemistry

Postdoctoral

University of California at Berkeley

Department of Bacteriology and Immunology

Awards

Name of Award/Honor	Awarding Organization
Outstanding Invited Presentation, 11th World Congress on Advances in Oncology and 9th International Symposium on Molecular Medicine, Crete, Greece	Spandidos Publications
Research Excellence Award	Wake Forest University
Postdoctoral Research Fellowship	National Institutes of Health
Postdoctoral Fellowship	National Science Foundation
Summer Study Research Grant	National Science Foundation

Name of Award/Honor

Awarding Organization

Outstanding Invited Presentation, 11th World Congress on Advances in Oncology and 9th International Symposium on Molecular Medicine, Crete, Greece

Spandidos Publications

Research Excellence Award

Wake Forest University

Postdoctoral Research Fellowship

National Institutes of Health

Postdoctoral Fellowship

National Science Foundation

Summer Study Research Grant

National Science Foundation

Name & Description	Category	Role	Type	Scope	Start Year	End Year
Journal of Nanotube Therapy	Editorial Board	Member	External	National	2012
NIH Special Emphasis Panel/Scientific Review Group ZRG1 IMST-M(13)B. Small Business: Basic and Integrative Bioengineering.	Study Section	Member	External	National	2012
NIH Special Emphasis Panel/Scientific Review Group ZCA1: SRLB-C(C1)B. Cancer Imaging.	Study Section	Member	External	National	2012
Austrian Science Fund (FWF)	Advisory Committee	External Reviewer	External	International	2011
French National Institute for Health 2011 8ench-to-the-Bedside Program	Advisory Committee	Reviewer	External	International	2011
Conflict of Interest Committee,	Advisory Committee	Member	External	University	2011
Dean’s Research Advisory Committee	Advisory Committee	Chair	External	University	2011	2011
NIH Special Emphasis Panel/Scientific Review Group IMST13: Biomaterials, Delivery Systems, and Nanotechnology Small Business.	Study Section	Member	External	National	2010
Chemical Safety Committee	Advisory Committee	Member	External	University	2010
Nanomaterials Subcommittee	Advisory Committee	Member	External	University	2010
Search Committee, Senior Associate Dean for Research	Advisory Committee	Member	External	University	2010
NIH Special Emphasis Panel/Scientific Review Group; Small Business: Biomaterials, Delivery Systems, and Nanotechnology.	Study Section	Member	External	National	2009
ZRG1 Challenge Grant Panel 4, Stage 1 Reviewer, June 2009.	Study Section	Member	External	National	2009
Doctoral Task Force for Graduate Program Planning	Education Committee	Chair	External	University	2009
Graduate Student Research Day	Other	Judge	External	University	2009
National Cancer Institute Special Emphasis Panel on Biomaterials, Drug and Gene Delivery, and Nanotechnology. March 2009.	Study Section	Member	External	National	2009
Cancer Research UK	Advisory Committee	Reviewer	External	International	2008
Terry Fox Fund for Cancer Research	Advisory Committee	Reviewer	External	National	2008
AAMC Mid-Career Women's Professional Development Seminar	Professional/Scientific Organization	Member	External	National	2008
Dean's Research Advisory Committee	Advisory Committee	Member	External	University	2007	2012
Department of Biochemistry Promotions Committee	Advisory Committee	Member	External	University	2007
Dean’s Research Advisory Committee	Advisory Committee	Member	External	University	2007	2012
Medical Student Research Day	Other	Judge	External	University	2007
Louisiana Board of Regents Support Fund	Advisory Committee	Reviewer	External	State	2006
University Senate	Advisory Committee	Secretary	External	University	2006	2008
Wake Forest University Senate Executive Committee	Advisory Committee	Committee Member	External	University	2006	2008
Intramural Research Support Committee	Research Committee	Member	External	University	2006	2009
American Heart Association	Study Section	Member	External	National	2005	2008
Australian National Health and Medical Research Council	Advisory Committee	Reviewer	External	International	2005
National Institutes of Diabetes, and Digestive and Kidney Diseases Special Emphasis Panel for Program Project Review	Advisory Committee	Member	External	National	2005
Graduate School Biomedical Sciences Committee	Education Committee	Member	External	University	2005
Department of Biochemistry Graduate Program Committee	Education Committee	Chair	External	University	2005
Biochemistry and Molecular Biology Graduate Program	Education Committee	Director	External	University	2005
National Institutes of Diabetes, Digestive and Kidney Diseases RAID Review Panel	Advisory Committee	External Reviewer	External	National	2004
Wake Forest University Senate	Advisory Committee	Faculty Representative	External	University	2004	2008
Wake Forest Graduate Council	Advisory Committee	Member	External	University	2004	2008
Senate Intra-university Operations Committee	Advisory Committee	Committee Member	External	University	2004	2008
Department of Biochemistry Research-intensive Faculty Committee	Research Committee	Member	External	University	2004	2005
East Coast Iron Society	Professional/Scientific Organization	Chair	External	Regional	2003	2007
American Chemical Society Petroleum Research Fund	Advisory Committee	Reviewer	External	National	2003	2004
Israel Science Foundation	Advisory Committee	Reviewer	External	International	2003
Department of Biochemistry, Graduate Program Committee Member	Education Committee	Member	External	University	2003	2005
International Bioiron Society	Professional/Scientific Organization	Member	External	International	2003
Cancer Biology Graduate Program Committee	Advisory Committee	Member	External	University	2003
Chronic Granulomatous Disorder (CGO) Research Trust	Advisory Committee	Reviewer	External	National	2001
WFU Scientific Research Fund	Research Committee	ad hoc reviewer	External	University	2001	2002
Society for Free Radical Biology and Medicine	Professional/Scientific Journal	Member	External	National	2001
National Institutes of Health, Alcohol and Toxicology	Study Section	Member	External	National	2000
National Cancer Institute, Rapid Access to Intervention Development	Study Section	Member	External	National	2000
Intramural Research Support Committee	Research Committee	Member	External	University	2000	2003
Medical Curriculum Scholarly Project Steering Committee	Education Committee	Member	External	University	2000
Genotoxicity and Environmental Mutagen Society	Professional/Scientific Organization	Member	External	National	2000
Graduate Curriculum Committee, Cancer Biology	Education Committee	Member	External	University	1999
Medical Student Research Day	Other	Judge	External	University	1999
National Institutes of Diabetes, and Digestive and Kidney Diseases Special Emphasis Panel for Program Project Review	Advisory Committee	Reviewer	External	National	1998
Review committee, ACS Institutional Research Grant Program	Advisory Committee	Member	External	National	1998	2005
American Association for Cancer Research	Professional/Scientific Organization	Member	External	National	1998
Medical Research Council of Canada	Advisory Committee	Reviewer	External	National	1997
Research Subcommittee, Medical School Curriculum 2002 Phase III	Research Committee	Chair	External	University	1997
Steering Committee, Medical School Curriculum 2002 Phase Ill	Education Committee	Member	External	University	1997
Medical Student Admissions Committee	Education Committee	Interviewer	External	University	1994
American Society for Biochemistry and Molecular Biology	Professional/Scientific Journal	Member	External	National	1993
Veterans Administration Subcommittee on Safety for Medical Research, Palo Alto, CA	Research Committee	Chair	External	National	1990	1993
American Society for Microbiology	Professional/Scientific Journal	Member	External	National	1978
Journal of Nanomedicine & Nanotechnology	Editorial Board	Member	External	National
American Journal of Clinical Nutrition	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Apoptosis	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Biochemical Journal	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Biochemical Pharmacology	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Biomacromolecules	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Blood	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Free Radicals in Biology and Medicine	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Journal of Biological Chemistry	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Journal of Molecular Biology	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Journal of Molecular and Cellular Cardiology	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Oncogene	Professional/Scientific Journal	Ad Hoc Reviewer	External	National
Anti-Cancer Agents	Professional/Scientific Journal	Ad Hoc Reviewer	External	National

Name & Description

Journal Articles

Applying Multimodal Mass Spectrometry to Image Tumors Undergoing Ferroptosis Following In Vivo Treatment with a Ferroptosis Inducer.
Gorman, Brittney L; Taylor, Michael J; Tesfay, Lia; Lukowski, Jessica K; Hegde, Poornima; Eder, Josie G; Bloodsworth, Kent J; Kyle, Jennifer E; Torti, Suzy; Anderton, Christopher R Journal of the American Society for Mass Spectrometry 2024 Jan;35(1):5-12
Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer.
Tesfay, Lia; Paul, Bibbin T; Hegde, Poornima; Brewer, Molly; Habbani, Samrin; Jellison, Evan; Moore, Timothy; Wu, Hao; Torti, Suzy V; Torti, Frank M Scientific reports 2022 Nov;12(1):19936
Hereditary hemochromatosis variant associations with incident non-liver malignancies: 11-year follow-up in UK Biobank.
Atkins, Janice L; Pilling, Luke C; Torti, Suzy V; Torti, Frank M; Kuchel, George A; Melzer, David Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2022 Jun;
Iron and cancer: 2020 Vision.
Torti, Suzy V; Torti, Frank M Cancer research 2020 Sep;80(24):5435-5448
Systems biology of ferroptosis: A modeling approach.
Konstorum, Anna; Tesfay, Lia; Paul, Bibbin T; Torti, Frank M; Laubenbacher, Reinhard C; Torti, Suzy V Journal of theoretical biology 2020 May;493110222
Iron: The cancer connection.
Torti, Suzy V; Torti, Frank M Molecular aspects of medicine 2020 Apr;100860
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
Paul, Bibbin T; Tesfay, Lia; Winkler, C R; Torti, Frank M; Torti, Suzy V Scientific reports 2019 Dec;9(1):19634
Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death.
Tesfay, Lia; Paul, Bibbin T; Konstorum, Anna; Deng, Zhiyong; Cox, Anderson O; Lee, Jingyun; Furdui, Cristina M; Hegde, Poornima; Torti, Frank M; Torti, Suzy V Cancer Research 2019 Jul;795355-5366
A Targeted Mass Spectrometric Assay for Reliable Sensitive Hepcidin Quantification.
Moghieb, Ahmed; Tesfay, Lia; Nie, Song; Gritsenko, Marina; Fillmore, Thomas L; Jacobs, Jon M; Smith, Richard D; Torti, Frank M; Torti, Suzy V; Shi, Tujin; Ansong, Charles Scientific reports 2019 May;9(1):7264
Winning the war with iron.
Torti, Suzy V; Torti, Frank M Nature nanotechnology 2019 Mar;
Iron and Cancer.
Torti, Suzy V; Manz, David H; Paul, Bibbin T; Blanchette-Farra, Nicole; Torti, Frank M Annual review of nutrition 2018 Aug;3897-125
A Systems Biology Approach to Understanding the Pathophysiology of High-Grade Serous Ovarian Cancer: Focus on Iron and Fatty Acid Metabolism.
Konstorum, Anna; Lynch, Miranda L; Torti, Suzy V; Torti, Frank M; Laubenbacher, Reinhard C Omics : a journal of integrative biology 2018 Jul;22(7):502-513
Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer.
Blanchette-Farra, Nicole; Kita, Daniel; Konstorum, Anna; Tesfay, Lia; Lemler, David; Hegde, Poornima; Claffey, Kevin P; Torti, Frank M; Torti, Suzy V Oncogene 2018 Apr;374013-4032
Effects of ferroportin-mediated iron depletion in cells representative of different histological subtypes of prostate cancer.
Deng, Zhiyong; Manz, David H; Torti, Suzy; Torti, Frank M Antioxidants & redox signaling 2017 Oct;
Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth.
Deng, Zhiyong; Manz, David H; Torti, Suzy V; Torti, Frank M Oncotarget 2017 Jul;
Iron addiction: a novel therapeutic target in ovarian cancer.
Basuli, D; Tesfay, L; Deng, Z; Paul, B; Yamamoto, Y; Ning, G; Xian, W; McKeon, F; Lynch, M; Crum, C P; Hegde, P; Brewer, M; Wang, X; Miller, L D; Dyment, N; Torti, F M; Torti, S V Oncogene 2017 Mar;364089-4099
DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.
Lemler, David J; Lynch, Miranda L; Tesfay, Lia; Deng, Zhiyong; Paul, Bibbin T; Wang, Xiaohong; Hegde, Poornima; Manz, David H; Torti, Suzy V; Torti, Frank M Breast cancer research : BCR 2017 Mar;19(1):25
Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective.
Chifman, Julia; Arat, Seda; Deng, Zhiyong; Lemler, Erica; Pino, James C; Harris, Leonard A; Kochen, Michael A; Lopez, Carlos F; Akman, Steven A; Torti, Frank M; Torti, Suzy V; Laubenbacher, Reinhard PLoS computational biology 2017 Feb;13(2):e1005352
Mitochondria and Iron: current questions.
Paul, Bibbin T; Manz, David H; Torti, Frank M; Torti, Suzy V Expert review of hematology 2017 Jan;10(1):65-79
Iron and cancer: recent insights.
Manz, David H; Blanchette, Nicole L; Paul, Bibbin T; Torti, Frank M; Torti, Suzy V Annals of the New York Academy of Sciences 2016 Feb;1368149-61
Modulation of hepcidin to treat iron deregulation: potential clinical applications.
Blanchette, Nicole L; Manz, David H; Torti, Frank M; Torti, Suzy V Expert review of hematology 2015 Dec;9169-86
In Vitro and In Vivo Correlates of Physiologic and Neoplastic Human Fallopian Tube Stem Cells.
Yamamoto, Yusuke; Ning, Gang; Howitt, Brooke E; Mehra, Karishma; Wu, Lingyan; Wang, Xia; Hong, Yue; Kern, Florian; Wei, Tay Seok; Zhang, Ting; Nagarajan, Niranjan; Basuli, Debargha; Torti, Suzy; Brewer, Molly; Choolani, Mahesh; McKeon, Frank; Crum, Christopher P; Xian, Wa The Journal of pathology 2015 Sep;238519-530
Targeting breast cancer with sugar-coated carbon nanotubes.
Fahrenholtz, Cale D; Hadimani, Mallinath; King, S Bruce; Torti, Suzy V; Singh, Ravi Nanomedicine (London, England) 2015 Aug;10(16):2481-97
Yet another function of p53--the switch that determines whether radiation-induced autophagy will be cytoprotective or nonprotective: implications for autophagy inhibition as a therapeutic strategy.
Chakradeo, Shweta; Sharma, Khushboo; Alhaddad, Aisha; Bakhshwin, Duaa; Le, Ngoc; Harada, Hisashi; Nakajima, Wataru; Yeudall, W Andrew; Torti, Suzy V; Torti, Frank M; Gewirtz, David A Molecular pharmacology 2015 May;87(5):803-14
Hepcidin regulation in prostate and its disruption in prostate cancer.
Tesfay, Lia; Clausen, Kathryn A; Kim, Jin Woo; Hegde, Poornima; Wang, Xiaohong; Miller, Lance D; Deng, Zhiyong; Blanchette, Nicole; Arvedson, Tara; Miranti, Cindy K; Babitt, Jodie L; Lin, Herbert Y; Peehl, Donna M; Torti, Frank M; Torti, Suzy V Cancer research 2015 Apr;75(11):2254-63
IRP2 regulates breast tumor growth.
Wang, Wei; Deng, Zhiyong; Hatcher, Heather; Miller, Lance D; Di, Xiumin; Tesfay, Lia; Sui, Guangchao; D'Agostino, Ralph B; Torti, Frank M; Torti, Suzy V Cancer research 2014 Jan;74(2):497-507
Epidemiological associations between iron and cardiovascular disease and diabetes.
Basuli, Debargha; Stevens, Richard G; Torti, Frank M; Torti, Suzy V Frontiers in pharmacology 2014 Jan;5117
Ferritin H is a novel marker of early erythroid precursors and macrophages.
Wang, Wei; Grier, David D; Woo, Jennifer; Ward, Martha; Sui, Guangchao; Torti, Suzy V; Torti, Frank M; Beaty, Michael W Histopathology 2013 May;62(6):931-40
Iron and cancer: more ore to be mined.
Torti, Suzy V; Torti, Frank M Nature reviews. Cancer 2013 May;13(5):342-55
Spatial and temporal measurements of temperature and cell viability in response to nanoparticle-mediated photothermal therapy.
Whitney, Jon R; Rodgers, Amanda; Harvie, Erica; Carswell, William F; Torti, Suzy; Puretzky, Alex A; Rouleau, Christopher M; Geohegan, David B; Rylander, Christopher G; Rylander, Marissa N Nanomedicine (London, England) 2012 Nov;7(11):1729-42
Heat localization for targeted tumor treatment with nanoscale near-infrared radiation absorbers.
Xie, Bin; Singh, Ravi; Torti, F M; Keblinski, Pawel; Torti, Suzy Physics in medicine and biology 2012 Sep;57(18):5765-75
Hybrid 2D nanomaterials as dual-mode contrast agents in cellular imaging.
Narayanan, Tharangattu N; Gupta, Bipin K; Vithayathil, Sajna A; Aburto, Rebeca R; Mani, Sendurai A; Taha-Tijerina, Jaime; Xie, Bin; Kaipparettu, Benny A; Torti, Suzy V; Ajayan, Pulickel M Advanced materials (Deerfield Beach, Fla.) 2012 Jun;24(22):2992-8
The core control system of intracellular iron homeostasis: a mathematical model.
Chifman, J; Kniss, A; Neupane, P; Williams, I; Leung, B; Deng, Z; Mendes, P; Hower, V; Torti, F M; Akman, S A; Torti, S V; Laubenbacher, R Journal of theoretical biology 2012 May;30091-9
Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27.
Wan, Meimei; Huang, Weiwei; Kute, Timothy E; Miller, Lance D; Zhang, Qiang; Hatcher, Heather; Wang, Jingxuan; Stovall, Daniel B; Russell, Gregory B; Cao, Paul D; Deng, Zhiyong; Wang, Wei; Zhang, Qingyuan; Lei, Ming; Torti, Suzy V; Akman, Steven A; Sui, Guangchao The American journal of pathology 2012 May;180(5):2120-33
The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy.
Burke, Andrew R; Singh, Ravi N; Carroll, David L; Wood, James C S; D'Agostino, Ralph B; Ajayan, Pulickel M; Torti, Frank M; Torti, Suzy V Biomaterials 2012 Apr;33(10):2961-70
Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells.
Tesfay, Lia; Huhn, Annissa J; Hatcher, Heather; Torti, Frank M; Torti, Suzy V PloS one 2012 Jan;7(7):e40030
An iron regulatory gene signature predicts outcome in breast cancer.
Miller, Lance D; Coffman, Lan G; Chou, Jeff W; Black, Michael A; Bergh, Jonas; D'Agostino, Ralph; Torti, Suzy V; Torti, Frank M Cancer research 2011 Nov;71(21):6728-37
Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy.
Ding, Xuanfeng; Singh, Ravi; Burke, Andrew; Hatcher, Heather; Olson, John; Kraft, Robert A; Schmid, Michael; Carroll, David; Bourland, J Daniel; Akman, Steven; Torti, Frank M; Torti, Suzy V Nanomedicine (London, England) 2011 Oct;6(8):1341-52
SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer.
Clausen, Kathryn A; Blish, Kimberly R; Birse, Charles E; Triplette, Matthew A; Kute, Timothy E; Russell, Gregory B; D'Agostino, Ralph B; Miller, Lance D; Torti, Frank M; Torti, Suzy V Breast cancer research and treatment 2011 Oct;129(3):737-46
Bioinformatics tools for cancer metabolomics.
Blekherman, Grigoriy; Laubenbacher, Reinhard; Cortes, Diego F; Mendes, Pedro; Torti, Frank M; Akman, Steven; Torti, Suzy V; Shulaev, Vladimir Metabolomics : Official journal of the Metabolomic Society 2011 Sep;7(3):329-343
Determinants of the thrombogenic potential of multiwalled carbon nanotubes.
Burke, Andrew R; Singh, Ravi N; Carroll, David L; Owen, John D; Kock, Nancy D; D'Agostino, Ralph; Torti, Frank M; Torti, Suzy V Biomaterials 2011 Sep;32(26):5970-8
Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress.
Cortes, Diego F; Sha, Wei; Hower, Valerie; Blekherman, Greg; Laubenbacher, Reinhard; Akman, Steven; Torti, Suzy V; Shulaev, Vladimir Free radical biology & medicine 2011 Jun;50(11):1565-74
Ironing out cancer.
Torti, Suzy V; Torti, Frank M Cancer research 2011 Mar;71(5):1511-4
Bioinformatics tools for cancer metabolomics
G. Blekherman, R. Laubenbacher, D. Cortes, P. Mendes, F. Torti, S. Akman, S. Torti,and V. Shulaev Metabolomics 2011 Jan;7(3):329- 243
Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells.
Han, Jian; Seaman, William E; Di, Xiumin; Wang, Wei; Willingham, Mark; Torti, Frank M; Torti, Suzy V PloS one 2011 Jan;6(8):e23800
Photothermal response of human and murine cancer cells to multiwalled carbon nanotubes after laser irradiation.
Fisher, Jessica W; Sarkar, Saugata; Buchanan, Cara F; Szot, Christopher S; Whitney, Jon; Hatcher, Heather C; Torti, Suzy V; Rylander, Christopher G; Rylander, Marissa Nichole Cancer research 2010 Dec;70(23):9855-64
Ferroportin and iron regulation in breast cancer progression and prognosis.
Pinnix, Zandra K; Miller, Lance D; Wang, Wei; D'Agostino, Ralph; Kute, Tim; Willingham, Mark C; Hatcher, Heather; Tesfay, Lia; Sui, Guangchao; Di, Xiumin; Torti, Suzy V; Torti, Frank M Science translational medicine 2010 Aug;2(43):43ra56
Ferritin H induction by histone deacetylase inhibitors.
Wang, Wei; Di, Xiumin; Torti, Suzy V; Torti, Frank M Biochemical pharmacology 2010 Aug;80(3):316-24
Serum ferritin: Past, present and future.
Wang, Wei; Knovich, Mary Ann; Coffman, Lan G; Torti, Frank M; Torti, Suzy V Biochimica et biophysica acta 2010 Aug;1800(8):760-9
Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode.
Neal, Robert E; Singh, Ravi; Hatcher, Heather C; Kock, Nancy D; Torti, Suzy V; Davalos, Rafael V Breast cancer research and treatment 2010 Aug;123(1):295-301
Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.
Li, Li; Fang, Celia J; Ryan, James C; Niemi, Eréne C; Lebrón, José A; Björkman, Pamela J; Arase, Hisashi; Torti, Frank M; Torti, Suzy V; Nakamura, Mary C; Seaman, William E Proceedings of the National Academy of Sciences of the United States of America 2010 Feb;107(8):3505-10
Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors.
Blish, Kimberly R; Clausen, Kathryn A; Hawkins, Gregory A; Garvin, A Julian; Willingham, Mark C; Turner, Julie C; Torti, Frank M; Torti, Suzy V Journal of experimental & clinical cancer research : CR 2010 Jan;29147
A systems biology view of cancer.
Laubenbacher, Reinhard; Hower, Valerie; Jarrah, Abdul; Torti, Suzy V; Shulaev, Vladimir; Mendes, Pedro; Torti, Frank M; Akman, Steven Biochimica et biophysica acta 2009 Dec;1796(2):129-39
Synthetic and natural iron chelators: therapeutic potential and clinical use.
Hatcher, Heather C; Singh, Ravi N; Torti, Frank M; Torti, Suzy V Future medicinal chemistry 2009 Dec;1(9):1643-70
Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation.
Burke, Andrew; Ding, Xuanfeng; Singh, Ravi; Kraft, Robert A; Levi-Polyachenko, Nicole; Rylander, Marissa Nichole; Szot, Chris; Buchanan, Cara; Whitney, Jon; Fisher, Jessica; Hatcher, Heather C; D'Agostino, Ralph; Kock, Nancy D; Ajayan, P M; Carroll, David L; Akman, Steven; Torti, Frank M; Torti, Suzy V Proceedings of the National Academy of Sciences of the United States of America 2009 Aug;106(31):12897-902
BMP signaling and podocyte markers are decreased in human diabetic nephropathy in association with CTGF overexpression.
Turk, Tamara; Leeuwis, Jan Willem; Gray, Julia; Torti, Suzy V; Lyons, Karen M; Nguyen, Tri Q; Goldschmeding, Roel The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Jul;57(7):623-31
A general map of iron metabolism and tissue-specific subnetworks.
Hower, Valerie; Mendes, Pedro; Torti, Frank M; Laubenbacher, Reinhard; Akman, Steven; Shulaev, Vladmir; Torti, Suzy V Molecular bioSystems 2009 May;5(5):422-43
Ferritin for the clinician.
Knovich, Mary Ann; Storey, Jonathan A; Coffman, Lan G; Torti, Suzy V; Torti, Frank M Blood reviews 2009 May;23(3):95-104
Preparation of Disubstituted Phenyl Propargyl Alcohols, their Use in Oxathiolene Oxide Synthesis, and Evaluation of the Oxathiolene Oxide Products as Anticarcinogenic Enzyme Inducers.
Ying, Maben; Smentek, Matthew G; Ma, Rong; Day, Cynthia S; Torti, Suzy V; Welker, Mark E Letters in organic chemistry 2009 Apr;6(3):242-251
Regulatory effects of ferritin on angiogenesis.
Coffman, Lan G; Parsonage, Derek; D'Agostino, Ralph; Torti, Frank M; Torti, Suzy V Proceedings of the National Academy of Sciences of the United States of America 2009 Jan;106(2):570-5
Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator.
Jiao, Yan; Wilkinson, John; Di, Xiumin; Wang, Wei; Hatcher, Heather; Kock, Nancy D; D'Agostino, Ralph; Knovich, Mary Ann; Torti, Frank M; Torti, Suzy V Blood 2009 Jan;113(2):462-9
The transplant iron score as a predictor of stem cell transplant survival.
Storey, Jonathan A; Connor, Rebecca F; Lewis, Zachary T; Hurd, David; Pomper, Gregory; Keung, Yi K; Grover, Manisha; Lovato, James; Torti, Suzy V; Torti, Frank M; Molnár, István Journal of hematology & oncology 2009 Jan;244
Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest.
Zhang, Fan; Wang, Wei; Tsuji, Yoshiaki; Torti, Suzy V; Torti, Frank M The Journal of biological chemistry 2008 Dec;283(49):33911-8
Curcumin: from ancient medicine to current clinical trials.
Hatcher, H; Planalp, R; Cho, J; Torti, F M; Torti, S V Cellular and molecular life sciences : CMLS 2008 Jun;65(11):1631-52
Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin.
Coffman, Lan G; Brown, Julie C; Johnson, David A; Parthasarathy, Narayanan; D'Agostino, Ralph B; Lively, Mark O; Hua, Xiaoyang; Tilley, Stephen L; Muller-Esterl, Werner; Willingham, Mark C; Torti, Frank M; Torti, Suzy V American journal of physiology. Lung cellular and molecular physiology 2008 Mar;294(3):L505-15
A human bone morphogenetic protein antagonist is down-regulated in renal cancer.
Blish, Kimberly Rose; Wang, Wei; Willingham, Mark C; Du, Wei; Birse, Charles E; Krishnan, Surekha R; Brown, Julie C; Hawkins, Gregory A; Garvin, A Julian; D'Agostino, Ralph B; Torti, Frank M; Torti, Suzy V Molecular biology of the cell 2008 Feb;19(2):457-64
Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators.
Childers, Matt L; Cho, Joonhyung; Regino, Celeste A S; Brechbiel, Martin W; DiPasquale, Antonio G; Rheingold, Arnold L; Torti, Suzy V; Torti, Frank M; Planalp, Roy P Journal of inorganic biochemistry 2008 Jan;102(1):150-6
Excess capacity of the iron regulatory protein system.
Wang, Wei; Di, Xiumin; D'Agostino, Ralph B; Torti, Suzy V; Torti, Frank M The Journal of biological chemistry 2007 Aug;282(34):24650-9
Thermal ablation therapeutics based on CN(x) multi-walled nanotubes.
Torti, Suzy V; Byrne, Fiona; Whelan, Orla; Levi, Nicole; Ucer, Burak; Schmid, Michael; Torti, Frank M; Akman, Steven; Liu, Jiwen; Ajayan, Pulickel M; Nalamasu, Omkaram; Carroll, David L International journal of nanomedicine 2007 Jan;2(4):707-14
Coordinate inhibition of cytokine-mediated induction of ferritin H, manganese superoxide dismutase, and interleukin-6 by the adenovirus E1A oncogene.
Jennings-Gee, Jamie E; Tsuji, Yoshiaki; Pietsch, E Christine; Moran, Elizabeth; Mymryk, J S; Torti, Frank M; Torti, Suzy V The Journal of biological chemistry 2006 Jun;281(24):16428-35
Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo.
Wilkinson, John; Di, Xiumin; Schönig, Kai; Buss, Joan L; Kock, Nancy D; Cline, J Mark; Saunders, Thomas L; Bujard, Hermann; Torti, Suzy V; Torti, Frank M The Biochemical journal 2006 May;395(3):501-7
Iron chelation in the biological activity of curcumin.
Jiao, Yan; Wilkinson, John; Christine Pietsch, E; Buss, Joan L; Wang, Wei; Planalp, Roy; Torti, Frank M; Torti, Suzy V Free radical biology & medicine 2006 Apr;40(7):1152-60
N-picolyl derivatives of Kemp's triamine as potential antitumor agents: a preliminary investigation.
Regino, Celeste Aida S; Torti, Suzy V; Ma, Rong; Yap, Glenn P A; Kreisel, Kevin A; Torti, Frank M; Planalp, Roy P; Brechbiel, Martin W Journal of medicinal chemistry 2005 Dec;48(25):7993-9
Preliminary evaluation of the cytotoxicity of a series of tris-2-aminoethylamine (Tren) based hexadentate heterocyclic donor agents.
Torti, Suzy V; Ma, Rong; Venditto, Vincent J; Torti, Frank M; Planalp, Roy P; Brechbiel, Martin W Bioorganic & medicinal chemistry 2005 Nov;13(21):5961-7
Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation.
Turner, Jolyn; Koumenis, Constantinos; Kute, Timothy E; Planalp, Roy P; Brechbiel, Martin W; Beardsley, Dillon; Cody, Brooke; Brown, Kevin D; Torti, Frank M; Torti, Suzy V Blood 2005 Nov;106(9):3191-9
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
Chen, Thomas T; Li, Li; Chung, Dong-Hui; Allen, Christopher D C; Torti, Suzy V; Torti, Frank M; Cyster, Jason G; Chen, Chih-Ying; Brodsky, Frances M; Niemi, Eréne C; Nakamura, Mary C; Seaman, William E; Daws, Michael R The Journal of experimental medicine 2005 Oct;202(7):955-65
A novel phospholipid gemcitabine conjugate is able to bypass three drug-resistance mechanisms.
Alexander, Richard L; Greene, Bryan T; Torti, Suzy V; Kucera, Gregory L Cancer chemotherapy and pharmacology 2005 Jul;56(1):15-21
Oxathiolene oxide synthesis via chelation-controlled addition of organometallic reagents to alkynols followed by addition of sulfur electrophiles and evaluation of oxathiolene oxides as anticarcinogenic enzyme inducers.
Franks, Marion A; Schrader, Edward A; Pietsch, E Christine; Pennella, Daniel R; Torti, Suzy V; Welker, Mark E Bioorganic & medicinal chemistry 2005 Mar;13(6):2221-33
Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species.
Pham, Can G; Bubici, Concetta; Zazzeroni, Francesca; Papa, Salvatore; Jones, Joy; Alvarez, Kellean; Jayawardena, Shanthi; De Smaele, Enrico; Cong, Rong; Beaumont, Carole; Torti, Frank M; Torti, Suzy V; Franzoso, Guido Cell 2004 Nov;119(4):529-42
Synthesis and potent antitumor activities of novel 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives.
Chong, Hyun-Soon; Torti, Suzy V; Ma, Rong; Torti, Frank M; Brechbiel, Martin W Journal of medicinal chemistry 2004 Oct;47(21):5230-4
Nickel(II), copper(II) and zinc(II) binding properties and cytotoxicity of tripodal, hexadentate tris(ethylenediamine)--analogue chelators.
Ye, Neng; Park, Gyungse; Przyborowska, Ann M; Sloan, Paula E; Clifford, Thomas; Bauer, Cary B; Broker, Grant A; Rogers, Robin D; Ma, Rong; Torti, Suzy V; Brechbiel, Martin W; Planalp, Roy P Dalton transactions (Cambridge, England : 2003) 2004 May;(9):1304-11
Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator.
Zhao, Rong; Planalp, Roy P; Ma, Rong; Greene, Bryan T; Jones, Bradley T; Brechbiel, Martin W; Torti, Frank M; Torti, Suzy V Biochemical pharmacology 2004 May;67(9):1677-88
Iron chelators in cancer chemotherapy.
Buss, Joan L; Greene, Bryan T; Turner, Jolyn; Torti, Frank M; Torti, Suzy V Current topics in medicinal chemistry 2004 Jan;4(15):1623-35
The role of iron chelation in cancer therapy.
Buss, Joan L; Torti, Frank M; Torti, Suzy V Current medicinal chemistry 2003 Jun;10(12):1021-34
Oxathiolene oxides: a novel family of compounds that induce ferritin, glutathione S-transferase, and other proteins of the phase II response.
Pietsch, E Christine; Hurley, Allison L; Scott, Elizabeth E; Duckworth, Benjamin P; Welker, Mark E; Leone-Kabler, Sandra; Townsend, Alan J; Torti, Frank M; Torti, Suzy V Biochemical pharmacology 2003 Apr;65(8):1261-9
Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.
Pietsch, E Christine; Chan, Jefferson Y; Torti, Frank M; Torti, Suzy V The Journal of biological chemistry 2003 Jan;278(4):2361-9
Ferritin regulation by oxidants and chemopreventive xenobiotics.
Wilkinson, John; Pietsch, E Christine; Torti, Suzy V; Torti, Frank M Advances in enzyme regulation 2003 Jan;43135-51
Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress.
Thompson, Khristy; Menzies, Sharon; Muckenthaler, Martina; Torti, Frank M; Wood, Teresa; Torti, Suzy V; Hentze, Matthias W; Beard, John; Connor, James Journal of neuroscience research 2003 Jan;71(1):46-63
Synthesis of 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives as potential antitumor agents.
Chong, Hyun-soon; Torti, Frank M; Torti, Suzy V; Brechbiel, Martin W The Journal of organic chemistry 2002 Nov;67(23):8072-8
Novel cytotoxic chelators that bind iron(II) selectively over zinc(II) under aqueous aerobic conditions.
Planalp, R P; Przyborowska, A M; Park, G; Ye, N; Lu, F H; Rogers, R D; Broker, G A; Torti, S V; Brechbiel, M W Biochemical Society transactions 2002 Aug;30(4):758-62
Activation of caspase pathways during iron chelator-mediated apoptosis.
Greene, Bryan T; Thorburn, Jackie; Willingham, Mark C; Thorburn, Andrew; Planalp, Roy P; Brechbiel, Martin W; Jennings-Gee, Jamie; Wilkinson, John; Torti, Frank M; Torti, Suzy V The Journal of biological chemistry 2002 Jul;277(28):25568-75
Ferritin binds to light chain of human H-kininogen and inhibits kallikrein-mediated bradykinin release.
Parthasarathy, Narayanan; Torti, Suzy V; Torti, Frank M The Biochemical journal 2002 Jul;365(Pt 1):279-86
Regulation of ferritin genes and protein.
Torti, Frank M; Torti, Suzy V Blood 2002 May;99(10):3505-16
Use of green fluorescent protein to measure tumor growth in an implanted bladder tumor model.
Torti, Suzy V; Golden-Fleet, Meg; Willingham, Mark C; Ma, Rong; Cline, Mark; Sakimoto, Yoshiro; Torti, Frank M The Journal of urology 2002 Feb;167(2 Pt 1):724-8
p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator.
Abeysinghe, R D; Greene, B T; Haynes, R; Willingham, M C; Turner, J; Planalp, R P; Brechbiel, M W; Torti, F M; Torti, S V Carcinogenesis 2001 Oct;22(10):1607-14
Ferritin and the response to oxidative stress.
Orino, K; Lehman, L; Tsuji, Y; Ayaki, H; Torti, S V; Torti, F M The Biochemical journal 2001 Jul;357(Pt 1):241-7
Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress.
Tsuji, Y; Ayaki, H; Whitman, S P; Morrow, C S; Torti, S V; Torti, F M Molecular and cellular biology 2000 Aug;20(16):5818-27
Adenovirus E1A blocks oxidant-dependent ferritin induction and sensitizes cells to pro-oxidant cytotoxicity.
Orino, K; Tsuji, Y; Torti, F M; Torti, S V FEBS letters 1999 Nov;461(3):334-8
Transcriptional regulation of the mouse ferritin H gene. Involvement of p300/CBP adaptor proteins in FER-1 enhancer activity.
Tsuji, Y; Moran, E; Torti, S V; Torti, F M The Journal of biological chemistry 1999 Mar;274(11):7501-7
Tumor cell cytotoxicity of a novel metal chelator.
Torti, S V; Torti, F M; Whitman, S P; Brechbiel, M W; Park, G; Planalp, R P Blood 1998 Aug;92(4):1384-9
Selective inhibition of muscle gene expression by oxidative stress in cardiac cells.
Torti, S V; Akimoto, H; Lin, K; Billingham, M E; Torti, F M Journal of molecular and cellular cardiology 1998 Jun;30(6):1173-80
Human H-kininogen is a ferritin-binding protein.
Torti, S V; Torti, F M The Journal of biological chemistry 1998 May;273(22):13630-5
Activation of the ferritin H enhancer, FER-1, by the cooperative action of members of the AP1 and Sp1 transcription factor families.
Tsuji, Y; Torti, S V; Torti, F M The Journal of biological chemistry 1998 Jan;273(5):2984-92
Novel Iron Complexes and Chelators Based on cis, cis-1,3,5-Triaminocyclohexane: Iron-mediated Ligand Oxidation and Biochemical Properties.
Park G, Lu FH, Ye N, Brechbiel MW, Torti SV, Torti FM, Planalp RP. J Biol Inorg Chem 1998 Jan;3449-457
Recombinant ferritin: modulation of subunit stoichiometry in bacterial expression systems.
Rucker, P; Torti, F M; Torti, S V Protein engineering 1997 Aug;10(8):967-73
Role of H and L subunits in mouse ferritin.
Rucker, P; Torti, F M; Torti, S V The Journal of biological chemistry 1996 Dec;271(52):33352-7
Novel properties of L-type polypeptide subunits in mouse ferritin molecules.
Beaumont, C; Torti, S V; Torti, F M; Massover, W H The Journal of biological chemistry 1996 Apr;271(14):7923-6
FER-1, an enhancer of the ferritin H gene and a target of E1A-mediated transcriptional repression.
Tsuji, Y; Akebi, N; Lam, T K; Nakabeppu, Y; Torti, S V; Torti, F M Molecular and cellular biology 1995 Sep;15(9):5152-64
Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alpha.
Kwak, E L; Larochelle, D A; Beaumont, C; Torti, S V; Torti, F M The Journal of biological chemistry 1995 Jun;270(25):15285-93
Cytokines, iron homeostasis, and cancer.
Torti, F M; Torti, S V Advances in experimental medicine and biology 1994 Jan;354161-70
Iron and ferritin in inflammation and cancer.
Torti, S V; Torti, F M Advances in inorganic biochemistry 1994 Jan;10119-37
Selective loss of CDC2 and CDK2 induction by tumor necrosis factor-alpha in senescent human diploid fibroblasts.
Tsuji, Y; Ninomiya-Tsuji, J; Torti, S V; Torti, F M Experimental cell research 1993 Dec;209(2):175-82
Effect of verapamil on doxorubicin cardiotoxicity: altered muscle gene expression in cultured neonatal rat cardiomyocytes.
Akimoto, H; Bruno, N A; Slate, D L; Billingham, M E; Torti, S V; Torti, F M Cancer research 1993 Oct;53(19):4658-64
N-acetyl-L-cysteine protects endothelial cells but not L929 tumor cells from tumor necrosis factor-alpha-mediated cytotoxicity.
Schröder, H; Warren, S; Bargetzi, M J; Torti, S V; Torti, F M Naunyn-Schmiedeberg's archives of pharmacology 1993 Jun;347(6):664-6
Preferential repression of the H subunit of ferritin by adenovirus E1A in NIH-3T3 mouse fibroblasts.
Tsuji, Y; Kwak, E; Saika, T; Torti, S V; Torti, F M The Journal of biological chemistry 1993 Apr;268(10):7270-5
The role of iron in the cytotoxicity of tumor necrosis factor.
Warren, S; Torti, S V; Torti, F M Lymphokine and cytokine research 1993 Apr;12(2):75-80
Augmentation by IL-1 alpha of tumor necrosis factor-alpha cytotoxicity in cells transfected with adenovirus E1A.
Tsuji, Y; Ninomiya-Tsuji, J; Torti, S V; Torti, F M Journal of immunology (Baltimore, Md. : 1950) 1993 Mar;150(5):1897-907
Evaluation of mRNA levels by the polymerase chain reaction in small cardiac tissue samples.
Ito, H; Miller, S C; Akimoto, H; Torti, S V; Taylor, A; Billingham, M E; Torti, F M Journal of molecular and cellular cardiology 1991 Oct;23(10):1117-25
Iron-independent induction of ferritin H chain by tumor necrosis factor.
Miller, L L; Miller, S C; Torti, S V; Tsuji, Y; Torti, F M Proceedings of the National Academy of Sciences of the United States of America 1991 Jun;88(11):4946-50
Tumor necrosis factor-alpha and interleukin 1-alpha regulate transferrin receptor in human diploid fibroblasts. Relationship to the induction of ferritin heavy chain.
Tsuji, Y; Miller, L L; Miller, S C; Torti, S V; Torti, F M The Journal of biological chemistry 1991 Apr;266(11):7257-61
Murine ferritin heavy chain: isolation and characterization of a functional gene.
Kwak, E L; Torti, S V; Torti, F M Gene 1990 Oct;94(2):255-61
Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro.
Ito, H; Miller, S C; Billingham, M E; Akimoto, H; Torti, S V; Wade, R; Gahlmann, R; Lyons, G; Kedes, L; Torti, F M Proceedings of the National Academy of Sciences of the United States of America 1990 Jun;87(11):4275-9
Interleukin 1 induces ferritin heavy chain in human muscle cells.
Wei, Y; Miller, S C; Tsuji, Y; Torti, S V; Torti, F M Biochemical and biophysical research communications 1990 May;169(1):289-96
Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta.
Torti, F M; Torti, S V; Larrick, J W; Ringold, G M The Journal of cell biology 1989 Mar;108(3):1105-13
The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene.
Torti, S V; Kwak, E L; Miller, S C; Miller, L L; Ringold, G M; Myambo, K B; Young, A P; Torti, F M The Journal of biological chemistry 1988 Sep;263(25):12638-44
Genetic characterization of aggregation-defective developmental mutants of Myxococcus xanthus.
Torti, S; Zusman, D R Journal of bacteriology 1981 Sep;147(3):768-75
Genetic characterization of a filament-forming, lipoprotein-deficient mutant of Escherichia coli.
Torti, S; Park, J T Journal of bacteriology 1980 Sep;143(3):1289-94
Lipoprotein of gram-negative bacteria is essential for growth and division.
Torti, S V; Park, J T Nature 1976 Sep;263(5575):323-6

Book Chapters

Bifunctional nanomaterials for the imaging and treatment of cancer.
Burke A, Carroll D, Torti FM, and Torti SV. The Oxford Handbook of Nanoscience and Technology – Frontiers and Advances in three volumes, Volume III, Applications 2010 Jan;474-497
Iron Chelators in Cancer Chemotherapy, Vol. 4, Number 15
Buss, J., Green, B., Turner, J., Torti, F.M., and Torti, SV. Metals in Disease and Therapy, CTMC Reviews 2004 Jan;1623-1635
Iron Chelation in Cancer Therapy.
Torti SV, Planalp RP, Brechbiel MW, Park G, Torti FM. Molecular Biology of Hematopoiesis 6 1999 Jan;381-389
Cytokines, iron homeostasis, and cancer.
Torti, F.M., and Torti, S.V. Diet and Cancer; Markers, Prevention and Treatment 1994 Jan;159-168

Abstracts

Ferritin inhibits cleavage of high molecular weight kininogen by elastase and mast cell tryptase.
Coffman, L.G., Brown, J., Johnson, D., Parthasarathy, N., D'Agostino, Jr. R., Muller-Esterl, W., Torti, F., and Torti, S. American Journal of Hematology 2006 Jan;82(6):504-604
Perturbations of H-ferritin in mice results in alterations in brain iron homeostasis
Thompson K, Menzies S, Wood T, Boyer PJ, Beard JL, Torti S, Torti F, Connor JR 2001 Jan;15A579.3
Analytical and pharmacokinetic studies in mice with tachpyr.
Hale, J., Bigelow, J., Mathews, L., McCormack, J.J., Torti, S., Torti, F., Brechbiel, M., and Planalp, R. Proc. Amer. Assoc. Cancer Res 2000 Jan;41705
Oxathiolene oxides: a novel class of potential chemopreventive agents.
Pietsch, E.C., Hurley, A.l., Leone-Kabler, S., Welker, M.E., Townsend, A.J., Torti, F.M., and Torti,S.V. Proc. Amer. Assoc. Cancer Res. 2000 Jan;41411
Pathways of iron chelator action.
Torti, S.V., Abeysinghe, RD., Greene, 8., Willingham, M.C., Sausville, E.A., Narayanan, V., Planalp, R.P., Brechbiel, M.W. and Torti, F.M. FASEB J. 2000 Jan;14A752
Tachpyridine (Tachpyr), a novel iron chelator and a potential anti-cancer agent in the treatment of tumors with mutated p53.
Abeysinghe, RD., Greene, B., Willingham, M.C., Sausville, E.A., Narayanan, V.l., Planalp, R.P., Brechbiel, M.W., Torti, F.M., and Torti, S.V. Proc. Amer. Assoc. Cancer Res. 2000 Jan;41771
A novel iron chelator with potential anti-tumor activity leads to cell death by apoptosis.
Jennings-Gee, J.E., Willingham, M.C., Planalp, RP., Brechbiel, M.W., Torti, F.M., and Torti, S.V. Proc. Amer. Assoc. Cancer Res. 1999 Jan;40120
Oltipraz-mediated induction of ferritin expression.
Pietsch, E.C., Morrow, C., Torti, F.M., and Torti, S.V. Proc. Amer. Assoc. Cancer Res. 1999 Jan;40258
Metalchelation in bladder cancer therapy.
Torti, S.V., Planalp, RP., Sakamoto, Y., Brechbiel, M.W., Rogers, RD., and Torti, F.M. Acta Hematologica 1998 Jan;100(suppl. 1):55
The ferritin H gene is amplified in human breast cancer carrying an 11 q13 amplification, as demonstrated by fluorescence in situ hybridization.
Abruzzese, E., Rao, P.N., Petenati, M.J., Kute, T., Torti, F.M. and Torti, s.v. Acta Hematologica 1998 Jan;100 (suppl. 1):55
Transcriptional regulation of H ferritin by a distal antioxidant response element.
Whitman, S.P., Tsuji, Y.T., Torti, S.V, and Torti, F.M. Proc. Amer. Assoc. Cancer Res. 1998 Jan;39247
The ferritin H gene is amplified in human breast cancers carrying an 11q13 amplification.
Abruzzese E., Rao, P.N., Pettenati M.J., Kute T., Torti S.V., and Torti F.M. Proc. Arner. Assoc. Cancer Res. 1997 Jan;3817
Utilization of fluorescense in situ hybridization to study the ferritin H gene in metaphase and interphase cells
Abruzzese E, Rao PN, Hayworth R, Pettenati MJ, Torti SV, Torti FM Blood 1995 Jan;86(10):723a

Conference Papers

A Novel, Human BMP Antagonist Downregulated in Breast and Renal Cancers
Torti SV 2006 Jan;
Metal complexation behavior and cytotoxicity of novel hexadentate chelators.
Planalp, RP.; Park, G., Brechbiei, M.W., and Torti, S.V. 1999 Jan;
Amplification of the ferritin H gene in human breast cancer.
Torti SV 1997 Jan;
Cytotoxicity of gallium nitrate and transferrin-gallium following intravesical delivery in a bladder cancer model.
Torti SV 1997 Jan;
Tumor cell cytotoxicity of a novel metal chelator
Torti SV 1997 Jan;
Fer-1: an enhancer of the mouse ferritin H gene and target of E1A-mediated transcriptional repression.
Torti SV 1995 Jan;
Role of the transcription factor NFKB in the regulation of ferritin H by tumor necrosis factor-a.
Torti SV 1995 Jan;
Cytokine regulation of ferritin expression.
Torti SV 1993 Jan;
Selective repression of the H subunit of ferritin by adenovirus E1A.
Torti SV 1993 Jan;
A functional murine ferritin heavy chain gene.
Torti SV 1991 Jan;
Tumor necrosis factor alpha: an ironindependent regulator of ferritin H?
Torti SV 1989 Jan;
Isolation of a temperature-sensitive lipoprotein mutant of Escherichia coli.
Torti SV 1976 Jan;

Editorials

CD63 orchestrates ferritin export.
Torti, Suzy V; Torti, Frank M Blood 2021 Oct;138(16):1387-1389

Reviews

Mass spectrometry imaging of metals in tissues and cells: Methods and biological applications.
Gorman, Brittney L; Torti, Suzy V; Torti, Frank M; Anderton, Christopher R Biochimica et biophysica acta. General subjects 2023 Feb;130329
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Stockwell, Brent R; Friedmann Angeli, José Pedro; Bayir, Hülya; Bush, Ashley I; Conrad, Marcus; Dixon, Scott J; Fulda, Simone; Gascón, Sergio; Hatzios, Stavroula K; Kagan, Valerian E; Noel, Kay; Jiang, Xuejun; Linkermann, Andreas; Murphy, Maureen E; Overholtzer, Michael; Oyagi, Atsushi; Pagnussat, Gabriela C; Park, Jason; Ran, Qitao; Rosenfeld, Craig S; Salnikow, Konstantin; Tang, Daolin; Torti, Frank M; Torti, Suzy V; Toyokuni, Shinya; Woerpel, K A; Zhang, Donna D Cell 2017 Oct;171(2):273-285

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
Intracellular and extracellular glutathione levels modulate the sensitivity of breast cancer cells to silver nanoparticles	Poster	AACR Special Conference on Nano in Cancer: Linking Chemistry, Biology,and Clinical Applications in V	2011	Miami, FL
Surface functionalization and surfactant coating mediate the thrombogenicfty of carbon nanotubes	Poster	AACR Special Conference on Nano in Cancer	2011	Miami, FL
Development of multiwalled carbon nanotubes for cancer therapy.	Talk	11th International Conference on the Science and Applications of nanotubes	2010	Montreal, Canada
Effects of the HK5-Ferritin Interaction and Iron on Tumor Angiogenesis.	Poster	Proc. Am. Assoc. CA Res.	2010
Rational Development of a NIR-Resonant Nanomaterial for the Thermal Treatment of Cancer.	Poster	Materials Research Society Spring Conference	2010	San Francisco, CA
Magnetic Resonance Temperature Imaging Guided Laser-Induced Thermal Therapy with Multi-Walled Carbon Nanotubes.	Poster	American Association of Physicists in Medicine (AAPM) 51th Annual meeting	2009	Anaheim, CA
Roles of surface functionalization and surfactant coating in the initiation of blood clotting by multiwalled carbon nanotubes.	Poster	American Society for Nanomedicine Annual Conference	2009	Potomac, MD
Novel AccQ-Tag UPLC/MS method for high-throughput analysis of amino acids and glutathione in normal and HME-transformed human mammary epithelial cells.	Poster	57th ASMS Conference on Mass Spectrometry	2009
Feasibility study for applying irreversible electroporation to the treatment of breast cancer.	Poster	Proc. ASME Summer Bioengineering Conference	2009
Intersections between iron and cancer	Talk	Brigham Young University	2009	Provo, Utah
Multiwalled nanotubes in the treatment of kidney tumors	Talk	NanoConference at Wake Forest University	2009	Wake Forest University
Cytoprotective effect of ferritin following oxidative stress in renal ischemia-reperfusioin injury.	Poster	Soc. Free Rad. Bio. & Med.	2008
Ferritin inhibits the anti-angiogenic effects of HKa.	Poster	American Association for Cancer Research Annual Meeting	2008	San Diego, CA
The human bone morphogenetic protein antagonist BARC is downregulated in renal cancers.	Poster	Proc. Am. Assoc. CA Res.	2007
Ferritin inhibits cleavage of high molecular weight kininogen by elastase and mast cell tryptase.	Poster	Association of American Physicians Annual Meeting	2006	Chicago, IL
BARC: A Novel, Human BMP Antagonist Downregulated in Breast and Renal Cancers.	Poster	ASClIAAP Joint Meeting	2006	The Fairmont Hotel, Chicago, Illinois
Oxidative stress and acute toxicity caused by the alkylatlng carcinogen azoxymethane in rte liver are inhibited by the coffee diterpenes kahweol and cafestol.	Poster	Proc. Am. Assoc. CA Res	2006
Tachpyridine, a metal chelator, induces cell cycle checkpoints	Talk	International Conference on Bioiron	2005	Prague, Czech Republic
Parameters of iron metabolism in a model of breast cancer progression.	Poster	Proc. Am. Assoc. CA Res	2005
Ferritin and iron chelation in vitro and in vivo	Talk	Workshop on Biolron in Thallassemia, Sickle Cell Disease, and Hemochromatosis	2004	Bodega Bay, California
Ferritin H regulatin by YB-1 in human mammary epithelial cells.	Poster	Proc. Am. Assoc. CA Res	2004
Chemopreventive agents and xenobiotics activate the murine ferritin H gene via a Nrf2 dependent mechanism	Talk	International Conference on Bioiron	2003	Washington D.C.
Quantification of Tachpyridine and its metal complex metabolites in cells and tissue culture media by high-performance liquid chromatography.	Poster	Proc. Am. Assoc. CA Res	2003
Tachpyridine, a novel iron chelator, induces G2/M cell-cycle arrest and functions as a radiosensitizer in p53+1+ and p53 -1- isogenic cell lines.	Poster	Proc. Am. Assoc. CA Res.	2003
Pharmacokinetics of tachpyr (NSC-709598) in rats.	Poster	Proc. Am. Assoc. CA Res.	2003
Single cell analysis of the role of mitochondrial pathways in apoptosis induced by tachpyridine, an anti-cancer iron chelator.	Poster	Proc. Amer. Assoc. Cancer Res.	2002
Oxathiolene oxides activate cytoprotective enzymes by an aromatic hydrocarbon independent mechanism.	Poster	Proc. Amer. Assoc. Cancer Res.	2002
Optimimzing Tach family chelators	Talk	National Cancer Institute	2002
Apoptosis by tachpyridine, a novel iron chelator and potential anti-cancer agent, involves caspase activation.	Poster	Proc. Amer. Assoc. Cancer Res.	2001
Effect of c-fos genotype and oltipraz treatment on phase II protein expression in mice.	Poster	Proc. Amer. Assoc. Cancer Res	2001
Tachpyridine, a potential anti-cancer agent in the treatment of tumors with mutated p53.	Poster	NIGMS Metals in Medicine Meeting	2000
Adenovirus E1A blocks oxidant-dependent ferritin induction and sensitizes cells to pro-oxidants	Talk	FASEB	2000	San Diego
Tach pyridine: preclinical development	Talk	National Cancer Institute	2000
Iron Chelation in Cancer Therapy. Plenary Speaker)	Talk	World Congress on Iron Metabolism	1999	Sorrento, Italy
Tach pyridine: Potential as an anti-tumor therapeutic	Talk	National Cancer Institute	1998
The ferritin H gene is amplified in human breast cancers carrying an 11q13 amplification as demonstrated by fluorescence in situ hybridization.	Poster	Proc. Amer. Soc. Clin. Oncol	1997
In vivo formation of interspecies ferritin heteropolymers: evolutionary conservation of function	Talk	International Conference on Bioiron	1995	Asheville, N.C.
Repression of ferritin H by adenovirus EIA oncogene	Talk	11th International Conference in Iron and Iron Proteins	1993	Jerusalem, Israel

Title or Abstract

Type

Sponsor/Event

Date/Year

Location

Intracellular and extracellular glutathione levels modulate the sensitivity of breast cancer cells to silver nanoparticles

Poster

AACR Special Conference on Nano in Cancer: Linking Chemistry, Biology,and Clinical Applications in V

2011

Miami, FL

Surface functionalization and surfactant coating mediate the thrombogenicfty of carbon nanotubes

Poster

AACR Special Conference on Nano in Cancer

2011

Miami, FL

Development of multiwalled carbon nanotubes for cancer therapy.

Talk

11th International Conference on the Science and Applications of nanotubes

2010

Montreal, Canada

Effects of the HK5-Ferritin Interaction and Iron on Tumor Angiogenesis.

Poster

Proc. Am. Assoc. CA Res.

2010

Rational Development of a NIR-Resonant Nanomaterial for the Thermal Treatment of Cancer.

Poster

Materials Research Society Spring Conference

2010

San Francisco, CA

Magnetic Resonance Temperature Imaging Guided Laser-Induced Thermal Therapy with Multi-Walled Carbon Nanotubes.

Poster

American Association of Physicists in Medicine (AAPM) 51th Annual meeting

2009

Anaheim, CA

Roles of surface functionalization and surfactant coating in the initiation of blood clotting by multiwalled carbon nanotubes.

Poster

American Society for Nanomedicine Annual Conference

2009

Potomac, MD

Novel AccQ-Tag UPLC/MS method for high-throughput analysis of amino acids and glutathione in normal and HME-transformed human mammary epithelial cells.

Poster

57th ASMS Conference on Mass Spectrometry

2009

Feasibility study for applying irreversible electroporation to the treatment of breast cancer.

Poster

Proc. ASME Summer Bioengineering Conference

2009

Intersections between iron and cancer

Talk

Brigham Young University

2009

Provo, Utah

Multiwalled nanotubes in the treatment of kidney tumors

Talk

NanoConference at Wake Forest University

2009

Wake Forest University

Cytoprotective effect of ferritin following oxidative stress in renal ischemia-reperfusioin injury.

Poster

Soc. Free Rad. Bio. & Med.

2008

Ferritin inhibits the anti-angiogenic effects of HKa.

Poster

American Association for Cancer Research Annual Meeting

2008

San Diego, CA

The human bone morphogenetic protein antagonist BARC is downregulated in renal cancers.

Poster

Proc. Am. Assoc. CA Res.

2007

Ferritin inhibits cleavage of high molecular weight kininogen by elastase and mast cell tryptase.

Poster

Association of American Physicians Annual Meeting

2006

Chicago, IL

BARC: A Novel, Human BMP Antagonist Downregulated in Breast and Renal Cancers.

Poster

ASClIAAP Joint Meeting

2006

The Fairmont Hotel, Chicago, Illinois

Oxidative stress and acute toxicity caused by the alkylatlng carcinogen azoxymethane in rte liver are inhibited by the coffee diterpenes kahweol and cafestol.

Poster

Proc. Am. Assoc. CA Res

2006

Tachpyridine, a metal chelator, induces cell cycle checkpoints

Talk

International Conference on Bioiron

2005

Prague, Czech Republic

Parameters of iron metabolism in a model of breast cancer progression.

Poster

Proc. Am. Assoc. CA Res

2005

Ferritin and iron chelation in vitro and in vivo

Talk

Workshop on Biolron in Thallassemia, Sickle Cell Disease, and Hemochromatosis

2004

Bodega Bay, California

Ferritin H regulatin by YB-1 in human mammary epithelial cells.

Poster

Proc. Am. Assoc. CA Res

2004

Chemopreventive agents and xenobiotics activate the murine ferritin H gene via a Nrf2 dependent mechanism

Talk

International Conference on Bioiron

2003

Washington D.C.

Quantification of Tachpyridine and its metal complex metabolites in cells and tissue culture media by high-performance liquid chromatography.

Poster

Proc. Am. Assoc. CA Res

2003

Tachpyridine, a novel iron chelator, induces G2/M cell-cycle arrest and functions as a radiosensitizer in p53+1+ and p53 -1- isogenic cell lines.

Poster

Proc. Am. Assoc. CA Res.

2003

Pharmacokinetics of tachpyr (NSC-709598) in rats.

Poster

Proc. Am. Assoc. CA Res.

2003

Single cell analysis of the role of mitochondrial pathways in apoptosis induced by tachpyridine, an anti-cancer iron chelator.

Poster

Proc. Amer. Assoc. Cancer Res.

2002

Oxathiolene oxides activate cytoprotective enzymes by an aromatic hydrocarbon independent mechanism.

Poster

Proc. Amer. Assoc. Cancer Res.

2002

Optimimzing Tach family chelators

Talk

National Cancer Institute

2002

Apoptosis by tachpyridine, a novel iron chelator and potential anti-cancer agent, involves caspase activation.

Poster

Proc. Amer. Assoc. Cancer Res.

2001

Effect of c-fos genotype and oltipraz treatment on phase II protein expression in mice.

Poster

Proc. Amer. Assoc. Cancer Res

2001

Tachpyridine, a potential anti-cancer agent in the treatment of tumors with mutated p53.

Poster

NIGMS Metals in Medicine Meeting

2000

Adenovirus E1A blocks oxidant-dependent ferritin induction and sensitizes cells to pro-oxidants

Talk

FASEB

2000

San Diego

Tach pyridine: preclinical development

Talk

National Cancer Institute

2000

Iron Chelation in Cancer Therapy. Plenary Speaker)

Talk

World Congress on Iron Metabolism

1999

Sorrento, Italy

Tach pyridine: Potential as an anti-tumor therapeutic

Talk

National Cancer Institute

1998

The ferritin H gene is amplified in human breast cancers carrying an 11q13 amplification as demonstrated by fluorescence in situ hybridization.

Poster

Proc. Amer. Soc. Clin. Oncol

1997

In vivo formation of interspecies ferritin heteropolymers: evolutionary conservation of function

Talk

International Conference on Bioiron

1995

Asheville, N.C.

Repression of ferritin H by adenovirus EIA oncogene

Talk

11th International Conference in Iron and Iron Proteins

1993

Jerusalem, Israel