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Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity.
Greatorex, Spencer; Kaur, Supreet; Xirouchaki, Chrysovalantou E; Goh, Pei K; Wiede, Florian; Genders, Amanda J; Tran, Melanie; Jia, YaoYao; Raajendiran, Arthe; Brown, Wendy A; McLean, Catriona A; Sadoshima, Junichi; Watt, Matthew J; Tiganis, Tony Journal of Clinical Investigation 2023 Dec;134(3):e162533
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Jumonji domain-containing protein-3 (JMJD3) promotes myeloid fibroblast activation and macrophage polarization in kidney fibrosis.
An, Changlong; Jiao, Baihai; Du, Hao; Tran, Melanie; Song, Bo; Wang, Penghua; Zhou, Dong; Wang, Yanlin British Journal of Pharmacology 2023 Apr;180(17):2250-2265
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SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice.
Tran, Melanie; Mostofa, Golam; Picard, Michael; Wu, Jianguo; Wang, Li; Shin, Dong-Ju Journal of Endocrinology 2023 Mar;256(3):e220073
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Pharmacological Inhibition of S100A4 Attenuates Fibroblast Activation and Renal Fibrosis.
Wen, Jia; Jiao, Baihai; Tran, Melanie; Wang, Yanlin Cells 2022 Sep;11(17):2762
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MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease.
Mostofa, Md Golam; Tran, Melanie; Gilling, Shaynian; Lee, Grace; Fraher, Ondine; Jin, Lei; Kang, Hyunju; Park, Young-Ki; Lee, Ji-Young; Wang, Li; Shin, Dong-Ju Journal of Biological Chemistry 2022 Jun;298(6):101966
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Phosphoinositide 3 Kinase γ Plays a Critical Role in Acute Kidney Injury.
Jin, Xiaogao; Chu, Qinjun; Sun, Liwei; Tran, Melanie; Wang, Yanlin Cells 2022 Feb;11(5):772
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Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance.
Xirouchaki, Chrysovalantou E; Jia, Yaoyao; McGrath, Meagan J; Greatorex, Spencer; Tran, Melanie; Merry, Troy L; Hong, Dawn; Eramo, Matthew J; Broome, Sophie C; Woodhead, Jonathan S T; D'souza, Randall F; Gallagher, Jenny; Salimova, Ekaterina; Huang, Cheng; Schittenhelm, Ralf B; Sadoshima, Junichi; Watt, Matthew J; Mitchell, Christina A; Tiganis, Tony Science advances 2021 Dec;7(51):eabl4988
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MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis.
Song, Yongfeng; Tran, Melanie; Wang, Li; Shin, Dong-Ju; Wu, Jianguo Laboratory investigation 2021 Dec;
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STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy.
Jiao, Baihai; An, Changlong; Du, Hao; Tran, Melanie; Wang, Penghua; Zhou, Dong; Wang, Yanlin Cells 2021 Nov;10(11):
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Myeloid PTEN deficiency aggravates renal inflammation and fibrosis in angiotensin II-induced hypertension.
An, Changlong; Jiao, Baihai; Du, Hao; Tran, Melanie; Zhou, Dong; Wang, Yanlin Journal of cellular physiology 2021 Sep;
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A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity.
Tran, Melanie; Wu, Jianguo; Wang, Li; Shin, Dong-Ju Molecular pharmacology 2021 Apr;99(4):277-285
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Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis.
Jiao, Baihai; An, Changlong; Tran, Melanie; Du, Hao; Wang, Penghua; Zhou, Dong; Wang, Yanlin Frontiers in immunology 2021 Jan;12735014
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PDK4-Deficiency Reprograms Intrahepatic Glucose and Lipid Metabolism to Facilitate Liver Regeneration in Mice.
Zhao, Yulan; Tran, Melanie; Wang, Li; Shin, Dong-Ju; Wu, Jianguo Hepatology communications 2020 Apr;4(4):504-517
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Long noncoding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis.
Liu, Chune; Yang, Zhihong; Wu, Jianguo; Zhang, Li; Lee, Sangmin; Shin, Dong-Ju; Tran, Melanie; Wang, Li Hepatology (Baltimore, Md.) 2018 May;67(5):1768-1783
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Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH.
Tran, Melanie; Lee, Sang-Min; Shin, Dong-Ju; Wang, Li JCI insight 2017 Nov;2(21):
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Maternal growth restriction and stress exposure in rats differentially alters expression of components of the placental glucocorticoid barrier and nutrient transporters.
Briffa, Jessica F; Hosseini, Sogand S; Tran, Melanie; Moritz, Karen M; Cuffe, James S M; Wlodek, Mary E Placenta 2017 Nov;5930-38
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Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.
Merry, Troy L; Tran, Melanie; Dodd, Garron T; Mangiafico, Salvatore P; Wiede, Florian; Kaur, Supreet; McLean, Catriona L; Andrikopoulos, Sofianos; Tiganis, Tony Diabetologia 2016 Dec;59(12):2632-2644
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Metabolomics Analysis Revealed Distinct Cyclic Changes of Metabolites Altered by Chronic Ethanol-Plus-Binge and Shp Deficiency.
Tran, Melanie; Yang, Zhihong; Liangpunsakul, Suthat; Wang, Li Alcoholism, clinical and experimental research 2016 Dec;40(12):2548-2556
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Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats.
Tran, Melanie; Young, Margaret E; Jefferies, Andrew J; Hryciw, Deanne H; Ward, Michelle M; Fletcher, Erica L; Wlodek, Mary E; Wadley, Glenn D Physiological reports 2015 Sep;3(9):
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Pregnant growth restricted female rats have bone gains during late gestation which contributes to second generation adolescent and adult offspring having normal bone health.
Anevska, Kristina; Gallo, Linda A; Tran, Melanie; Jefferies, Andrew J; Wark, John D; Wlodek, Mary E; Romano, Tania Bone 2015 May;74199-207
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Transgenerational left ventricular hypertrophy and hypertension in offspring after uteroplacental insufficiency in male rats.
Master, Jordanna S; Zimanyi, Monika A; Yin, Kom V; Moritz, Karen M; Gallo, Linda A; Tran, Melanie; Wlodek, Mary E; Black, Mary J Clinical and experimental pharmacology & physiology 2014 Nov;41(11):884-90
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Transgenerational programming of fetal nephron deficits and sex-specific adult hypertension in rats.
Gallo, Linda A; Tran, Melanie; Cullen-McEwen, Luise A; Denton, Kate M; Jefferies, Andrew J; Moritz, Karen M; Wlodek, Mary E Reproduction, fertility, and development 2014 Aug;26(7):1032-43
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Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.
Gurzov, Esteban N; Tran, Melanie; Fernandez-Rojo, Manuel A; Merry, Troy L; Zhang, Xinmei; Xu, Yang; Fukushima, Atsushi; Waters, Michael J; Watt, Matthew J; Andrikopoulos, Sofianos; Neel, Benjamin G; Tiganis, Tony Cell metabolism 2014 Jul;20(1):85-102
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High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage.
Merry, Troy L; Tran, Melanie; Stathopoulos, Maria; Wiede, Florian; Fam, Barbara Christianne; Dodd, Garron T; Clarke, Iain; Watt, Matthew J; Andrikopoulos, Sofianos; Tiganis, Tony Antioxidants & redox signaling 2014 May;20(14):2114-29
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Embryo transfer cannot delineate between the maternal pregnancy environment and germ line effects in the transgenerational transmission of disease in rats.
Tran, Melanie; Gallo, Linda A; Hanvey, Alanna N; Jefferies, Andrew J; Westcott, Kerryn T; Cullen-McEwen, Luise A; Gardner, David K; Moritz, Karen M; Wlodek, Mary E American journal of physiology. Regulatory, integrative and comparative physiology 2014 Apr;306(8):R607-18
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Transgenerational metabolic outcomes associated with uteroplacental insufficiency.
Tran, Melanie; Gallo, Linda A; Jefferies, Andrew J; Moritz, Karen M; Wlodek, Mary E The Journal of endocrinology 2013 Apr;217(1):105-18
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Pregnancy in aged rats that were born small: cardiorenal and metabolic adaptations and second-generation fetal growth.
Gallo, Linda A; Tran, Melanie; Moritz, Karen M; Jefferies, Andrew J; Wlodek, Mary E FASEB journal 2012 Oct;26(10):4337-47
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Long-term alteration in maternal blood pressure and renal function after pregnancy in normal and growth-restricted rats.
Gallo, Linda A; Denton, Kate M; Moritz, Karen M; Tare, Marianne; Parkington, Helena C; Davies, Meagan; Tran, Melanie; Jefferies, Andrew J; Wlodek, Mary E Hypertension 2012 Jul;60(1):206-13
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Cardio-renal and metabolic adaptations during pregnancy in female rats born small: implications for maternal health and second generation fetal growth.
Gallo, Linda A; Tran, Melanie; Moritz, Karen M; Mazzuca, Marc Q; Parry, Laura J; Westcott, Kerryn T; Jefferies, Andrew J; Cullen-McEwen, Luise A; Wlodek, Mary E The Journal of physiology 2012 Feb;590(3):617-30
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Effect of pregnancy for females born small on later life metabolic disease risk.
Tran, Melanie; Gallo, Linda A; Wadley, Glenn D; Jefferies, Andrew J; Moritz, Karen M; Wlodek, Mary E PloS one 2012 Jan;7(9):e45188
