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Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.
Ravichandran, Sathyabaarathi; Erra-Diaz, Fernando; Karakaslar, Onur E; Marches, Radu; Kenyon-Pesce, Lisa; Rossi, Robert; Chaussabel, Damien; Nehar-Belaid, Djamel; LaFon, David C; Pascual, Virginia; Palucka, Karolina; Paust, Silke; Nahm, Moon H; Kuchel, George A; Banchereau, Jacques; Ucar, Duygu. Nature Immunology. 2024 Jan;
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Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.
Cheong, Jin-Gyu; Ravishankar, Arjun; Sharma, Siddhartha; Parkhurst, Christopher N; Grassmann, Simon A; Wingert, Claire K; Laurent, Paoline; Ma, Sai; Paddock, Lucinda; Miranda, Isabella C; Karakaslar, Emin Onur; Nehar-Belaid, Djamel; Thibodeau, Asa; Bale, Michael J; Kartha, Vinay K; Yee, Jim K; Mays, Minh Y; Jiang, Chenyang; Daman, Andrew W; Martinez de Paz, Alexia; Ahimovic, Dughan; Ramos, Victor; Lercher, Alexander; Nielsen, Erik; Alvarez-Mulett, Sergio; Zheng, Ling; Earl, Andrew; Yallowitz, Alisha; Robbins, Lexi; LaFond, Elyse; Weidman, Karissa L; Racine-Brzostek, Sabrina; Yang, He S; Price, David R; Leyre, Louise; Rendeiro, André F; Ravichandran, Hiranmayi; Kim, Junbum; Borczuk, Alain C; Rice, Charles M; Jones, R Brad; Schenck, Edward J; Kaner, Robert J; Chadburn, Amy; Zhao, Zhen; Pascual, Virginia; Elemento, Olivier; Schwartz, Robert E; Buenrostro, Jason D; Niec, Rachel E; Barrat, Franck J; Lief, Lindsay; Sun, Joseph C; Ucar, Duygu; Josefowicz, Steven Z Cell 2023 Aug;186(18):3882-3902.e24
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Challenges and opportunities for modeling aging and cancer.
Anczuków, Olga; Airhart, Susie; Chuang, Jeffrey H; Coussens, Lisa M; Kuchel, George A; Korstanje, Ron; Li, Sheng; Lucido, Anna Lisa; McAllister, Sandra S; Politi, Katerina; Polyak, Kornelia; Ratliff, Timothy; Ren, Gary; Trowbridge, Jennifer J; Ucar, Duygu; Palucka, Karolina. Cancer Cell. 2023 Apr;
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Concomitant inhibition of PPARγ and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells.
Erra Diaz, Fernando; Mazzitelli, Ignacio; Bleichmar, Lucía; Melucci, Claudia; Thibodeau, Asa; Dalotto Moreno, Tomás; Marches, Radu; Rabinovich, Gabriel A; Ucar, Duygu; Geffner, Jorge Cell reports 2023 Mar;42(3):112156
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Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging.
Karakaslar, Emin Onur; Katiyar, Neerja; Hasham, Muneer; Youn, Ahrim; Sharma, Siddhartha; Chung, Cheng-Han; Marches, Radu; Korstanje, Ron; Banchereau, Jacques; Ucar, Duygu Aging cell 2023 Feb;e13792
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CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq data.
Thibodeau, Asa; Khetan, Shubham; Eroglu, Alper; Tewhey, Ryan; Stitzel, Michael L; Ucar, Duygu PLoS computational biology 2021 Dec;17(12):e1009670
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AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data.
Thibodeau, Asa; Eroglu, Alper; McGinnis, Christopher S; Lawlor, Nathan; Nehar-Belaid, Djamel; Kursawe, Romy; Marches, Radu; Conrad, Daniel N; Kuchel, George A; Gartner, Zev J; Banchereau, Jacques; Stitzel, Michael L; Cicek, A Ercument; Ucar, Duygu Genome Biology 2021 Sep;22(1):252
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Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28.
Lawlor, Nathan; Nehar-Belaid, Djamel; Grassmann, Jessica D S; Stoeckius, Marlon; Smibert, Peter; Stitzel, Michael L; Pascual, Virginia; Banchereau, Jacques; Williams, Adam; Ucar, Duygu Frontiers in immunology 2021 Jan;12636720
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Sestrins induce natural killer function in senescent-like CD8+ T cells.
Pereira, Branca I; De Maeyer, Roel P H; Covre, Luciana P; Nehar-Belaid, Djamel; Lanna, Alessio; Ward, Sophie; Marches, Radu; Chambers, Emma S; Gomes, Daniel C O; Riddell, Natalie E; Maini, Mala K; Teixeira, Vitor H; Janes, Samuel M; Gilroy, Derek W; Larbi, Anis; Mabbott, Neil A; Ucar, Duygu; Kuchel, George A; Henson, Sian M; Strid, Jessica; Lee, Jun H; Banchereau, Jacques; Akbar, Arne N Nature Immunology. 2020 Mar;
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V-SVA: an R Shiny application for detecting and annotating hidden sources of variation in single cell RNA-seq data.
Lawlor, Nathan; Marquez, Eladio J; Lee, Donghyung; Ucar, Duygu Bioinformatics (Oxford, England) 2020 Mar;
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Sexual-dimorphism in human immune system aging.
Márquez, Eladio J; Chung, Cheng-Han; Marches, Radu; Rossi, Robert J; Nehar-Belaid, Djamel; Eroglu, Alper; Mellert, David J; Kuchel, George A; Banchereau, Jacques; Ucar, Duygu Nature Communications. 2020 Feb;11(1):751
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The lethal sex gap: COVID-19.
Márquez, Eladio J; Trowbridge, Jennifer; Kuchel, George A; Banchereau, Jacques; Ucar, Duygu Immunity & ageing : I & A 2020 Jan;1713
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Cell Specificity of Human Regulatory Annotations and Their Genetic Effects on Gene Expression.
Varshney, Arushi; VanRenterghem, Hadley; Orchard, Peter; Boyle, Alan P; Stitzel, Michael L; Ucar, Duygu; Parker, Stephen C J Genetics 2019 Feb;211(2):549-562
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Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function.
Lawlor, Nathan; Márquez, Eladio J; Orchard, Peter; Narisu, Narisu; Shamim, Muhammad Saad; Thibodeau, Asa; Varshney, Arushi; Kursawe, Romy; Erdos, Michael R; Kanke, Matt; Gu, Huiya; Pak, Evgenia; Dutra, Amalia; Russell, Sheikh; Li, Xingwang; Piecuch, Emaly; Luo, Oscar; Chines, Peter S; Fuchbserger, Christian; NIH Intramural Sequencing Center; Sethupathy, Praveen; Aiden, Aviva Presser; Ruan, Yijun; Aiden, Erez Lieberman; Collins, Francis S; Ucar, Duygu; Parker, Stephen C J; Stitzel, Michael L Cell reports 2019 Jan;26(3):788-801.e6
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A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate.
Caielli, Simone; Veiga, Diogo Troggian; Balasubramanian, Preetha; Athale, Shruti; Domic, Bojana; Murat, Elise; Banchereau, Romain; Xu, Zhaohui; Chandra, Manjari; Chung, Cheng-Han; Walters, Lynnette; Baisch, Jeanine; Wright, Tracey; Punaro, Marilynn; Nassi, Lorien; Stewart, Katie; Fuller, Julie; Ucar, Duygu; Ueno, Hideki; Zhou, Joseph; Banchereau, Jacques; Pascual, Virginia Nature medicine 2019 Jan;25(1):75-81
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Detection of correlated hidden factors from single cell transcriptomes using Iteratively Adjusted-SVA (IA-SVA).
Lee, Donghyung; Cheng, Anthony; Lawlor, Nathan; Bolisetty, Mohan; Ucar, Duygu Scientific reports 2018 Nov;8(1):17040
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BiFET: sequencing Bias-free transcription factor Footprint Enrichment Test.
Youn, Ahrim; Marquez, Eladio J; Lawlor, Nathan; Stitzel, Michael L; Ucar, Duygu Nucleic acids research 2018 Nov;
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A neural network based model effectively predicts enhancers from clinical ATAC-seq samples.
Thibodeau, Asa; Uyar, Asli; Khetan, Shubham; Stitzel, Michael L; Ucar, Duygu Scientific reports 2018 Oct;8(1):16048
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Type 2 Diabetes Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets.
Khetan, Shubham; Kursawe, Romy; Youn, Ahrim; Lawlor, Nathan; Jillette, Alexandria; Marquez, Eladio J; Ucar, Duygu; Stitzel, Michael L Diabetes 2018 Sep;672466-2477
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A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.
Kycia, Ina; Wolford, Brooke N; Huyghe, Jeroen R; Fuchsberger, Christian; Vadlamudi, Swarooparani; Kursawe, Romy; Welch, Ryan P; Albanus, Ricardo d'Oliveira; Uyar, Asli; Khetan, Shubham; Lawlor, Nathan; Bolisetty, Mohan; Mathur, Anubhuti; Kuusisto, Johanna; Laakso, Markku; Ucar, Duygu; Mohlke, Karen L; Boehnke, Michael; Collins, Francis S; Parker, Stephen C J; Stitzel, Michael L American journal of human genetics 2018 Apr;102(4):620-635
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I-ATAC: interactive pipeline for the management and pre-processing of ATAC-seq samples.
Ahmed, Zeeshan; Ucar, Duygu PeerJ 2017 Nov;5e4040
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Chromatin interaction networks revealed unique connectivity patterns of broad H3K4me3 domains and super enhancers in 3D chromatin.
Thibodeau, Asa; Márquez, Eladio J; Shin, Dong-Guk; Vera-Licona, Paola; Ucar, Duygu Scientific reports 2017 Oct;7(1):14466
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Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts.
Lawlor, Nathan; Youn, Ahrim; Kursawe, Romy; Ucar, Duygu; Stitzel, Michael L Scientific reports 2017 Sep;7(1):11959
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The chromatin accessibility signature of human immune aging stems from CD8(+) T cells.
Ucar, Duygu; Márquez, Eladio J; Chung, Cheng-Han; Marches, Radu; Rossi, Robert J; Uyar, Asli; Wu, Te-Chia; George, Joshy; Stitzel, Michael L; Palucka, A Karolina; Kuchel, George A; Banchereau, Jacques The Journal of experimental medicine 2017 Sep;2143123-3144
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QuIN: A Web Server for Querying and Visualizing Chromatin Interaction Networks.
Thibodeau, Asa; Márquez, Eladio J; Luo, Oscar; Ruan, Yijun; Menghi, Francesca; Shin, Dong-Guk; Stitzel, Michael L; Vera-Licona, Paola; Ucar, Duygu PLoS computational biology 2016 Jun;12(6):e1004809
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The tandem duplicator phenotype as a distinct genomic configuration in cancer.
Menghi, Francesca; Inaki, Koichiro; Woo, XingYi; Kumar, Pooja A; Grzeda, Krzysztof R; Malhotra, Ankit; Yadav, Vinod; Kim, Hyunsoo; Marquez, Eladio J; Ucar, Duygu; Shreckengast, Phung T; Wagner, Joel P; MacIntyre, George; Murthy Karuturi, Krishna R; Scully, Ralph; Keck, James; Chuang, Jeffrey H; Liu, Edison T Proceedings of the National Academy of Sciences of the United States of America 2016 Apr;113(17):E2373-82
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Computational inference of a genomic pluripotency signature in human and mouse stem cells.
Kurum, Esra; Benayoun, Bérénice A; Malhotra, Ankit; George, Joshy; Ucar, Duygu Biology direct 2016 Jan;1147
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Computational inference of H3K4me3 and H3K27ac domain length.
Zubek, Julian; Stitzel, Michael L; Ucar, Duygu; Plewczynski, Dariusz M PeerJ 2016 Jan;4e1750
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Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.
George, Joshy; Uyar, Asli; Young, Kira; Kuffler, Lauren; Waldron-Francis, Kaiden; Marquez, Eladio; Ucar, Duygu; Trowbridge, Jennifer J Nature communications 2016 Jan;712166
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Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function.
Stitzel, Michael L; Kycia, Ina; Kursawe, Romy; Ucar, Duygu Current diabetes reports 2015 Sep;15(9):66
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Cell-specific gene promoters are marked by broader spans of H3K4me3 and are associated with robust gene expression patterns.
Ucar, Duygu; Bayarsaihan, Dashzeveg Epigenomics 2015 Apr;7(2):129-31
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Developmental enhancers are marked independently of zygotic Nodal signals in Xenopus.
Gupta, Rakhi; Wills, Andrea; Ucar, Duygu; Baker, Julie Developmental biology 2014 Nov;395(1):38-49
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H3K4me3 breadth is linked to cell identity and transcriptional consistency.
Benayoun, Bérénice A; Pollina, Elizabeth A; Ucar, Duygu; Mahmoudi, Salah; Karra, Kalpana; Wong, Edith D; Devarajan, Keerthana; Daugherty, Aaron C; Kundaje, Anshul B; Mancini, Elena; Hitz, Benjamin C; Gupta, Rakhi; Rando, Thomas A; Baker, Julie C; Snyder, Michael P; Cherry, J Michael; Brunet, Anne Cell 2014 Jul;158(3):673-88
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FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis.
Webb, Ashley E; Pollina, Elizabeth A; Vierbuchen, Thomas; Urbán, Noelia; Ucar, Duygu; Leeman, Dena S; Martynoga, Ben; Sewak, Madhavi; Rando, Thomas A; Guillemot, François; Wernig, Marius; Brunet, Anne Cell reports 2013 Aug;4(3):477-91
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Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.
Rafalski, Victoria A; Ho, Peggy P; Brett, Jamie O; Ucar, Duygu; Dugas, Jason C; Pollina, Elizabeth A; Chow, Lionel M L; Ibrahim, Adiljan; Baker, Suzanne J; Barres, Ben A; Steinman, Lawrence; Brunet, Anne Nature cell biology 2013 Jun;15(6):614-24
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FoxO6 regulates memory consolidation and synaptic function.
Salih, Dervis A M; Rashid, Asim J; Colas, Damien; de la Torre-Ubieta, Luis; Zhu, Ruo P; Morgan, Alexander A; Santo, Evan E; Ucar, Duygu; Devarajan, Keerthana; Cole, Christina J; Madison, Daniel V; Shamloo, Mehrdad; Butte, Atul J; Bonni, Azad; Josselyn, Sheena A; Brunet, Anne Genes & development 2012 Dec;26(24):2780-801
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Combinatorial chromatin modification patterns in the human genome revealed by subspace clustering.
Ucar, Duygu; Hu, Qingyang; Tan, Kai Nucleic acids research 2011 May;39(10):4063-75
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An ensemble framework for clustering protein-protein interaction networks.
Asur, Sitaram; Ucar, Duygu; Parthasarathy, Srinivasan Bioinformatics (Oxford, England) 2007 Jul;23(13):i29-40
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A spatio-temporal mining approach towards summarizing and analyzing protein folding trajectories.
Yang, Hui; Parthasarathy, Srinivasan; Ucar, Duygu Algorithms for molecular biology : AMB 2007 Jan;23
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An Event-based Framework for Characterizing the Evolutionary Behavior of Interaction Graphs
Sitaram Asur, Srinivasan Parthasarathy, and Duygu Ucar ACM Transactions on Knowledge Discovery from Data (TKDD), 2009 34
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Construction of a Reference Gene Association Network from Multiple Profiling Data: Application to HIV Data Analysis
Duygu Ucar, Isaac Neuhaus, Petra Ross-MacDonald, Charles Tilford, Srinivasan Parthasarathy, Nathan Siemers, and Rui-Ru Ji Bioinformatics, 2007 23(20):2716-2724
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Discovering Regulatory DNA Elements Using Chromatin Signatures and Artificial Neural Network
Hiram Firpi, Duygu Ucar, and Kai Tan Bioinformatics, 2010 26(13):1579-1586
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Pre- dicting functionality of protein-DNA interactions by integrating diverse evidence
Duygu Ucar, Andreas Beyer, Srinivasan Parthasarathy, and Christopher T. Workman Bioinformatics (ISMB’09 Proceedings), 2009 25(12):137-144
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Transgenerational Epigenetic Inheritance of Longevity in C. elegans
Eric L. Greer, Travis J. Maures, Duygu Ucar, Anna G. Hauswirth, Elena Mancini, Jana P. Lim, Berenice Benayoun, Yang Shi, and Anne Brunet Nature, 2011 479(7373):365-371