Rajkumar Verma, Ph.D.Assistant Professor
Dr. Verma is an assistant professor in the Department of Neuroscience and the Pat and Jim Calhoun Cardiology Center at the UConn Health in Farmington, CT since 2016. Rajkumar completed his Ph.D. work at Central Drug Research Institute, Lucknow, India and earned his doctoral degree in pharmacy/pharmacology from Birla Institute of Technology, Mesra, Ranchi, India.
|B.Pharm||HNB Garhwal University||Pharmaceutical Sciences|
|M.Pharm||Birla Institute of Technology||Pharmacology|
|Ph.D.||Birla Institute of Technology||Pharmacology|
|Name of Award/Honor||Awarding Organization|
|First prize winner of the 2018 Stroke Progress and Innovation award by American Heart Association (AHA)||American Heart Association|
|START PPOC award||Office of Vice President for Research, University of Connecticut|
|Career development award||American Heart Association|
|Atomwise Artificial Intelligence Molecular Screen (AIMS) award||Atomwise Inc San Francisco, CA 94105|
|Travel award, ISN Advanced School 2015, Fitzroy Island, Australia||International Society for Neurochemistry|
|Junior Investigators Travel Award, International stroke conference, 2015||American Heart Association|
|Outstanding presentation award, Neurosciences retreat||Dept of Neurosciences, UConn Health|
|Postdoctoral training grant||American Heart Association|
|Tokuji Ikenaka Prize ‘Gold Award’ for best poster presentation in 10th biennial meeting of Asia Pacific Society for Neurochemistry (APSN) Phuket, Thailand||International Society for Neurochemistry/ APSN chapter|
CNS and CVS Pharmacology to Pharm D students. Neurobiology of Disease
My lab investigates the cause-effect-relationships of stroke outcome. we focus on following three specific areas of stroke research.
Project 1: Stroke remains a leading cause of disability in the United States. Despite recent advances, interventions to reduce damage and enhance recovery after stroke are absent. In this project we will investigate a novel drug target “Purinergic receptor P2X4” for therapeutic exploitation in stroke. We will determine how the inhibition of P2X4R signaling influences these excessive immune during stroke using mice genetically engineered for global or selective deletion of P2X4R in total myeloid or infiltrating myeloid population and also by using pharmacological modulation. The overall goal of this project is to determine if modulation of P2X4R signaling in myeloid cells is a viable therapy for stroke, working towards our long-term goal of developing and identifying target-based therapies for stroke.
Project 2: Vascular dementia (VaD) is the second most common form of dementia after Alzheimer’s disease (AD). Although it is the most rapidly increasing disorder in the aging population, VaD remains under diagnosed, studied and treated. Among many potential clinical triggers, multi-embolic infarcts and cerebral hypoperfusion are major causes of VaD. Among many subtypes of VaD, multi-infarct dementia is the most prominent one which results from multiple lesion or infarcts in brain parenchyma. At the molecular level, VaD is characterized by key neuronal and dendro-synaptic changes resulting in dysfunction and cognitive deficits. Therefore, greater understanding of the pathophysiology at the molecular level is needed to identify novel vascular substrates of dementia. Our goal here is to identify key proteins involved in modification of brain pathology during progression of VaD.
Project 3: MicroRNAs (miRNAs) are short non-coding RNAs and have emerged as a powerful intervention tool for many diseases including stroke. They regulate a broad spectrum of biological pathways through fine-tuning of protein expression levels and altering gene expression levels. miRNA can concurrently target multiple effectors of pathways involved in stroke pathology. In this project we focus on the differential expression of miRNA expressed in mice after stroke and determine if blocking (with genetic deletion or antagomirs) or enhancing (mimics) these target miRNA modulates their effects. The overall goal our lab is to determine if manipulation of target miRNAs can improve functional recovery after stroke
Accepting Lab Rotation Students: Summer '19, Fall '19, Spring '20