Photo of Yanlin  Wang, M.D., Ph.D., FASN

Yanlin Wang, M.D., Ph.D., FASN

Professor of Medicine
Chief, Division of Nephrology
Academic Office Location:
Nephrology
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-2799
Website(s):

Nephrology

Cell Biology Graduate Program

Immunology Graduate Program

Education
DegreeInstitutionMajor
M.D.Weifang Medical UniversityMedicine
M.S.Fudan UniversityMedicine
Ph.D.The University of Texas Medical BranchPharmacology and Toxicology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralHarvard Medical School/Brigham and Women's HospitalCardiovascular Medicine
ResidencyTufts University/Carney HospitalInternal Medicine
FellowshipBaylor College of MedicineNephrology

Awards
Name of Award/HonorAwarding Organization
MERIT Review AwardU.S. Department of Veterans Affairs
Young Investigator AwardChinese American Society of Nephrology
America's Top Physicians - NephrologyConsumer's Research Council of America
National Scientist Development AwardAmerican Heart Association
Nephrology Fellowship AwardAMGEN
National Research Service AwardNational Institutes of Health
American Heart Association Trainee Abstract AwardAmerican Heart Association Council on Basic Cardiovascular Sciences
Jane Welsh Award for Excellence in Cardiovascular ResearchThe University of Texas Graduate School
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
MD/PhD Steering CommitteeEducation CommitteeMemberUConn HealthUniversity2019
NIH PBKD Study SectionStudy SectionReviewerExternalNational2019
AHA Fellowship Cardiorenal BSc CommitteeStudy SectionReviewerExternalNational2019
Frontiers in PhysiologyEditorial BoardReview EditorExternalInternational2019
Scientific ReportsEditorial BoardEditorial Board MemberExternalInternational2018
Research Strategic Plan CommitteeResearch CommitteeMemberUConn HealthUniversity2018
American Society of NephrologyProfessional/Scientific OrganizationFellowExternalNational2010

The overall goal of the Wang lab is to elucidate the cellular and molecular mechanisms underlying the pathogenesis of kidney disease with a focus on the roles of inflammatory cells and fibroblasts in the pathogenesis of kidney injury and fibrosis. We have demonstrated that that bone marrow-derived fibroblasts contribute significantly to the population of myofibroblasts resulting in kidney fibrosis. The presence and development of these fibroblasts from a CD45+ mononuclear precursors are driven by induction of chemokines and cytokines. Recently, we have been working on epigenetic regulation of inflammation and fibroblast activation, CXCL16/CXCR6/PI3K signaling pathway and cGAS-STING signaling pathway in regulation of macrophage activation and pathogenesis of kidney fibrosis.

Accepting Lab Rotation Students: Summer 2021, Fall 2021, and Spring 2022

Journal Articles

Abstracts

  • Gadolinium Deposition within the Brain 10 years After Undergoing Up to 26 Monthly Triple-Dose Gadopentetate Dimeglumine in Multiple Sclerosis Patients.
    DeBevits J, Bageac D, Wu R, DiCamillo P, Munbodh R, Hu C, Wang Y, Wang L, Karimeddini D, Dhib-Jalbut S, Wolansky L. ASNR Annual Meeting, May 18-23, 2019. Boston. 2019 May;
  • Hematologic abnormalities in patients exposed to monthly triple-dose gadolinium for a year.
    Bageac D, Hu C, Wu R, DeBevits J, DiCamillo P, Wang L, Munbodh R, Karimeddini D, Naismith R, Dhib-Jalbut S, Redko S, Cook S, Wang Y, Malchoff C, Wolansky L. American College of Radiology Annual Meeting. Washington, DC. 2019 May;

Editorials

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Targeting Fibrosis for Chronic Kidney DiseaseTalkYale University2019New Haven, CT
Molecular Mechanisms and Therapeutic Targets of FibrosisTalkUniversity of Rochester2017Rochester, NY
Fibrosis as a Therapeutic Target for Chronic Kidney DiseaseTalkUniversity of Minnesota2017Minneapolis, MN
Targeting Fibrosis for the Treatment of Chronic Kidney DiseaseTalkUniversity of New Mexico2017Albuquerque, NM
Targeting Fibrosis for Chronic Kidney DiseaseTalkUniversity of Louisville2017Louisville, KY
Molecular Mechanisms and Therapeutic Targets of FibrosisPlenary LectureNanfang International Forum – Research Advances in Kidney Disease2017Guangzhou, China
Novel Insights and Therapeutic Targets of Renal FibrosisTalkBrown University2016Providence, RI
The Role of Bone Marrow-derived Fibroblasts in Renal FibrosisTalkMount Sinai School of Medicine2015New York, NY