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Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8.
Zhang, Biyan; Chen, Shuting; Yin, Xiangyun; McBride, Caleb D; Gertie, Jake A; Yurieva, Marina; Bielecka, Agata A; Hoffmann, Brian; Travis Hinson, J; Grassmann, Jessica; Xu, Lan; Siniscalco, Emily R; Soldatenko, Arielle; Hoyt, Laura; Joseph, Julie; Norton, Elizabeth B; Uthaman, Gowthaman; Palm, Noah W; Liu, Elise; Eisenbarth, Stephanie C; Williams, Adam Mucosal immunology 2023 Dec;
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Transcriptomic responses in the blood and sputum of cigarette smokers compared to e-cigarette vapers.
Perez, Mario F; Yurieva, Marina; Poddutoori, Spandana; Mortensen, Eric M; Crotty Alexander, Laura E; Williams, Adam Respiratory research 2023 May;24(1):134
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Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro.
Uthaya Kumar, Dinesh Babu; Motakis, Efthymios; Yurieva, Marina; Kohar, Vivek; Martinek, Jan; Wu, Te-Chia; Khoury, Johad; Grassmann, Jessica; Lu, Mingyang; Palucka, Karolina; Kaminski, Naftali; Koff, Jonathan L; Williams, Adam American journal of physiology. Lung cellular and molecular physiology 2022 Apr;
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Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations.
Gertie, Jake A; Zhang, Biyan; Liu, Elise G; Hoyt, Laura R; Yin, Xiangyun; Xu, Lan; Long, Lauren L; Soldatenko, Arielle; Gowthaman, Uthaman; Williams, Adam; Eisenbarth, Stephanie C The Journal of allergy and clinical immunology 2021 May;
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3D Bioprinting for fabrication of tissue models of COVID-19 infection.
Kabir, Anisha; Datta, Pallab; Oh, Julia; Williams, Adam; Ozbolat, Veli; Unutmaz, Derya; T Ozbolat, Ibrahim Essays in biochemistry 2021 May;
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Atypical is the new norm, for B cells and the rest of us.
Williams, Adam; Eisenbarth, Stephanie C Science immunology 2021 Apr;6(58):
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Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.
Zhang, Yalan; Varela, Luis; Szigeti-Buck, Klara; Williams, Adam; Stoiljkovic, Milan; Šestan-Peša, Matija; Henao-Mejia, Jorge; D'Acunzo, Pasquale; Levy, Efrat; Flavell, Richard A; Horvath, Tamas L; Kaczmarek, Leonard K Nature communications 2021 Mar;12(1):1731
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Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.
Ravindra, Neal G; Alfajaro, Mia Madel; Gasque, Victor; Huston, Nicholas C; Wan, Han; Szigeti-Buck, Klara; Yasumoto, Yuki; Greaney, Allison M; Habet, Victoria; Chow, Ryan D; Chen, Jennifer S; Wei, Jin; Filler, Renata B; Wang, Bao; Wang, Guilin; Niklason, Laura E; Montgomery, Ruth R; Eisenbarth, Stephanie C; Chen, Sidi; Williams, Adam; Iwasaki, Akiko; Horvath, Tamas L; Foxman, Ellen F; Pierce, Richard W; Pyle, Anna Marie; van Dijk, David; Wilen, Craig B PLoS biology 2021 Mar;19(3):e3001143
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An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
Harman, Christian C D; Bailis, Will; Zhao, Jun; Hill, Louisa; Qu, Rihao; Jackson, Ruaidhrí P; Shyer, Justin A; Steach, Holly R; Kluger, Yuval; Goff, Loyal A; Rinn, John L; Williams, Adam; Henao-Mejia, Jorge; Flavell, Richard A Proceedings of the National Academy of Sciences of the United States of America 2021 Jan;118(3):
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Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28.
Lawlor, Nathan; Nehar-Belaid, Djamel; Grassmann, Jessica D S; Stoeckius, Marlon; Smibert, Peter; Stitzel, Michael L; Pascual, Virginia; Banchereau, Jacques; Williams, Adam; Ucar, Duygu Frontiers in immunology 2021 Jan;12636720
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Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by pro-inflammatory cytokine induced lncRNA Morrbid.
Cai, Zhigang; Lu, Xiaoyu; Zhang, Chi; Nelanuthala, Sai; Aguilera, Fabiola; Hadley, Abigail; Ramdas, Baskar; Fang, Fang; Nephew, Kenneth P; Kotzin, Jonathan J; Williams, Adam; Henao-Mejia, Jorge; Haneline, Laura S; Kapur, Reuben The Journal of clinical investigation 2020 Oct;
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Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia.
Cai, Zhigang; Zhang, Chi; Kotzin, Jonathan J; Williams, Adam; Henao-Mejia, Jorge; Kapur, Reuben Blood advances 2020 Jul;4(14):3246-3251
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Flow cytometric identification of Tfh13 cells in mouse and human.
Chen, Jennifer S; Grassmann, Jessica D S; Gowthaman, Uthaman; Olyha, Sam J; Simoneau, Tregony; Berin, M Cecilia; Eisenbarth, Stephanie C; Williams, Adam The Journal of allergy and clinical immunology 2020 Jul;
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Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells.
Cai, Zhigang; Aguilera, Fabiola; Ramdas, Baskar; Daulatabad, Swapna Vidhur; Srivastava, Rajneesh; Kotzin, Jonathan J; Carroll, Martin; Wertheim, Gerald; Williams, Adam; Janga, Sarath Chandra; Zhang, Chi; Henao-Mejia, Jorge; Kapur, Reuben Cell reports 2020 Jun;31(12):107816
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Long non-coding RNAs in immune regulation and their potential as therapeutic targets.
Uthaya Kumar, Dinesh Babu; Williams, Adam International immunopharmacology 2020 Apr;81106279
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miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells.
Lim, Clarice X; Lee, Bernett; Geiger, Olivia; Passegger, Christina; Beitzinger, Michaela; Romberger, Johann; Stracke, Anika; Högenauer, Christoph; Stift, Anton; Stoiber, Heribert; Poidinger, Michael; Zebisch, Armin; Meister, Gunter; Williams, Adam; Flavell, Richard A; Henao-Mejia, Jorge; Strobl, Herbert Cell reports 2020 Mar;30(11):3793-3805.e5
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The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis.
Lewandowski, Jordan P; Lee, James C; Hwang, Taeyoung; Sunwoo, Hongjae; Goldstein, Jill M; Groff, Abigail F; Chang, Nydia P; Mallard, William; Williams, Adam; Henao-Meija, Jorge; Flavell, Richard A; Lee, Jeannie T; Gerhardinger, Chiara; Wagers, Amy J; Rinn, John L Nature communications 2019 Nov;10(1):5137
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Identification of a T follicular helper cell subset that drives anaphylactic IgE.
Gowthaman, Uthaman; Chen, Jennifer S; Zhang, Biyan; Flynn, William F; Lu, Yisi; Song, Wenzhi; Joseph, Julie; Gertie, Jake A; Xu, Lan; Collet, Magalie A; Grassmann, Jessica D S; Simoneau, Tregony; Chiang, David; Berin, M Cecilia; Craft, Joseph E; Weinstein, Jason S; Williams, Adam; Eisenbarth, Stephanie C Science (New York, N.Y.) 2019 Aug;
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IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection.
Liu, Dong; Yin, Xiangyun; Olyha, Sam J; Nascimento, Manuela Sales L; Chen, Pei; White, Theresa; Gowthaman, Uthaman; Zhang, Tingting; Gertie, Jake A; Zhang, Biyan; Xu, Lan; Yurieva, Marina; Devine, Lesley; Williams, Adam; Eisenbarth, Stephanie C Immunity 2019 Jul;51(1):64-76.e7
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The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs.
Virtue, Anthony T; McCright, Sam J; Wright, Jasmine M; Jimenez, Monica T; Mowel, Walter K; Kotzin, Jonathan J; Joannas, Leonel; Basavappa, Megha G; Spencer, Sean P; Clark, Megan L; Eisennagel, Stephen H; Williams, Adam; Levy, Maayan; Manne, Sasikanth; Henrickson, Sarah E; Wherry, E John; Thaiss, Christoph A; Elinav, Eran; Henao-Mejia, Jorge Science translational medicine 2019 Jun;11(496):
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The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection.
Kotzin, Jonathan J; Iseka, Fany; Wright, Jasmine; Basavappa, Megha G; Clark, Megan L; Ali, Mohammed-Alkhatim; Abdel-Hakeem, Mohamed S; Robertson, Tanner F; Mowel, Walter K; Joannas, Leonel; Neal, Vanessa D; Spencer, Sean P; Syrett, Camille M; Anguera, Montserrat C; Williams, Adam; Wherry, E John; Henao-Mejia, Jorge Proceedings of the National Academy of Sciences of the United States of America 2019 Jun;116(24):11916-11925
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miR-181a/b downregulation exerts a protective action on mitochondrial disease models.
Indrieri, Alessia; Carrella, Sabrina; Romano, Alessia; Spaziano, Alessandra; Marrocco, Elena; Fernandez-Vizarra, Erika; Barbato, Sara; Pizzo, Mariateresa; Ezhova, Yulia; Golia, Francesca M; Ciampi, Ludovica; Tammaro, Roberta; Henao-Mejia, Jorge; Williams, Adam; Flavell, Richard A; De Leonibus, Elvira; Zeviani, Massimo; Surace, Enrico M; Banfi, Sandro; Franco, Brunella EMBO molecular medicine 2019 May;11(5):
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Structure and function of the immune system in the spleen.
Lewis, Steven M; Williams, Adam; Eisenbarth, Stephanie C Science immunology 2019 Mar;4(33):
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Editorial: Long Non-coding RNAs and Immunity.
Kwon, Grace J; Henao-Mejia, Jorge; Williams, Adam Frontiers in immunology 2019 Jan;102378
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Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis.
Cai, Zhigang; Kotzin, Jonathan J; Ramdas, Baskar; Chen, Sisi; Nelanuthala, Sai; Palam, Lakshmi Reddy; Pandey, Ruchi; Mali, Raghuveer Singh; Liu, Yan; Kelley, Mark R; Sandusky, George; Mohseni, Morvarid; Williams, Adam; Henao-Mejia, Jorge; Kapur, Reuben Cell stem cell 2018 Dec;23(6):833-849.e5
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Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development.
Stefanski, Heather E; Xing, Yan; Taylor, Patricia A; Maio, Stefano; Henao-Meija, Jorge; Williams, Adam; Flavell, Richard A; Hollander, Georg A; Blazar, Bruce R PloS one 2018 Jan;13(6):e0198871
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Migratory CD11b+ conventional dendritic cells induce T follicular helper cell-dependent antibody responses.
Krishnaswamy, Jayendra Kumar; Gowthaman, Uthaman; Zhang, Biyan; Mattsson, Johan; Szeponik, Louis; Liu, Dong; Wu, Renee; White, Theresa; Calabro, Samuele; Xu, Lan; Collet, Magalie A; Yurieva, Marina; Alsén, Samuel; Fogelstrand, Per; Walter, Anne; Heath, William R; Mueller, Scott N; Yrlid, Ulf; Williams, Adam; Eisenbarth, Stephanie C Science immunology 2017 Dec;2(18):
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Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.
Mowel, Walter K; McCright, Sam J; Kotzin, Jonathan J; Collet, Magalie A; Uyar, Asli; Chen, Xin; DeLaney, Alexandra; Spencer, Sean P; Virtue, Anthony T; Yang, EnJun; Villarino, Alejandro; Kurachi, Makoto; Dunagin, Margaret C; Pritchard, Gretchen Harms; Stein, Judith; Hughes, Cynthia; Fonseca-Pereira, Diogo; Veiga-Fernandes, Henrique; Raj, Arjun; Kambayashi, Taku; Brodsky, Igor E; O'Shea, John J; Wherry, E John; Goff, Loyal A; Rinn, John L; Williams, Adam; Flavell, Richard A; Henao-Mejia, Jorge Immunity 2017 Sep;47(3):435-449.e8
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Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity.
Calabro, Samuele; Liu, Dong; Gallman, Antonia; Nascimento, Manuela Sales L; Yu, Zizi; Zhang, Ting-Ting; Chen, Pei; Zhang, Biyan; Xu, Lan; Gowthaman, Uthaman; Krishnaswamy, Jayendra Kumar; Haberman, Ann M; Williams, Adam; Eisenbarth, Stephanie C Cell reports 2016 Aug;16(9):2472-85
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The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan.
Kotzin, Jonathan J; Spencer, Sean P; McCright, Sam J; Kumar, Dinesh B Uthaya; Collet, Magalie A; Mowel, Walter K; Elliott, Ellen N; Uyar, Asli; Makiya, Michelle A; Dunagin, Margaret C; Harman, Christian C D; Virtue, Anthony T; Zhu, Stella; Bailis, Will; Stein, Judith; Hughes, Cynthia; Raj, Arjun; Wherry, E John; Goff, Loyal A; Klion, Amy D; Rinn, John L; Williams, Adam; Flavell, Richard A; Henao-Mejia, Jorge Nature 2016 Aug;537(7619):239-243
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Bridging channel dendritic cells induce immunity to transfused red blood cells.
Calabro, Samuele; Gallman, Antonia; Gowthaman, Uthaman; Liu, Dong; Chen, Pei; Liu, Jingchun; Krishnaswamy, Jayendra Kumar; Nascimento, Manuela Sales L; Xu, Lan; Patel, Seema R; Williams, Adam; Tormey, Christopher A; Hod, Eldad A; Spitalnik, Steven L; Zimring, James C; Hendrickson, Jeanne E; Stowell, Sean R; Eisenbarth, Stephanie C The Journal of experimental medicine 2016 May;213887-96
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Editing the Mouse Genome Using the CRISPR-Cas9 System.
Williams, Adam; Henao-Mejia, Jorge; Flavell, Richard A Cold Spring Harbor protocols 2016 Jan;2016(2):pdb.top087536
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Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System.
Henao-Mejia, Jorge; Williams, Adam; Rongvaux, Anthony; Stein, Judith; Hughes, Cynthia; Flavell, Richard A Cold Spring Harbor protocols 2016 Jan;2016(2):pdb.prot090704
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Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
Krishnaswamy, Jayendra Kumar; Singh, Arpita; Gowthaman, Uthaman; Wu, Renee; Gorrepati, Pavane; Sales Nascimento, Manuela; Gallman, Antonia; Liu, Dong; Rhebergen, Anne Marie; Calabro, Samuele; Xu, Lan; Ranney, Patricia; Srivastava, Anuj; Ranson, Matthew; Gorham, James D; McCaw, Zachary; Kleeberger, Steven R; Heinz, Leonhard X; Müller, André C; Bennett, Keiryn L; Superti-Furga, Giulio; Henao-Mejia, Jorge; Sutterwala, Fayyaz S; Williams, Adam; Flavell, Richard A; Eisenbarth, Stephanie C Proceedings of the National Academy of Sciences of the United States of America 2015 Mar;112(10):3056-61
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The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.
Henao-Mejia, Jorge; Williams, Adam; Goff, Loyal A; Staron, Matthew; Licona-Limón, Paula; Kaech, Susan M; Nakayama, Maki; Rinn, John L; Flavell, Richard A Immunity 2013 May;38(5):984-97
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Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.
Joly, Sophie; Eisenbarth, Stephanie C; Olivier, Alicia K; Williams, Adam; Kaplan, Daniel H; Cassel, Suzanne L; Flavell, Richard A; Sutterwala, Fayyaz S Journal of immunology (Baltimore, Md. : 1950) 2012 Nov;189(10):4713-7
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NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.
Eisenbarth, Stephanie C; Williams, Adam; Colegio, Oscar R; Meng, Hailong; Strowig, Till; Rongvaux, Anthony; Henao-Mejia, Jorge; Thaiss, Christoph A; Joly, Sophie; Gonzalez, David G; Xu, Lan; Zenewicz, Lauren A; Haberman, Ann M; Elinav, Eran; Kleinstein, Steven H; Sutterwala, Fayyaz S; Flavell, Richard A Nature 2012 Apr;484(7395):510-3
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CD8 locus nuclear dynamics during thymocyte development.
Ktistaki, Eleni; Garefalaki, Anna; Williams, Adam; Andrews, Simon R; Bell, Donald M; Foster, Katie E; Spilianakis, Charalampos G; Flavell, Richard A; Kosyakova, Nadezda; Trifonov, Vladmir; Liehr, Thomas; Kioussis, Dimitris Journal of immunology (Baltimore, Md. : 1950) 2010 May;184(10):5686-95
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The role of NOD-like Receptors in shaping adaptive immunity.
Williams, Adam; Flavell, Richard A; Eisenbarth, Stephanie C Current opinion in immunology 2010 Feb;22(1):34-40
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Chitin is a size-dependent regulator of macrophage TNF and IL-10 production.
Da Silva, Carla A; Chalouni, Cécile; Williams, Adam; Hartl, Dominik; Lee, Chun G; Elias, Jack A Journal of immunology (Baltimore, Md. : 1950) 2009 Mar;182(6):3573-82
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Generalized immune activation as a direct result of activated CD4+ T cell killing.
Marques, Rute; Williams, Adam; Eksmond, Urszula; Wullaert, Andy; Killeen, Nigel; Pasparakis, Manolis; Kioussis, Dimitris; Kassiotis, George Journal of biology 2009 Jan;8(10):93
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Position effect variegation and imprinting of transgenes in lymphocytes.
Williams, Adam; Harker, Nicola; Ktistaki, Eleni; Veiga-Fernandes, Henrique; Roderick, Kathleen; Tolaini, Mauro; Norton, Trisha; Williams, Keith; Kioussis, Dimitris Nucleic acids research 2008 Apr;36(7):2320-9
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Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.
Veiga-Fernandes, Henrique; Coles, Mark C; Foster, Katie E; Patel, Amisha; Williams, Adam; Natarajan, Dipa; Barlow, Amanda; Pachnis, Vassilis; Kioussis, Dimitris Nature 2007 Mar;446(7135):547-51
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Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression
Williams A*, Lee GR*, Spilianakis CG, Hwang SS, Eisenbarth SC, Flavell RA. (*Co-first authors) Proc Natl Acad Sci 2013 April 23 110
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Interchromosomal association and gene regulation in trans
Williams A, Spilianakis CG, Flavell RA. Trends Genet. 2010 Apr 26(4):188-197
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Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens
Wegmann F, Gartlan KH, Harandi AM, Brinckmann SA, Coccia M, Hillson WR, Kok WL, Cole S, Ho LP, Lambe T, Puthia M, Svanborg C, Scherer EM, Krashias G, Williams A, Blattman JN, Greenberg PD, Flavell RA, Moghaddam AE, Sheppard NC, Sattentau QJ. Nat Biotechnol 2012 Sep 30(9):883-888
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Rac GTPases play critical roles in early T cell development
Dumont C, Corsoni-Tadrzak A, Ruf S, de Boer J, Williams A, Turner M, Kioussis D, Tybulewicz VL. Blood. 2009 Apr 23 113(17):3990-3998
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The role of CTCF in regulating nuclear organization
Williams A, Flavell RA. J Exp Med. 2008 Apr 14 205(4):747-750
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Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre
Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL. Nat Struct Mol Biol. 2014 21(2):198-206
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Transgenic mice with hematopoietic and lymphoid specific expression of Cre
de Boer J*. Williams A*. Skavdis G. Harker N. Coles M. Tolaini M. Norton T. Williams K. Roderick K. Potocnik AJ. Kioussis D. (*Co-first authors). Eur J Immunol. 2003 Feb 33(2):314-325
