George Y. Wu, MD, PhDProfessor Emeritus
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- Education & Training
- Clinical Interests
- Teaching
- Committees & Organizations
- Research
- Lab Rotations
- Publications
- Presentations
Degree | Institution | Major |
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BS | University of Rochester | Chemistry |
MD, PhD | Albert Einstein College of Medicine | Medicine/Biochemistry |
Post-Graduate Training
Training | Institution | Specialty |
---|---|---|
Internship | Harlem Hospital Center | Medicine |
Residency | Harlem Hospital Center | Medicine |
Fellowship | Albert Einstein College of Medicine | Gastroenterology/Liver Disease |
Awards
Name of Award/Honor | Awarding Organization |
---|---|
Director, Clinical Research Center (International Division), Southwest Hospital, Chongqing, China | |
Fellow | American Association for the Study of Liver Diseases |
Top Doctor in the U.S. | U.S. News and World Report |
Fulbright Scholar | |
Guest Professorship | Faculty of Medicine, University of Osijek, Croatia |
Fulbright Specialist Roster | Council for International Exchange |
Fellow | American Gastroenterological Association |
Commendation | Moroccan American Society for Life Sciences |
Consultant Professorship | Shanghai Second Medical University |
Old Turks | Association of American Physicians |
Scientific Award | Chinese American Medical Society |
Herman Lopata Chair in Hepatitis Research | |
Gastroenterology Research Group Young Scientist Award | American Gastroenterological Association |
Young Turks | American Society for Clinical Investigation |
Stuart F. Wilson Young Faculty Research Award | |
Research Career Development Award | NIH |
Industry Research Scholar Award | American Gastroenterological Association |
Research Prize | American Liver Foundation |
Individual National Research Service Award | NIAMDD |
Postdoctoral Fellowship Award | American Liver Foundation |
Fellowship Award | Gail I. Zuckerman Foundation |
NIH Medical Scientist Trainee, M.D./Ph.D. Fellowship | Albert Einstein College of Medicine |
Phi Beta Kappa | University of Rochester |
General gastroenterology including diagnostic and therapeutic upper endoscopy and colonoscopy, ultrasound-assisted liver biopsy, and ultrasound-assisted paracentesis
Developed liver disease lectures and small group sessions for the 2nd year medical students in Disorders of Metabolism Course: “Complications of Chronic Liver Disease”, and “Serum Liver Tests” and “Fulminant Hepatic Failure”. Have been also involved in the UConn Mini-Medical School program since 2008 in which he annually presents a lecture: “Chronic Viral Hepatitis: What is it and why is it important?”, and was a mentor for shadowing of mini-medical students for cases in GI endoscopy, Careers in Gastroenterology. Served as a Selective advisor for 4th year medical students. Consult Attending, Endoscopy Attending, and medical residents in Continuity Clinic. Local, national and international reputation as a clinical lecturer. Since 2003, have presented 21 invited lectures abroad in China, India, Jordan, Egypt, Morocco, and Croatia.
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
---|---|---|---|---|---|---|
GI-Hepatology Fellowship Program | Education Committee | Member | UConn Health | University | 2004 | 2008 |
GI-Hepatology Fellowship Program | Education Committee | Director | UConn Health | University | 1989 | 2001 |
Clinical: New antiviral agents for the treatment of hepatitis C, and hepatitis B.
Basic Science: Targeted gene delivery, and most recently an immunocompetent animal model for HCV infection.
Not accepting students for Lab Rotations at this time
Journal Articles
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Prolonged Direct Hyperbilirubinemia Following Acute Hepatitis: When Not to Worry?
Journal of clinical and translational hepatology 2024 Dec;12(12):985-987
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Changes in Dickkopf-1, but Not Sclerostin, in Gingival Crevicular Fluid Are Associated with Peroral Statin Treatment in Patients with Periodontitis.
Medicina (Kaunas, Lithuania) 2024 Mar;60(3):
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Laryngopharyngeal Reflux Scoring in a Pediatric Population.
Journal of clinical medicine 2023 Nov;12(23):
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Liraglutide Exerts Protective Effects by Downregulation of PPARγ, ACSL1 and SREBP-1c in Huh7 Cell Culture Models of Non-Alcoholic Steatosis and Drug-Induced Steatosis.
Current issues in molecular biology 2022 Aug;44(8):3465-3480
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Liver and serum adiponectin levels in non-alcoholic fatty liver disease.
Journal of digestive diseases 2021 Apr;22(4):214-221
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Celiac Disease and Elevated Liver Enzymes: A Review.
Journal of clinical and translational hepatology 2021 Feb;9(1):116-124
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Cytomegalovirus Hepatitis in Immunocompetent and Immunocompromised Hosts.
Journal of clinical and translational hepatology 2021 Feb;9(1):106-115
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Impact of DAA Treatment on Cardiovascular Disease Risk in Chronic HCV Infection: An Update.
Frontiers in pharmacology 2021 Jan;12678546
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The accuracy of breast cancer risk self-assessment does not correlate with knowledge about breast cancer and knowledge and attitudes towards primary chemoprevention.
Preventive medicine reports 2020 Dec;20101229
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Impact of Breast Density Awareness on Knowledge about Breast Cancer Risk Factors and the Self-Perceived Risk of Breast Cancer.
Diagnostics (Basel, Switzerland) 2020 Jul;10(7):
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Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients' Population.
International journal of environmental research and public health 2020 May;17(10):
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Targeted Delivery of Mitochondria to Liver in Rats.
Journal of gastroenterology and hepatology 2020 May;
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Biliary Mucinous Cystadenoma: A Review of the Literature.
Journal of clinical and translational hepatology 2019 Jun;7(2):149-153
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Diagnostic and Therapeutic Strategies for Peritoneal Tuberculosis: A Review.
Journal of clinical and translational hepatology 2019 Jun;7(2):140-148
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HCV Extrahepatic Manifestations.
Journal of clinical and translational hepatology 2019 Jun;7(2):172-182
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An Improved Method for Preparation of Uniform and Functional Mitochondria from Fresh Liver.
Journal of clinical and translational hepatology 2019 Mar;7(1):46-50
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Mechanisms of Hepatic Cholestatic Drug Injury.
Journal of clinical and translational hepatology 2019 Mar;7(1):86-92
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Aortoenteric Fistula.
The Journal of the American Osteopathic Association 2019 Feb;119(2):135
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Primary Care Provider Counseling Practices about Adverse Drug Reactions and Interactions in Croatia.
Journal of clinical medicine 2018 Aug;7(9):
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Dysregulation of fibrosis related genes in HCV induced liver disease.
Gene 2018 Jul;66458-69
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Timing of treatment initiation of direct-acting antivirals for HIV/HCV coinfected and HCV monoinfected patients.
AIDS care 2018 Jul;301507-1511
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HCV Therapy Follow-up Fractionation (CTF2) by Intra-PBMC Nested RNA PCR Recognizes Early Virologic Response and Relapse.
Journal of clinical and translational hepatology 2018 Jun;6(2):147-154
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Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives.
Current drug metabolism 2018 May;19830-838
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Occult HCV Infection (OCI) Diagnosis in Cirrhotic and Non-cirrhotic Naïve Patients by Intra-PBMC Nested Viral RNA PCR.
Journal of clinical and translational hepatology 2017 Dec;5(4):319-326
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Targeted Transplantation of Mitochondria to Hepatocytes
Hepatic Medicine: Evidence and Research 2016 Dec;8115-134
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A Novel Dual Snare Technique for Removal of Long Sharp Foreign Bodies.
Journal of digestive diseases 2016 Jan;17274-276
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Secondary Structural Elements of the HCV X-region Involved in Viral Replication.
Journal of clinical and translational hepatology 2015 Jul;3(1):1-8
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Effects of short RNA structural analogues against hepatitis C virus genotypes 2, 3 and 4 in replicon cells.
Journal of digestive diseases 2015 Apr;16(8):449-55
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The Molecular and Structural Basis of HBV-Resistance to Nucleos(t)ide Analogs.
J Clin Trans Hepatol 2014 Dec;
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An ironic case of liver infections: Yersinia enterocolitis in the setting of thalassemia.
World journal of gastroenterology 2013 Oct;19(37):6296-8
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Sessile serrated adenomas in the proximal colon are likely to be flat, large and occur in smokers.
World journal of gastroenterology 2013 Aug;19(32):5271-7
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An engineered multidomain fungicidal peptide against plant fungal pathogens.
Sheng li xue bao : [Acta physiologica Sinica] 2013 Aug;65(4):417-32
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Pharmacogenetic selection of transplanted human hepatocytes in immunocompetent rats.
Journal of digestive diseases 2012 Nov;13(11):579-87
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Animal models for the study of hepatitis C virus infection and replication.
World journal of gastroenterology 2012 Jun;18(23):2909-13
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Endoscopic removal of a long sharp metallic foreign body by a snared magnet: an attractive solution.
Journal of digestive diseases 2012 Apr;13(4):239-41
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Granulomatous liver diseases: a review.
Journal of the Formosan Medical Association = Taiwan yi zhi 2012 Jan;111(1):3-13
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Effects of PEG-interferon-alpha-2A on Schistosoma mansoni infection in mice.
The Journal of parasitology 2010 Aug;96(4):703-8
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Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics.
World journal of gastroenterology 2010 May;16(17):2100-8
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Host susceptibility to schistosomes: effect of host sera on cell proliferation of Schistosoma mansoni schistosomula.
The Journal of parasitology 2008 Dec;94(6):1249-52
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Human uridine-cytidine kinase phosphorylation of ribavirin: a convenient method for activation of ribavirin for conjugation to proteins.
Journal of biomedical science 2008 Mar;15(2):205-13
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'Where the money is': a case report of the successful removal of a large number of coins by esophagogastroduodenoscopy utilizing a Roth net.
Journal of digestive diseases 2007 Aug;8(3):160-1
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The contribution of methotrexate exposure and host factors on transcriptional variance in human liver.
Toxicological sciences : an official journal of the Society of Toxicology 2007 Jun;97(2):582-94
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Positional effects and strand preference of RNA interference against hepatitis C virus target sequences.
Journal of viral hepatitis 2007 Mar;14(3):194-212
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A novel G418 conjugate results in targeted selection of genetically protected hepatocytes without bystander toxicity.
Bioconjugate chemistry 2007 Jan;18(6):1965-71
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siRNA-resistance in treated HCV replicon cells is correlated with the development of specific HCV mutations.
Journal of viral hepatitis 2006 Nov;13(11):756-61
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Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells.
Molecular biology of the cell 2005 Sep;16(9):4398-409
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Endogenously expressed multimeric self-cleaving hammerhead ribozymes ablate mutant collagen in cellulo.
Molecular therapy : the journal of the American Society of Gene Therapy 2005 Jul;12(1):128-36
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A novel immunocompetent rat model of HCV infection and hepatitis.
Gastroenterology 2005 May;128(5):1416-23
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A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis.
Antimicrobial agents and chemotherapy 2005 Mar;49(3):1184-9
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Secondary structure and hybridization accessibility of the hepatitis C virus negative strand RNA 5'-terminus.
Journal of viral hepatitis 2004 Mar;11(2):115-23
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PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2004 Feb;101(8):2311-6
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Delivery of hepatitis B virus therapeutic agents using asialoglycoprotein receptor-based liver-specific targeting.
Methods in molecular medicine 2004 Jan;96163-73
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An engineered multidomain bactericidal peptide as a model for targeted antibiotics against specific bacteria.
Nature biotechnology 2003 Dec;21(12):1480-5
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Enhanced intracellular availability and survival of hammerhead ribozymes increases target ablation in a cellular model of osteogenesis imperfecta.
Gene therapy 2003 Nov;10(24):2005-12
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Inhibition of HBV replication by siRNA in a stable HBV-producing cell line.
Hepatology (Baltimore, Md.) 2003 Oct;38(4):842-50
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Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.
Cell 2003 Jul;114(2):215-27
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Hepatitis B virus infection of transplanted human hepatocytes causes a biochemical and histological hepatitis in immunocopetentent rats.
World journal of gastroenterology 2003 May;9(5):978-83
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Conjugation of an antisense oligodeoxynucleotide to ribonuclease h results in sequence-specific cleavage and intracellular inhibition of HCV gene expression.
Bioconjugate chemistry 2003 Jan;14(2):295-301
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Secondary structure and hybridization accessibility of hepatitis C virus 3'-terminal sequences.
Journal of virology 2002 Oct;76(19):9563-74
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Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1.
The Journal of biological chemistry 2002 Sep;277(38):35156-61
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Evaluation of multicomponent non-viral vectors for liver directed gene delivery.
Journal of drug targeting 2002 Mar;10(2):105-11
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Targeted gene transfer to liver using protein-DNA complexes.
Methods in molecular medicine 2002 Jan;6915-23
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Liver cell transplantation -- novel animal model for human hepatic viral infections.
Croatian medical journal 2001 Aug;42(4):446-50
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Targeted polynucleotides for inhibition of hepatitis B and C viruses.
Croatian medical journal 2001 Aug;42(4):463-6
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Transplantation of human hepatocytes into tolerized genetically immunocompetent rats.
World journal of gastroenterology 2001 Jun;7(3):324-30
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Human hepatocytes transplanted into genetically immunocompetent rats are susceptible to infection by hepatitis B virus in situ.
Journal of viral hepatitis 2001 Mar;8(2):111-9
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A ribonuclease H-oligo DNA conjugate that specifically cleaves hepatitis B viral messenger RNA.
Bioconjugate chemistry 2001 Jan;12(5):770-5
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Transplantation of human hepatocytes into tolerized genetically immunocompetent rats.
World Journal of Gastroenterology 2001 Jan;7324-330
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Transfection and expression of HCV-NS5B gene in Huh-7 cells.
Chinese medical journal 2000 Jul;113(7):602-5
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Gene therapy for metabolic diseases of the liver.
BioDrugs 2000 Jan;13177-188
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Genetic therapy of hepatic diseases.
Gut 2000 Jan;46136-139
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Hydrodynamic delivery.
Advances in genetics 2000 Jan;8989-111
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Liver-selective nucleic acid targeting using the asialoglycoprotein receptor.
Gene Ther Reg 2000 Jan;179-94
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Targeted inhibition of type I procollagen synthesis by antisense DNA oligonucleotides.
Gene Ther Reg 2000 Jan;11-13
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A DNA delivery system containing listeriolysin O results in enhanced hepatocyte-directed gene expression.
World journal of gastroenterology : WJG 1999 Dec;5(6):465-469
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Inhibition of hepatitis C virus-directed gene expression by a DNA ribonuclease.
Journal of hepatology 1999 Oct;31(4):628-34
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A method for purification of listeriolysin O from a hypersecretor strain of Listeria monocytogenes.
Protein expression and purification 1999 Mar;15(2):243-5
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Multicomponent DNA carrier with a vesicular stomatitis virus G-peptide greatly enhances liver-targeted gene expression in mice.
Bioconjugate chemistry 1999 Jan;10(6):1075-83
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Human portal serum stimulates cell proliferation in immature Schistosoma mansoni.
Parasitology 1998 Oct;117 ( Pt 4)(4):293-9
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Chimeric oligonucleotides: an exciting answer that raises more questions.
Hepatology (Baltimore, Md.) 1998 Aug;28(2):594-6
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DNA ribonucleases that are active against intracellular hepatitis B viral RNA targets.
Hepatology (Baltimore, Md.) 1998 Aug;28(2):547-54
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Targeted inhibition of hepatitis C virus-directed gene expression in human hepatoma cell lines.
Gastroenterology 1998 Jun;114(6):1304-12
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Recent advances in gene therapy of GI and liver diseases.
Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui 1998 Jan;39(5):297-300
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Receptor-mediated delivery of foreign genes to hepatocytes.
Adv. Drug Del. Revs. 1998 Jan;29243-248
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Design and preparation of a multimeric self-cleaving hammerhead ribozyme.
BioTechniques 1997 Feb;22(2):338-45
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Listeriolysin O potentiates immunotoxin and bleomycin cytotoxicity.
Bioconjugate chemistry 1997 Jan;8(6):781-4
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Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes.
The Journal of clinical investigation 1996 Dec;98(12):2720-8
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Delivery of a hammerhead ribozyme specifically down-regulates the production of fibrillin-1 by cultured dermal fibroblasts.
Human molecular genetics 1996 Dec;5(12):1939-44
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Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro.
Hepatology (Baltimore, Md.) 1996 Jun;23(6):1297-303
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A collagen enhancer-promoter construct in transgenic mice is markedly stimulated by ethanol administration.
Hepatology (Baltimore, Md.) 1996 Feb;23(2):310-5
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Microtubular disruption prolongs the expression of human bilirubin-uridinediphosphoglucuronate-glucuronosyltransferase-1 gene transferred into Gunn rat livers.
The Journal of biological chemistry 1996 Jan;271(4):2341-6
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A hepatocyte-targeted conjugate capable of delivering biologically active colchicine in vitro.
Bioconjugate chemistry 1996 Jan;7(1):131-7
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Fate of DNA targeted to hepatocytes by asialoglycoprotein polylysine conjugates.
Proceedings of the Association of American Physicians 1995 Jul;107(2):211-7
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Depolymerization of hepatocellular microtubules after partial hepatectomy.
The Journal of biological chemistry 1994 Oct;269(40):25200-5
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Incorporation of adenovirus into a ligand-based DNA carrier system results in retention of original receptor specificity and enhances targeted gene expression.
The Journal of biological chemistry 1994 Apr;269(15):11542-6
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Preparation of asialoorosomucoid-polylysine conjugates.
Bioconjugate chemistry 1994 Jan;5(4):306-11
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Lipocytes from fibrotic rat liver have an impaired feedback response to procollagen propeptides.
The American journal of physiology 1993 Jan;264(1 Pt 1):G157-62
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Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides.
The Journal of biological chemistry 1992 Jun;267(18):12436-9
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Evidence that an iron chelator regulates collagen synthesis by decreasing the stability of procollagen mRNA.
Hepatology (Baltimore, Md.) 1992 Feb;15(2):282-7
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Chemical modification of an ecotropic murine leukemia virus results in redirection of its target cell specificity.
The Journal of biological chemistry 1991 Aug;266(22):14143-6
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Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats.
The Journal of biological chemistry 1991 Aug;266(22):14338-42
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Propeptide-mediated regulation of procollagen synthesis in IMR-90 human lung fibroblast cell cultures. Evidence for transcriptional control.
The Journal of biological chemistry 1991 Feb;266(5):2983-7
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Targeted protection of hepatocytes from galactosamine toxicity in vivo.
Cancer chemotherapy and pharmacology 1990 Jan;26(2):93-6
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Targeting genes: delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo.
The Journal of biological chemistry 1989 Oct;264(29):16985-7
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Immunotargeting in the diagnosis and treatment of liver cancer.
Hepatology (Baltimore, Md.) 1989 Apr;9(4):646-8
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Receptor-mediated gene delivery and expression in vivo.
The Journal of biological chemistry 1988 Oct;263(29):14621-4
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Targeted antagonism of galactosamine toxicity in normal rat hepatocytes in vitro.
The Journal of biological chemistry 1988 Apr;263(10):4719-23
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Evidence for targeted gene delivery to Hep G2 hepatoma cells in vitro.
Biochemistry 1988 Feb;27(3):887-92
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Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.
The Journal of biological chemistry 1987 Apr;262(10):4429-32
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Targeted inhibition of transferrin-mediated iron uptake in Hep G2 hepatoma cells.
The Journal of biological chemistry 1986 Dec;261(36):16834-7
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Evidence for pretranslational regulation of collagen synthesis by procollagen propeptides.
The Journal of biological chemistry 1986 Aug;261(23):10482-4
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Portal serum constituents possible determinants for anatomical localization ofSchistosoma mansoni during maturation and reproduction.
Journal of chemical ecology 1986 Aug;12(8):1797-803
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Limitation on sensitivity of measuring collagen degradation: studies with cultured liver cells.
Connective tissue research 1986 Jan;14(3):213-9
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Portal serum constituents possible determinants for anatomical localization of Schistosoma mansoni during maturation and reproduction
Journal of Chemical Ecology 1986 Jan;12(8):1797-1803
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Stimulation of Schistosoma mansoni oviposition in vitro by animal and human portal serum.
The American journal of tropical medicine and hygiene 1985 Jul;34(4):750-3
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In-vitro catabolism of L-histidine by adult Schistosoma mansoni.
Journal of the Egyptian Society of Parasitology 1985 Jun;15(1):29-39
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Periodate oxidation products of hydroxylysine in the synthesis of 5-substituted prolines.
Analytical biochemistry 1985 May;147(1):103-7
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Acetaminophen hepatotoxicity and targeted rescue: a model for specific chemotherapy of hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 1985 Jan;5(5):709-13
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Activity and regulation of low density lipoprotein receptors in a human hepatoblastoma cell line.
Hepatology (Baltimore, Md.) 1984 Jan;4(6):1190-4
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Model for specific rescue of normal hepatocytes during methotrexate treatment of hepatic malignancy.
Proceedings of the National Academy of Sciences of the United States of America 1983 May;80(10):3078-80
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Specificity of trypsin and carboxypeptidase B for hydroxylysine residues in denatured collagens.
Biochemistry 1981 Jul;20(15):4321-4
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A new method for the preparation of delta 1-pyrroline 5-carboxylic acid and proline.
Analytical biochemistry 1975 Aug;67(2):413-21
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The 24-hour plasma thyroxin profile in normal man.
The Journal of clinical endocrinology and metabolism 1974 Oct;39(4):765-71
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Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography.
Hepatology (Baltimore, Md.) 1(6):622-7
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Development of molecular hybridization technology to evaluate albumin and procollagen mRNA content in baboons and man.
Hepatology (Baltimore, Md.) 7(1 Suppl):19S-25S
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The nature of the collagen in hepatic fibrosis in advanced murine schistosomiasis.
Hepatology (Baltimore, Md.) 2(3):366-71
Books
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Diagnostic and Therapeutic Procedures in Gastroenterology, An Illustrated Guide
Clinical Gastroenterology 2018 Jan;
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Pocket Handbook of Gastrointestinal Pharmacotherapeutics, 2nd ed.
Pocket Handbook of Gastrointestinal Pharmacotherapeutics, 2nd ed. 2016 Aug;
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Diagnostic and Therapeutic Procedures in Gastroenterology: An Illustrated Guide 2011 Jul;
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Molecular Diagnosis and Gene Therapy 1996 Jan;
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Liver Diseases: Diagnosis and Therapy Using Specific Receptors and Ligands 1991 Jan;
Book Chapters
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Ultrasound-Guided/Ultrasound-Assisted Percutaneous Liver Biopsy
Diagnostic and Therapeutic Procedures in Gastroenterology 2018 Feb;339-347
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A Brief Update on the Treatment of Hepatitis C
Proceedings of the 3rd International Monothematic Conference on Viral Hepatitis C 2017 Jan;
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The Molecular Basis of Anti-HCV Drug Resistance
Proceedings of the 3rd International Monothematic Conference on Viral Hepatitis C 2017 Jan;
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Hepatitis
Pocket Handbook of GI Pharmacotherapeutics 2016 Aug;113-138
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Pruritus
Pocket Handbook of GI Pharmacotherapeutics 2016 Aug;157-166
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Polymeric Biomaterials
Biocompatible polymers in liver-targeted gene delivery systems 2002 Jan;975-982
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Meth. Mole. Med. – Nonviral Vectors for Gene Therapy: Methods and Protocols
Progress Towards a Synthetic Virus: A Multicomponent System for Liver-Directed DNA Delivery 2001 Jan;
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Progress in Gene Therapy - Basic and Clinical Frontiers
Liver-selective nucleic acid targeting using the asialoglycoprotein receptor 2000 Jan;
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Current Concepts of Gene Therapy
Targeted gene delivery and expression in hepatocytes 1997 Jan;
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Gene Therapy Protocols
Methods for Targeted Gene Trans¬fer to Liver Using DNA-Protein Complexes 1997 Jan;
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Molecular Diagnosis and Gene Therapy
Gene therapy for hepatic diseases 1997 Jan;
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Treatments in Hepatology
Gene therapy and liver diseases 1995 Jan;
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Methods in Enzymol.
Ligand-based carrier systems for delivery of DNA to hepatocytes 1994 Jan;
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Neoglycoconjugates: Preparation and Application
Delivery of polynucleotides to hepatocytes 1994 Jan;
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Extrahepatic Manifestations of Liver Diseases
Advances in gene therapy for liver diseases 1993 Jan;
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Progress in Liver Diseases
Methods of gene transfer into hepatocytes: Progress toward gene therapy 1992 Jan;
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Seminars in Liver Disease
Strategies for gene therapy in the liver 1992 Jan;
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Etiology, Pathology, and Treatment of Hepatocellular Carcinoma in North America
Experimental therapeutic modalities for hepatocellular carcinoma 1991 Jan;
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Targeted Diagnosis and Therapy of Liver Diseases: Cell Surface Receptors and Liver Directed Agents
Targeted delivery and expression of foreign genes in hepatocytes 1991 Jan;
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Therapy of Genetic Diseases
Delivery and expression of genes in hepatocytes 1991 Jan;
Case Reports
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Esophageal Squamous Papilloma: A Case Series and Literature Review.
Journal of digestive diseases 2017 Aug;19254-256
Conference Papers
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Gene therapy for viral hepatitis: Prospects for the design and delivery of nucleic acid pharmaceuticals
Viral Hepatitis Reviews 2000 Jan;6(4-Jan):129-141
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Gene therapy: Recent advances and applications in gastroenterology and hepatology
Journal of Gastroenterology and Hepatology 1998 Jan;13(SUPPL. NOV.):
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Targeted therapy for viral hepatitis
Advanced Drug Delivery Reviews 1995 Jan;17(3):311-315
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Receptor-mediated gene delivery and expression in hepatocytes
European Journal of Pharmacology 1990 Jan;183(1):147
Editorials
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Non-alcoholic fatty liver disease and the metabolic syndrome: effects of weight loss and a review of popular diets. Are low carbohydrate diets the answer?
World journal of gastroenterology 2006 Jan;12(3):345-53
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Gene therapy for hepatocellular carcinoma: progress but many stones yet unturned!
Gastroenterology 1997 Feb;112(2):656-9
Letters
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Reply to Testino
Journal of the Formosan Medical Association 2009 Jan;108(3):264
Monographs
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Autoimmune Hepatitis
BMJ Best Practice 2019 Apr;
Notes
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Getting to the core of the matter.
Nature medicine 1995 Mar;1(3):210-1
Reviews
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Effects of Transjugular Intrahepatic Portosystemic Shunt on Renal and Pulmonary Function in Hepatic Decompensation with and without Hepatorenal and Hepatopulmonary Syndromes: A Review.
Journal of clinical and translational hepatology 2024 Sep;12(9):780-791
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Heritable Chronic Cholestatic Liver Diseases: A Review.
Journal of clinical and translational hepatology 2024 Aug;12(8):726-738
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Subnormal Serum Liver Enzyme Levels: A Review of Pathophysiology and Clinical Significance.
Journal of clinical and translational hepatology 2024 Apr;12(4):428-435
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Genetics of Gallstone Disease and Their Clinical Significance: A Narrative Review.
Journal of clinical and translational hepatology 2024 Mar;12(3):316-326
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Focal Nodular Hyperplasia: A Comprehensive Review with a Particular Focus on Pathogenesis and Complications.
Journal of clinical and translational hepatology 2024 Feb;12(2):182-190
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Unique Genetic Features of Lean NAFLD: A Review of Mechanisms and Clinical Implications.
Journal of clinical and translational hepatology 2024 Jan;12(1):70-78
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Novel Approaches to Inhibition of HBsAg Expression from cccDNA and Chromosomal Integrants: A Review.
Journal of clinical and translational hepatology 2023 Dec;11(7):1485-1497
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Noninvasive Fibrosis Assessment in Chronic Hepatitis C Infection: An Update.
Journal of clinical and translational hepatology 2023 Oct;11(5):1228-1238
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Biomarkers for Assessing Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus on Sodium-Glucose Cotransporter 2 Inhibitor Therapy.
Journal of clinical medicine 2023 Oct;12(20):
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Primary Hepatic Extra-gastrointestinal Stromal Tumors: Molecular Pathogenesis, Immunohistopathology, and Treatment.
Journal of clinical and translational hepatology 2023 Aug;11(4):942-948
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Primary Non-HFE Hemochromatosis: A Review.
Journal of clinical and translational hepatology 2023 Aug;11(4):925-931
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Seronegative Autoimmune Hepatitis.
Journal of clinical and translational hepatology 2023 Apr;11(2):459-465
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Immunotherapy-induced Hepatotoxicity: A Review.
Journal of clinical and translational hepatology 2022 Dec;10(6):1194-1204
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Therapeutic Perspectives of IL1 Family Members in Liver Diseases: An Update.
Journal of clinical and translational hepatology 2022 Dec;10(6):1186-1193
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Targeted Mitochondrial Delivery to Hepatocytes: A Review.
Journal of clinical and translational hepatology 2022 Apr;10(2):321-328
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Persistently Rising Alpha-fetoprotein in the Diagnosis of Hepatocellular Carcinoma: A Review.
Journal of clinical and translational hepatology 2022 Feb;10(1):159-163
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Drug-induced Fatty Liver Disease: Pathogenesis and Treatment
J Clin Transl Hepatol 2021 Oct;9(5):731-737
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Novel Agents in the Management of Hepatic Encephalopathy: A Review
J Clin Transl Hepatol 2021 Oct;9(5):749-759
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HBV-HCV Coinfection: Viral Interactions, Management, and Viral Reactivation.
Journal of clinical and translational hepatology 2018 Sep;6(3):296-305
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Occult Hepatitis C Virus Infection: A Review.
Journal of clinical and translational hepatology 2018 Jun;6(2):155-160
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Hepatitis caused by herpes group viruses: A review.
Journal of digestive diseases 2018 Jun;19446-455
-
Chylous Ascites: A Review of Pathogenesis, Diagnosis and Treatment.
Journal of clinical and translational hepatology 2018 Mar;6(1):105-113
-
Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis.
Journal of clinical and translational hepatology 2017 Jun;5(2):119-129
-
Vascular Diseases of the Spleen: A Review.
Journal of clinical and translational hepatology 2017 Jun;5(2):152-164
-
Dermatologic Extrahepatic Manifestations of Hepatitis C.
Journal of clinical and translational hepatology 2015 Jun;3(2):127-33
-
A review of methotrexate-associated hepatotoxicity.
Journal of digestive diseases 2014 Aug;15(10):517-24
-
Intra-abdominal complications of sarcoidosis.
Journal of the Formosan Medical Association = Taiwan yi zhi 2010 Jul;109(7):484-92
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Eosinophilic Digestive Diseases: Eosinophilic Esophagitis, Gastroenteritis, and Colitis
Journal of the Formosan Medical Association 2009 Jan;108(11):834-843
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Nonalcoholic fatty liver disease and low-carbohydrate diets.
Annual review of nutrition 2009 Jan;29365-79
-
Non-alcoholic steatohepatitis: an overview.
Journal of the Formosan Medical Association = Taiwan yi zhi 2009 Jan;108(1):4-12
-
Prospects for future therapy of HCV infection
Future Virology 2009 Jan;4(5):453-462
-
Potential role of RNAi in the treatment of HCV infection.
Expert review of anti-infective therapy 2007 Oct;5(5):823-31
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Drug evaluation: Albuferon-alpha--an antiviral interferon-alpha/albumin fusion protein.
Current opinion in investigational drugs (London, England : 2000) 2006 Aug;7(8):750-8
-
Potential applications of siRNA in hepatitis C virus therapy.
Current opinion in investigational drugs (London, England : 2000) 2006 Feb;7(2):142-6
-
Autoimmune hepatitis triggered by statins
Journal of Clinical Gastroenterology 2006 Jan;40(8):757-761
-
Novel delivery methods for treatment of viral hepatitis: an update.
Expert opinion on drug delivery 2005 Jul;2(4):707-17
-
Cell culture and animal models for human viral hepatitis
Hepatology Research 2004 Jan;28(2):61-67
-
Structure-based design of hepatitis C virus inhibitors.
Journal of viral hepatitis 2003 Nov;10(6):405-12
-
Extrahepatic manifestations of chronic hepatitis C
Chinese Journal of Digestive Diseases 2003 Jan;4(3):93-99
-
Prokinetic therapy for gastroenterological diseases
Chinese Journal of Digestive Diseases 2003 Jan;4(4):151-159
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Hepatitis C and HIV co-infection: a review.
World journal of gastroenterology 2002 Aug;8(4):577-9
-
Gene therapy for metabolic diseases of the liver
BioDrugs 2000 Jan;13(3):177-188
-
Gene therapy of hepatic diseases: prospects for the new millennium.
Gut 2000 Jan;46(1):136-9
-
Hepatic Fibrosis - A Mini Review
Chinese J Gastro 2000 Jan;580-83
-
Schistosomiasis: Progress and problems
World Journal of Gastroenterology 2000 Jan;6(1):12-19
-
Hepatocyte-directed gene delivery by receptor-mediated endocytosis.
Seminars in liver disease 1999 Jan;19(1):83-92
-
Pre-clinical trials using hepatic gene delivery.
Advanced drug delivery reviews 1998 Mar;30(1-3):199-204
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Liver-selective DNA targeting using the asialoglycoprotein receptor
Biogenic Amines 1998 Jan;14(5):499-518
-
Receptor-mediated delivery of foreign genes to hepatocytes
Advanced Drug Delivery Reviews 1998 Jan;29(3):243-248
-
Targeted therapy for viral hepatitis
Drugs of Today 1996 Jan;32(8):653-661
-
Prospects of therapy of liver diseases with foreign genes.
Seminars in liver disease 1995 Aug;15(3):257-67
-
Hepatocellular carcinoma: update on diagnosis and treatment.
Digestive diseases (Basel, Switzerland) 1995 Jan;13(2):81-91
-
Gene therapy: applications to the treatment of gastrointestinal and liver diseases.
Gastroenterology 1994 Apr;106(4):1076-84
-
Therapeutic implications of delivery and expression of foreign genes in hepatocytes.
Advances in pharmacology (San Diego, Calif.) 1994 Jan;28169-92
-
Liver-directed gene delivery
Advanced Drug Delivery Reviews 1993 Jan;12(3):159-167
-
Strategies for gene therapy in the liver.
Seminars in liver disease 1992 Aug;12(3):332-9
-
Methods of gene transfer into hepatocytes: progress toward gene therapy.
Progress in liver diseases 1992 Jan;101-24
-
Delivery systems for gene therapy.
Biotherapy (Dordrecht, Netherlands) 1991 Jan;3(1):87-95
-
Receptor-mediated protection of normal hepatocytes during chemotherapy for hepatocellular carcinoma.
Targeted diagnosis and therapy 1991 Jan;4105-25
-
Targeted delivery and expression of foreign genes in hepatocytes.
Targeted diagnosis and therapy 1991 Jan;4127-49
-
-
Short Surveys
-
ALN-RSV01: siRNA targeting RSV nucleocapsid N gene treatment of RSV infection
Drugs of the Future 2009 Jan;34(10):781-783
-
Research advances in the development of peptide antibiotics.
Journal of pharmaceutical sciences 2008 Mar;97(3):1060-70
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
---|---|---|---|---|
The Molecular and Clinical Bases of Anti-HCV Drug ResistanceThe Molecular and Clinical Bases of Anti-HCV Drug Resistance | Plenary Lecture | Egyptian Society of Updates in Hepatology and Gastroenterology | 2017 | Cairo, Egypt |
“Eosinophilic Esophagitis” | Lecture | Medical Grand Rounds | 2016 | Manchester Memorial Hospital |
“Up and Down the GI Tract- A Update” | Lecture | Interstate Physicians Medical Association | 2016 | San Antonio, TX |
“Wilson’s Disease” | Lecture | Medical Grand Rounds | 2016 | Manchester Hospital |
"HCV Update" | Lecture | Medical Grand Rounds | 2016 | Rockville General Hospital |
“Complications of Chronic Liver Disease” | Lecture | University of New England College of Osteopathic Medicine | 2016 | Manchester Memorial Hospital |
“Acute Hepatitis” | Lecture | Resident’s Noon Lecture | 2016 | UCONN |
“The Molecular Basis of HCV Resistance to Antiviral Agents” | Lecture | International Forum on Hepatitis | 2016 | Cairo, Egypt |
“Clinical Evidence of HCV GT-1 Resistance to Antiviral Agents” | Plenary Lecture | International Forum on Hepatitis | 2016 | Cairo, Egypt |
”Autoimmune Hepatitis” | Lecture | Medical Grand Rounds | 2016 | Manchester Memorial Hospital |
”Autoimmune Hepatitis” | Lecture | Medical Grand Rounds | 2016 | Rockville General Hospital |
“Chronic Viral Hepatitis: What is it and why does it matter?” | Lecture | Mini-Medical Program | 2016 | UCONN |
“Serum Liver Tests” | Lecture | University of New England College of Osteopathic Medicine | 2016 | Manchester Memorial Hospital |
“Iron in Health and Disease” | Lecture | UCONN 1st y Medical Students | 2016 | UCONN |
“What Makes a Good Research Project: An Editor's Perspective Faculty of Medicine” | Lecture | Faculty of Medicine, University of Osijek | 2016 | Osijek, Croatia |
“Mentor and Teacher: What’s the Difference?” | Lecture | Faculty of Medicine, University of Osijek | 2016 | Osijek, Croatia |
“The MD-PHD Program: A Personal Experience” | Lecture | Faculty of Medicine, University of Osijek | 2016 | Osijek, Croatia |
“Publication of Medical Articles: Strategies for Success” | Lecture | Faculty of Medicine, University of Osijek | 2016 | Osijek, Croatia |
“Workshop on actual manuscripts” | Lecture | Faculty of Medicine, University of Osijek | 2016 | Osijek, Croatia |
“C. Difficile Colitis and the Gut Microbiome” | Lecture | Medical Grand Rounds | 2016 | Rockville General Hospital |
“Hepatitis A, D, and E” | Lecture | University of New England College of Osteopathic Medicine | 2016 | Manchester Memorial Hospital |
“Introduction of Gastroenterology” “Chronic Viral Hepatitis” “Endoscopy”* | Lecture | UCONN Pre-Med Course | 2016 | UCONN |
“C. difficile Colitis and the Gut Microbiome” | Lecture | Medical Grand Rounds | 2016 | Manchester Memorial Hospital |
“Fulminant Hepatic Failure” | Lecture | University of New England College of Osteopathic Medicine | 2016 | Manchester Hospital |
“Strategies for Publishing Medical Articles in English Journals” | Lecture | JiLin University | 2016 | JiLin, China |
“Targeted Transplantation of Mitochondria to Hepatocytes” | Lecture | JiLin University | 2016 | JiLin, China |
“Malabsorption: Clinical Presentation and Diagnostic Tests” | Lecture | Nutrition Department, Saint Joseph’s University | 2016 | West Hartford, CT |
“Celiac Disease” | Lecture | Nutrition Department, Saint Joseph’s University | 2016 | West Hartford, CT |
“Update on HCV Treatment” | Plenary Lecture | Third Annual International Monothematic Conference on Hepatitis C | 2016 | Orahovica, Croatia |
“Brief Update on HCV Treatment” | Lecture | UCONN HCV Support Group | 2016 | UCONN |
“Non-Alcoholic Liver Disease” | Lecture | Interstate Physicians Medical Association | 2016 | San Antonio, TX |
"Meet the Professor" | Talk | Interstate Physicians Medical Association | 2016 | San Antonio, TX |
“The Molecular and Clinical Bases for Anti-HCV Drug Resistance “ | Lecture | Third Annual International Monothematic Conference on Hepatitis C | 2016 | Orahovica, Croatia |
“Imaging of Hepatic Lesions” | Lecture | Medical Grand Rounds | 2016 | Manchester Memorial Hospital |
“Teachers versus Mentors: What’s the Difference” | Lecture | Mentorship Course Faculty of Medicine, University of Osijek | 2016 | Osijek, Croatia |
“Strategies for Publication of Medical Articles” | Lecture | Mentorship Course Faculty of Medicine, University of Osijek | 2016 | Osijek, Croatia |
“Imaging of Hepatic Lesions” | Lecture | Medical Grand Rounds | 2016 | Rockville General Hospital |
“Pathogenesis and Treatment of Ascites” | Lecture | University of New England College of Osteopathic Medicine | 2015 | Manchester Memorial Hospital |
“Update on the Pathogenesis and Treat- ment of Hemochromatosis” | Lecture | Endocrine Intercity Grand Rounds/UCONN | 2015 | UCONN |
“Update on the Pathogenesis and Treatment of HCV” | Lecture | Advances in Internal Medicine | 2015 | UCONN |
"Methotrexate Hepatotoxicity" | Lecture | Medical Grand Rounds | 2015 | Manchester Memorial Hospital |
"Methotrexate Hepatotoxicity" | Lecture | Medical Grand Rounds | 2015 | Rockville General Hospital |
“A Practical Immunocompetent Animal Model of Hepatitis C Viral Infection” | Lecture | Department of Nutritional Sciences | 2015 | UCONN Storrs, CT |
"Digestive Diseases Mediated by Bacterial Toxins” | Lecture | Medical Microbiology Course | 2015 | Misr International University, Cairo, Egypt |
"Update on the Pathogenesis and Treatment of HCV" | Lecture | Medical Microbiology Course, School of Pharmacy | 2015 | Misr International University, Cairo, Egypt |
“Digestive Diseases Caused by Helminths” | Lecture | Medical Microbiology Course, School of Pharmacy | 2015 | Misr International University, Cairo, Egypt |
“Viral Hepatitis” | Lecture | Medical Microbiology Course, School of Pharmacy | 2015 | Misr International University, Cairo, Egypt |
“Chronic Viral Hepatitis: What is it and why is it important” | Lecture | Mini-Medical Program | 2015 | UCONN |
“Update on the pathogenesis, and treatment of HCV” | Lecture | The 22nd Annual GI Symposium Update on the Management of Common GI, Pancrea | 2015 | Rutgers, Robert Wood Johnson School of Medicine New Brunswick, NJ |
"Wilson’s Disease" | Lecture | Medical Grand Rounds | 2015 | Rockville General Hospital |
“Viral Hepatitis” | Lecture | American Liver Foundation Clinical Treatment Initiative | 2015 | Rushford Treatment Center Middletown, CT |
“Iron in Health and Disease” | Lecture | OS3, 2y Medical Students | 2015 | UCONN |
Targeted Transplantation of Mitochondria to Specific Cell Types” | Lecture | Lunch and Learn, Alexion, Corp. Cheshire, CT | 2015 | Cheshire, CT |
“Update on HBV” | Lecture | GI Fellows Lecture | 2015 | UCONN |
“PEG-tubes” | Lecture | GI Fellows’ Lecture Series | 2015 | UCONN |
Foreign Body Ingestion” | Lecture | Medical Grand Rounds | 2015 | Manchester Memorial Hospital |
”Foreign Body Ingestion” | Lecture | Medical Grand Rounds | 2015 | Rockville General Hospital |
“Update on HCV Treatment” | Lecture | HCV Support Group | 2015 | UCONN |
“Hepatitis C Therapy: Current Status and Future Challenges” | Lecture | Second Annual International Monothematic Conference on Hepatitis C | 2015 | Lug, Croatia |
“Extrahepatic Manifestations of Hepatitis C” | Lecture | Second Annual International Monothematic Conference on Hepatitis C | 2015 | Lug, Croatia |
“Structural Analogs for Inhibition of HCV Replication” | Lecture | Second Annual International Monothematic Conference on Hepatitis C | 2015 | Lug, Croatia |
“What Makes a Good Clinical Research Paper?” An Editor's Perspective” | Lecture | First International Summit on Medical Research and Publication | 2015 | Wuhan, China |
“Rescue of Hepatocytes from Lethal Mitochondrial Damage by Targeted Transplantation of Mitochondria” | Talk | American Association for the Study of Liver Diseases | 2015 | San Francisco, CA |
“Pathogenesis and Treatment of Ascites” | Lecture | University of New England College of Osteopathic Medicine | 2015 | Manchester Memorial Hospital |