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Liping Xiao, M.D., Ph.D.Assistant Professor of Medicine and Psychiatry
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Education
Post-Graduate Training
Awards
Degree | Institution | Major |
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M.D. | Hebei Medical University | Medicine |
Ph.D. | Tianjin Medical University | Endocrinology and Metabolism |
M.Sc. | UConn Health | Clinical Translational Research |
Post-Graduate Training
Training | Institution | Specialty |
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Residency | Tangshan Worker Hospital | Internal Medicine |
Fellowship | Tianjin Medical University | Endocrinology and Metabolism |
Postdoctoral | UConn Health | Endocrinology and Metabolism |
Awards
Name of Award/Honor | Awarding Organization |
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Patent: METHODS OF TREATING SICKLE CELL DISORDER AND RELATED CONDITIONS. | UConn Health |
ASBMR 2019 Mid-Career Faculty Travel Award | American Society for Bone and Mineral Research |
Lawrence G. Raisz Travel Grant Award | UConn Health |
Co-chair at Symposium “Thematic FGF Differences” | ASBMR annual meeting |
Invited speaker | Gordon Research Conference |
The Department of Medicine Scholars Awards | UConn Health |
Lawrence G. Raisz Fund for Musculoskeletal Research & Education ASBMR Travel Award | UConn Health |
Reviewer | Gene |
Reviewer | Cellular Physiology and Biochemistry |
Lawrence G. Raisz Fund for Musculoskeletal Research & Education ASBMR Travel Award | UConn Health |
Recipient | Lawrence G. Raisz Travel Grant Award |
Reviewer | International Journal of Medical and Health Sciences Research |
Reviewer | International Journal of Nanomedicine |
Reviewer | PLOS ONE |
Reviewer | International Journal of Medical and Health Sciences Research |
Recipient | Lawrence G. Raisz Travel Grant Award |
Recipient, Henry Christian Award | American Federation for Medical Research |
Volunteer Interpreter, Commitment Recognition Award | UConn Health |
Web Jee Young Investigator Award, | International Chinese Musculoskeletal Research Society |
Recipient, ICHTS Web Jee Young Investigator Award | International Chinese Hard Tissue Society |
Young Investigator Award | ASBMR annual meeting |
Recipient, Young Investor Award | American Society for Bone and Mineral Research |
Member | International Chinese Society for Bone and Mineral Research |
Federal Scholarship | Tianjin Medical University |
Member | American Society for Bone and Mineral Research |
Not accepting students for Lab Rotations at this time
Journal Articles
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Bone loss is ameliorated by fecal microbiota transplantation through SCFA/GPR41/ IGF1 pathway in sickle cell disease mice.
Scientific reports 2022 Nov;12(1):20638
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FGF receptor inhibitor BGJ398 partially rescues osteoarthritis-like phenotype in older high molecular weight FGF2 transgenic mice via multiple mechanisms.
Scientific reports 2022 Sep;12(1):15968
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Fibroblast Growth Factor 2 High Molecular Weight Isoforms in Dentoalveolar Mineralization.
Calcified tissue international 2021 Jul;
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Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice.
Scientific reports 2021 May;11(1):11005
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Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice
Cartilage 2020 Oct;1947603520962565
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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms.
Endocrinology 2020 Jan;161(1):
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Depletion of Intestinal Microbiome Partially Rescues Bone Loss in Sickle Cell Disease Male Mice.
Scientific reports 2019 Jun;9(1):8659
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Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Journal of cellular physiology 2019 Apr;2344418-4431
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Bone marrow neutrophil aging in sickle cell disease mice is associated with impaired osteoblast functions.
Biochemistry and biophysics reports 2018 Dec;16110-114
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FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation.
Bone reports 2018 Dec;9136-144
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FGF23 regulates Wnt/β-catenin signaling-mediated osteoarthritis in mice overexpressing high molecular weight FGF2.
Endocrinology 2018 Apr;1592386-2396
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FGF23 Neutralizing Antibody Partially Improves Bone Mineralization Defect of HMWFGF2 Isoforms Transgenic Female Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2018 Mar;331347-1361
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Inhibition of FGFR Signaling Partially Rescues Hypophosphatemic Rickets in HMWFGF2 Tg Male Mice.
Endocrinology 2017 Oct;158(10):3629-3646
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Clinically Relevant Concentrations of Ketamine Inhibit Osteoclast Formation In Vitro in Mouse Bone Marrow Cultures.
Journal of cellular biochemistry 2016 Oct;118914-923
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FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.
Endocrinology 2016 Oct;1574602-4614
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FGF23 Neutralizing Antibody Ameliorates Hypophosphatemia and Impaired FGF Receptor Signaling in Kidneys of HMWFGF2 Transgenic Mice.
Journal of cellular physiology 2016 Jun;232610-616
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Loss of Bone in Sickle Cell Trait and Sickle Cell Disease Female Mice Is Associated with Reduced IGF-1 in Bone and Serum.
Endocrinology 2016 May;1573036-46
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FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice.
Journal of cellular biochemistry 2016 Jan;1171991-2000
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Age-Related Changes in FGF-2, Fibroblast Growth Factor Receptors and β-Catenin Expression in Human Mesenchyme-Derived Progenitor Cells.
Journal of cellular biochemistry 2015 Sep;117721-9
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Accelerated Fracture Healing in Transgenic Mice Overexpressing an Anabolic Isoform of Fibroblast Growth Factor 2.
Journal of cellular biochemistry 2015 Aug;117599-611
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Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis.
The Journal of biological chemistry 2014 Nov;289(52):36303-14
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Fibroblast growth factor-2 isoform (low molecular weight/18 kDa) overexpression in preosteoblast cells promotes bone regeneration in critical size calvarial defects in male mice.
Endocrinology 2014 Jan;155(3):965-74
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FGF-2 enhances Runx-2/Smads nuclear localization in BMP-2 canonical signaling in osteoblasts.
Journal of cellular physiology 2013 Nov;228(11):2149-58
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BMP-2 differentially modulates FGF-2 isoform effects in osteoblasts from newborn transgenic mice.
Endocrinology 2013 Aug;154(8):2723-33
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Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Jan;28(1):35-45
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Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway.
The Journal of biological chemistry 2011 Nov;286(47):40575-83
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The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
Biochemical and biophysical research communications 2011 Aug;412(1):160-4
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Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells.
Bone 2010 Aug;47(2):360-70
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Signaling pathways implicated in PGF2alpha effects on Fgf2+/+ and Fgf2-/- osteoblasts.
Journal of cellular physiology 2010 Aug;224(2):465-74
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Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO.
The Journal of biological chemistry 2010 Jan;285(4):2834-46
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Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts.
Biochemical and biophysical research communications 2010 Jan;391(1):335-9
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Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice.
The Journal of biological chemistry 2009 Jan;284(5):3170-82
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Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice.
Journal of cellular biochemistry 2008 Apr;103(6):1975-88
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Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.
Biochemical and biophysical research communications 2006 Mar;341(4):989-94
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Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice.
Journal of cellular biochemistry 2005 May;95(1):83-94
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Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.
The Journal of biological chemistry 2004 Jun;279(26):27743-52
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Effect of overexpressing fibroblast growth factor 2 protein isoforms in osteoblastic ROS 17/2.8 cells.
Journal of cellular biochemistry 2003 Aug;89(6):1291-301
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Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice
Cartilage Oct 3
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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms
Endocrinology Jan 1;161(1)
Abstracts
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Conditional Knockout of Fgf2 in Cartilage Results in Osteoarthritis Development in Mice
JBMR Suppl2021
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Conditional Knockout of FGF2 in Osteocytes Results in Impaired Bone Formation and Increased Osteocytes Apoptosis in Mice
JBMR, Suppl, 2022.
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Fecal Microbiota Transplantation Alleviates Bone Loss in Sickle Cell Disease Mice through Regulating SCFA Medicated IGF1 Production
JBMR Suppl2021
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FGF23 in crosstalk of bone, kidney, and hematopoiesis in sickle cell bone disease
J Bone Miner Res 2019, Suppl
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FGF23 Neutralizing Antibody Rescues Reduced Bone Nodule Formation in Bone Marrow Stromal Cell Cultures from Sickle Cell Disease Mice
J Bone Miner Res 2020, Suppl
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Impaired PTH-stimulated periosteal proliferation, Wnt activity and fracture healing in Fgf2 knockout mice
J Bone Miner Res 2019, Suppl
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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms
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Inhibition of FGFR signaling partially rescues osteoarthritis in mice overexpressing high-molecular-weight FGF2
J Bone Miner Res 2019, Suppl
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Inhibition of TLRs/NF-kB Signaling Pathway through FGFR Blocking Partially Rescues Osteoarthritis in HMWFGF2 Transgenic Mice
JBMR, Suppl, 2022.
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Muscle dysfunction in Female Fibroblast Growth Factor 2 Knockout Mice
J Bone Miner Res 2019, Suppl
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Role of FGF Receptor, FGF23 Signaling in Enthesopathy of Achilles Tendon in High Molecular Weight FGF2 Transgenic Mice
J Bone Miner Res 2020, Suppl
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Systemic Administration of rhPRG4 Ameliorates Anemia and Osteoarthritis in Sickle Cell Disease Mice
JBMR Suppl(2021):2021
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Transplantation of the Gut Microbiota from Healthy Mice Ameliorates Bone Loss in Sickle Cell Disease Recipient Mice
J Bone Miner Res 2020, Suppl
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
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Characterizing Craniofacial and Dentition Phenotype of Sickle Cell Trait Mice | Poster | 2023 | Portland, Oregon, USA | |
FGFR Inhibition Partially Rescues Osteoarthritis in Older Male HMWFGF2 Transgenic Mice via Modulation of IL-1/NF-kB Signaling | Poster | Gordon Research Conference | 2022 | Lucca (Barga), Italy |
Inhibition of TLRs/NF-kB Signaling Pathway through FGFR Blocking Partially Rescues Osteoarthritis in HMWFGF2 Transgenic Mice | Poster | 2022 | ASBMR | |
Conditional Knockout of FGF2 in Osteocytes Results in Impaired Bone Formation and Increased Osteocytes Apoptosis in Mice | Poster | 2022 | ASBMR | |
Fecal Microbiota Transplantation Alleviates Bone Loss in Sickle Cell Disease Mice through Regulating SCFA Medicated IGF1 Production | Talk | ASBMR annual meeting | 2021 | ASBMR |
Systemic Administration of rhPRG4 Ameliorates Anemia and Osteoarthritis in Sickle Cell Disease Mice | Poster | 2021 | ASBMR | |
Conditional Knockout of Fgf2 in Cartilage Results in Osteoarthritis Development in Mice | Poster | 2021 | ASBMR | |
Transplantation of the Gut Microbiota from Healthy Mice Ameliorates Bone Loss in Sickle Cell Disease Recipient Mice (Oral) | Talk | Annual meeting of the American Society for Bone and Mineral Research | 2020 | ASBMR, Virtual |
FGF23 Neutralizing Antibody Rescues Reduced Bone Nodule Formation in Bone Marrow Stromal Cell Cultures from Sickle Cell Disease Mice | Poster | Annual meeting of the American Society for Bone and Mineral Research | 2020 | ASBMR, Virtual |
Role of FGF Signaling in Enthesopathy of Achilles Tendon in High Molecular Weight FGF2 Transgenic Mice | Poster | Rare Disease Day Symposium | 2020 | RDD, North Haven, CT |
Role of FGF Signaling in Enthesopathy of Achilles Tendon in HMWFGF2 Transgenic Mice | Poster | UConn Musculoskeletal Institute Research Day | 2020 | UConn Musculoskeletal Institute Research Day, Farmington, CT |
High Molecular Weight FGF2 in Dentin and Alveolar Bone Mineralization | Poster | Rare Disease Day Symposium | 2020 | RDD, North Haven, CT |
FGF23 in crosstalk of bone, kidney, and hematopoiesis in sickle cell bone disease | Talk | Annual meeting of the American Society for Bone and Mineral Research | 2019 | Orlando, Florida |
Inhibition of FGFR signaling partially rescues osteoarthritis in mice overexpressing high-molecular-weight FGF2 | Talk | Annual meeting of the American Society for Bone and Mineral Research | 2019 | Orlando, Florida |
Impaired PTH-stimulated periosteal proliferation, Wnt activity and fracture healing in Fgf2 knockout mice | Poster | Annual meeting of the American Society for Bone and Mineral Research | 2019 | Orlando, Florida |
Muscle dysfunction in Female Fibroblast Growth Factor 2 Knockout Mice. Annual Meeting of the American Society for Bone & Mineral Research | Poster | Annual meeting of the American Society for Bone and Mineral Research | 2019 | Orlando, Florida |
Investigating the Role of Fibroblast Growth Factor 2 Isoforms in the Development of Alzheimer’s Disease Biomarkers in the Hippocampus of Female Mice | Poster | Partnership for Innovation and Education (PIE) INNOVATION RESEARCH DAY | 2019 | Farmington, CT |
BMP-2 enhances the bone healing effect of low molecular weight fgf-2 on calvarial defects in mice | Talk | American Federation for Medical Research Eastern Regional Meeting | 2013 | Washington, DC |
Effect of valproic acid on huntington’s disease affected human embryonic stem cells | Talk | The Department of Psychiatry Research Bonanza at UCHC | 2013 | Farmington, CT |
Exported 18kDa isoform of fibroblast growth factor-2 improved bone regeneration in critical size mice calvarial defects | Talk | Annual Research Day of the New England Musculoskeletal Institute | 2011 | Farmington, CT, June 2011 |
Targeted overexpression of the nuclear FGF2 isoforms in osteoblasts induces hypophosphatemia via modulation of FGF23 and Klotho in mice | Talk | American Society for Bone and Mineral Research | 2008 | Montreal, Quebec, CANADA |
Effect of overexpression of a FGF2 isoform on bone loss in ovariectomized mice | Talk | Center for Interdisciplinary Research in Women's Health | 2006 | Farmington, CT |
Transgenic mice expressing high molecular weight isoforms of FGF2 exhibit decreased bone mass and disturbed phosphate homeostasis | Talk | ASBMR annual meeting | 2006 | Philadelphia, PA |
The exported 18kDa isoform of FGF2 is a critical determinant of bone mass in mice | Talk | ASBMR annual meeting | 2004 | Seattle, Washington |
26th Annual Meeting of the American Society for Bone and Mineral Research | Lecture | American Society for Bone and Mineral Research | 2004 | Seattle, WA |
The transcription factor STAT-1 is a novel negative regulator of bone mass and bone formation | Talk | ASBMR annual meeting | 2003 | Minneapolis, Minnesota |
Oral Presentation | Lecture | 25th Annual Meeting of the American Society for Bone and Mineral Research | 2003 | Minneapolis, MN |