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Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
Sasmita, Andrew Octavian; Depp, Constanze; Nazarenko, Taisiia; Sun, Ting; Siems, Sophie B; Ong, Erinne Cherisse; Nkeh, Yakum B; Böhler, Carolin; Yu, Xuan; Bues, Bastian; Evangelista, Lisa; Mao, Shuying; Morgado, Barbara; Wu, Zoe; Ruhwedel, Torben; Subramanian, Swati; Börensen, Friederike; Overhoff, Katharina; Spieth, Lena; Berghoff, Stefan A; Sadleir, Katherine Rose; Vassar, Robert; Eggert, Simone; Goebbels, Sandra; Saito, Takashi; Saido, Takaomi; Saher, Gesine; Möbius, Wiebke; Castelo-Branco, Gonçalo; Klafki, Hans-Wolfgang; Wirths, Oliver; Wiltfang, Jens; Jäkel, Sarah; Yan, Riqiang; Nave, Klaus-Armin Nature neuroscience 2024 Sep;27(9):1668-1674
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ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina.
Palko, Sarah I; Benoit, Marc R; Yao, Annie Y; Mohan, Royce; Yan, Riqiang Glia 2024 Jun;72(6):1067-1081
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Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice.
Li, Yong-Xia; Tan, Zhi-Nei; Li, Xu-Hui; Ma, Boyu; Adu Nti, Frank; Lv, Xiao-Qiang; Tian, Zhen-Jun; Yan, Riqiang; Man, Heng-Ye; Ma, Xin-Ming Molecular psychiatry 2024 Mar;
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Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease.
Huang, Hao; Sharoar, Md Golam; Pathoulas, Joseph; Fan, Liangliang; He, Wanxia; Xiang, Rong; Yan, Riqiang Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(4):167086
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Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration.
Hudobenko, Jacob; Gayen, Manoshi; Benoit, Marc R; Singh, Neeraj; Yan, Riqiang Neural regeneration research 2023 Dec;18(12):2667-2668
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Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep-wake Disturbances in AD Mice.
Yao, Annie Y; Halloran, Patrick J; Ge, Yingying; Singh, Neeraj; Zhou, John; Galske, James; He, Wanxia; Yan, Riqiang; Hu, Xiangyou The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Aug;43(35):6197-6211
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Reticulon 1 and 3 are essential for axonal growth and synaptic maintenance associated with the intellectual development.
Zhou, John; Shi, Qi; Ge, Ying Ying; He, Wanxia; Hu, Xiangyou; Xia, Weiming; Yan, Riqiang Human molecular genetics 2023 May;
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BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides.
Zhou, John; Singh, Neeraj; Galske, James; Hudobenko, Jacob; Hu, Xiangyou; Yan, Riqiang Molecular neurodegeneration 2023 May;18(1):31
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Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats.
Tan, Zhinei; Li, Yongxia; Guan, Yinzheng; Iqbal, Javed; Wang, Chenyue; Yan, Riqiang; Ma, Xin-Ming International journal of molecular sciences 2023 Jan;24(2):
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Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation.
Benoit, Marc; Darboe, Mabintou; Das, Brati; Ge, Yingying; Zhou, John; Yao, Annie; He, Wanxia; Yan, Riqiang; Hu, Xiangyou Human molecular genetics 2022 Nov;
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The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling.
Gayen, Manoshi; Benoit, Marc R; Fan, Qingyuan; Hudobenko, Jacob; Yan, Riqiang The Journal of biological chemistry 2022 Sep;298(11):102532
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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance.
Singh, Neeraj; Das, Brati; Zhou, John; Hu, Xiangyou; Yan, Riqiang Science advances 2022 Jul;8(29):eabo3610
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BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1.
Singh, Neeraj; Benoit, Marc R; Zhou, John; Das, Brati; Davila-Velderrain, Jose; Kellis, Manolis; Tsai, Li-Huei; Hu, Xiangyou; Yan, Riqiang Science advances 2022 Jun;8(24):eabo1286
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Alzheimer's disease amyloidogenesis is linked to altered lower urinary tract physiology.
Hardy, Cara C; Ramasamy, Ramalakshmi; Rosenberg, Dawn A; Kuchel, George A; Yan, Riqiang; Hu, Xiangyou; Smith, Phillip P Neurourology and urodynamics 2022 May;
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Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.
Fan, Liang-Liang; Du, Ran; Liu, Ji-Shi; Jin, Jie-Yuan; Wang, Chen-Yu; Dong, Yi; He, Wan-Xia; Yan, Ri-Qiang; Xiang, Rong Experimental & molecular medicine 2022 May;54(5):653-661
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Distinct profiles of cellular senescence-associated gene expression in the aged, diseased or injured central nervous system.
Pijewski, Robert S; Sutter, Pearl A; Duszak, Victoria A; Singh, Neeraj; Yan, Riqiang; Smith, Phillip P; Crocker, Stephen J Neuroscience letters 2022 Feb;772136480
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Evoked Cortical Depolarizations Before and After the Amyloid Plaque Accumulation: Voltage Imaging Study.
Zhu, Mei Hong; Jogdand, Aditi H; Jang, Jinyoung; Nagella, Sai C; Das, Brati; Milosevic, Milena M; Yan, Riqiang; Antic, Srdjan D Journal of Alzheimer's disease : JAD 2022 Jan;88(4):1443-1458
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Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains.
Sharoar, Md Golam; Zhou, John; Benoit, Marc; He, Wanxia; Yan, Riqiang Neurobiology of aging 2021 Nov;10721-29
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Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains.
Sharoar, Md Golam; Palko, Sarah; Ge, Yingying; Saido, Takaomi C; Yan, Riqiang Molecular neurodegeneration 2021 Jul;16(1):45
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BACE1 controls synaptic function through modulating release of synaptic vesicles.
Das, Brati; Singh, Neeraj; Yao, Annie Y; Zhou, John; He, Wanxia; Hu, Xiangyou; Yan, Riqiang Molecular psychiatry 2021 Jun;
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Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity.
Yao, Annie Y; Yan, Riqiang Molecular neurodegeneration 2020 Nov;15(1):69
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β-Secretase1 biological markers for Alzheimer's disease: state-of-art of validation and qualification.
Hampel, Harald; Lista, Simone; Vanmechelen, Eugeen; Zetterberg, Henrik; Giorgi, Filippo Sean; Galgani, Alessandro; Blennow, Kaj; Caraci, Filippo; Das, Brati; Yan, Riqiang; Vergallo, Andrea; Alzheimer’s Precision Medicine Initiative (APMI) Alzheimer's research & therapy 2020 Oct;12(1):130
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The β-Secretase BACE1 in Alzheimer's Disease.
Hampel, Harald; Vassar, Robert; De Strooper, Bart; Hardy, John; Willem, Michael; Singh, Neeraj; Zhou, John; Yan, Riqiang; Vanmechelen, Eugeen; De Vos, Ann; Nisticò, Robert; Corbo, Massimo; Imbimbo, Bruno Pietro; Streffer, Johannes; Voytyuk, Iryna; Timmers, Maarten; Tahami Monfared, Amir Abbas; Irizarry, Michael; Albala, Bruce; Koyama, Akihiko; Watanabe, Naoto; Kimura, Teiji; Yarenis, Lisa; Lista, Simone; Kramer, Lynn; Vergallo, Andrea Biological psychiatry 2020 Feb;
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Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future.
Srivastava, Akriti; Das, Brati; Yao, Annie Y; Yan, Riqiang Journal of Alzheimer's disease : JAD 2020 Jan;78(4):1345-1361
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Activated CX3CL1/Smad2 signals prevent neuronal loss and Alzheimer's tau pathology-mediated cognitive dysfunction.
Fan, Qingyuan; He, Wanxia; Gayen, Manoshi; Robert Benoit, Marc; Luo, Xiaoyang; Hu, Xiangyou; Yan, Riqiang The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Dec;
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CX3CL1 intracellular domain and adult neurogenesis.
Benoit, Marc R; Gayen, Manoshi; Yan, Riqiang Aging 2019 Nov;11(23):10783-10785
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Dystrophic neurites labelled by pre-autophagosomal proteins in Alzheimer's brains.
Sharoar, Md Golam; Hu, Xiangyou; Ma, Xin-Ming; Zhu, Xiongwei; Yan, Riqiang Molecular psychiatry 2019 Sep;24(9):1247
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The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology.
Fan, Qingyuan; Gayen, Manoshi; Singh, Neeraj; Gao, Fan; He, Wanxia; Hu, Xiangyou; Tsai, Li-Huei; Yan, Riqiang The Journal of experimental medicine 2019 Jun;
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Sequential formation of different layers of dystrophic neurites in Alzheimer's brains.
Sharoar, Md Golam; Hu, Xiangyou; Ma, Xin-Ming; Zhu, Xiongwei; Yan, Riqiang Molecular psychiatry 2019 Mar;24(9):1369-1382
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A Close Look at BACE1 Inhibitors for Alzheimer's Disease Treatment.
Das, Brati; Yan, Riqiang CNS drugs 2019 Mar;33(3):251-263
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The sterol regulatory element-binding protein 2 is likely dysregulated by tau alterations in Alzheimer disease.
Wang, Chunyu; Zhao, Fanpeng; Shen, Katie; Wang, Wenzhang; Siedlak, Sandra L; Lee, Hyoung-Gon; Phelix, Clyde F; Perry, George; Shen, Lu; Tang, Beisha; Yan, Riqiang; Zhu, Xiongwei Brain pathology (Zurich, Switzerland) 2018 Dec;
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Elevated cleavage of neuregulin-1 by beta-secretase 1 in plasma of schizophrenia patients.
Zhang, Zhengrong; Cui, Jie; Gao, Feng; Li, Yuhong; Zhang, Guofu; Liu, Min; Yan, Riqiang; Shen, Yong; Li, Rena Progress in neuro-psychopharmacology & biological psychiatry 2018 Nov;90161-168
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Increased Reticulon 3 (RTN3) Leads to Obesity and Hypertriglyceridemia by Interacting With Heat Shock Protein Family A (Hsp70) Member 5 (HSPA5).
Xiang, Rong; Fan, Liang-Liang; Huang, Hao; Chen, Ya-Qin; He, Wanxia; Guo, Shuai; Li, Jing-Jing; Jin, Jie-Yuan; Du, Ran; Yan, Riqiang; Xia, Kun Circulation 2018 Oct;138(17):1828-1838
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BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions.
Hu, Xiangyou; Das, Brati; Hou, Hailong; He, Wanxia; Yan, Riqiang The Journal of experimental medicine 2018 Mar;215(3):927-940
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Identification of rare RTN3 variants in Alzheimer's disease in Han Chinese.
Zou, Yongyi; He, Wanxia; Wang, Kangli; Han, Hailong; Xiao, Tingting; Chen, Xumeng; Zhou, Bin; Tan, Jieqiong; Xia, Kun; Tang, Beisha; Chen, Chao; Shen, Lu; Yan, Riqiang; Zhang, Zhuohua Human genetics 2018 Feb;137141-150
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RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains.
Shi, Qi; Ge, Yingying; He, Wanxia; Hu, Xiangyou; Yan, Riqiang Scientific reports 2017 Jul;7(1):6145
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BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus.
Hou, Hailong; Fan, Qingyuan; He, Wanxia; Suh, Hoonkyo; Hu, Xiangyou; Yan, Riqiang Stem cell reports 2017 Jul;9(1):217-230
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Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy.
Grumati, Paolo; Morozzi, Giulio; Hölper, Soraya; Mari, Muriel; Harwardt, Marie-Lena Ie; Yan, Riqiang; Müller, Stefan; Reggiori, Fulvio; Heilemann, Mike; Dikic, Ivan eLife 2017 Jun;6
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BACE1 regulates the proliferation and cellular functions of Schwann cells.
Hu, Xiangyou; Hou, Hailong; Bastian, Chinthasagar; He, Wanxia; Qiu, Shupeng; Ge, Yingying; Yin, Xinhua; Kidd, Grahame J; Brunet, Sylvain; Trapp, Bruce D; Baltan, Selva; Yan, Riqiang Glia 2017 May;65(5):712-726
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Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.
Sharoar, M G; Shi, Q; Ge, Y; He, W; Hu, X; Perry, G; Zhu, X; Yan, R Molecular psychiatry 2016 Sep;21(9):1263-71
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Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.
Yan, Riqiang; Fan, Qingyuan; Zhou, John; Vassar, Robert Neuroscience and biobehavioral reviews 2016 Jun;65326-40
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Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.
Hu, Xiangyou; Fan, Qingyuan; Hou, Hailong; Yan, Riqiang Journal of neurochemistry 2016 Jan;136(2):234-49
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Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs.
Yan, Riqiang Translational neurodegeneration 2016 Jan;513
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Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.
Hu, Xiangyou; Hu, Jinxuan; Dai, Lu; Trapp, Bruce; Yan, Riqiang The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Mar;35(9):3806-14
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Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition.
Shi, Qi; Ge, Yingying; Sharoar, Md Golam; He, Wanxia; Xiang, Rong; Zhang, Zhuohua; Hu, Xiangyou; Yan, Riqiang The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Oct;34(42):13954-62
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β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.
He, Wanxia; Hu, Jinxuan; Xia, Yuxing; Yan, Riqiang The Journal of biological chemistry 2014 Jul;289(30):20630-7
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Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.
Luo, Xiaoyang; He, Wanxia; Hu, Xiangyou; Yan, Riqiang Biological psychiatry 2014 Jul;76(2):120-7
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Targeting the β secretase BACE1 for Alzheimer's disease therapy.
Yan, Riqiang; Vassar, Robert The Lancet. Neurology 2014 Mar;13(3):319-29
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Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.
Deng, Minzi; He, Wanxia; Tan, Ya; Han, Hailong; Hu, Xiangyou; Xia, Kun; Zhang, Zhuohua; Yan, Riqiang The Journal of biological chemistry 2013 Oct;288(42):30236-45
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BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway.
Hu, Xiangyou; He, Wanxia; Luo, Xiaoyang; Tsubota, Katherine Elyse; Yan, Riqiang Cell reports 2013 Jul;4(1):40-9
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Diabetes-induced central neuritic dystrophy and cognitive deficits are associated with the formation of oligomeric reticulon-3 via oxidative stress.
Zhao, Bei; Pan, Bai-Shen; Shen, Su-Wen; Sun, Xiao; Hou, Zheng-Zhou; Yan, Riqiang; Sun, Feng-Yan The Journal of biological chemistry 2013 May;288(22):15590-9
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Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression.
Hu, Xiangyou; Schlanger, Rita; He, Wanxia; Macklin, Wendy B; Yan, Riqiang FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 May;27(5):1868-73
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Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice.
Shi, Qi; Prior, Marguerite; Zhou, Xiangdong; Tang, Xiaoying; He, Wanxia; Hu, Xiangyou; Yan, Riqiang The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Feb;33(7):3059-66
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VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.
Wen, Lei; Tang, Fu-Lei; Hong, Yan; Luo, Shi-Wen; Wang, Chun-Lei; He, Wanxia; Shen, Chengyong; Jung, Ji-Ung; Xiong, Fei; Lee, Dae-hoon; Zhang, Quan-Guang; Brann, Darrell; Kim, Tae-Wan; Yan, Riqiang; Mei, Lin; Xiong, Wen-Cheng The Journal of cell biology 2011 Nov;195(5):765-79
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Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition.
Zhou, Xiangdong; Hu, Xiangyou; He, Wanxia; Tang, Xiaoying; Shi, Qi; Zhang, Zhuohua; Yan, Riqiang FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Sep;25(9):3146-56
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Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination.
Luo, Xiaoyang; Prior, Marguerite; He, Wanxia; Hu, Xiangyou; Tang, Xiaoying; Shen, Weizhen; Yadav, Satya; Kiryu-Seo, Sumiko; Miller, Robert; Trapp, Bruce D; Yan, Riqiang The Journal of biological chemistry 2011 Jul;286(27):23967-74
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APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner.
Cui, Shun; Xiong, Fei; Hong, Yan; Jung, Ji-Ung; Li, Xing-Sheng; Liu, Jian-Zhong; Yan, Riqiang; Mei, Lin; Feng, Xu; Xiong, Wen-Cheng Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 May;26(5):1084-98
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Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Heath, Jonathon E; Siedlak, Sandra L; Zhu, Xiongwei; Lee, Hyoung-Gon; Thakur, Akanksha; Yan, Riqiang; Perry, George; Smith, Mark A; Castellani, Rudy J Neuropathology : official journal of the Japanese Society of Neuropathology 2010 Dec;30(6):574-9
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Inhibition of BACE1 for therapeutic use in Alzheimer's disease.
Luo, Xiaoyang; Yan, Riqiang International journal of clinical and experimental pathology 2010 Jul;3(6):618-28
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RTN/Nogo in forming Alzheimer's neuritic plaques.
Prior, Marguerite; Shi, Qi; Hu, Xiangyou; He, Wanxia; Levey, Allan; Yan, Riqiang Neuroscience and biobehavioral reviews 2010 Jul;34(8):1201-6
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BACE1 deficiency causes altered neuronal activity and neurodegeneration.
Hu, Xiangyou; Zhou, Xiangdong; He, Wanxia; Yang, Jun; Xiong, Wencheng; Wong, Philip; Wilson, Christopher G; Yan, Riqiang The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jun;30(26):8819-29
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Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.
Zhang, Yong; Xiong, Man; Yan, Ri-Qiang; Sun, Feng-Yan Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010 Mar;30(3):566-75
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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.
Vassar, Robert; Kovacs, Dora M; Yan, Riqiang; Wong, Philip C The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Oct;29(41):12787-94
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CHI's Eighth Annual World Pharmaceutical Congress. Targeting Alzheimer's with novel therapeutics: Part 2.
Yan, Riqiang IDrugs : the investigational drugs journal 2009 Aug;12(8):482-4
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Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites.
Shi, Qi; Prior, Marguerite; He, Wanxia; Tang, Xiangying; Hu, Xiangyou; Yan, Riqiang The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jul;29(29):9163-73
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The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function.
Shi, Qi; Hu, Xiangyou; Prior, Marguerite; Yan, Riqiang The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Apr;29(16):5108-15
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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves.
Hu, Xiangyou; He, Wanxia; Diaconu, Claudiu; Tang, Xiaoying; Kidd, Grahame J; Macklin, Wendy B; Trapp, Bruce D; Yan, Riqiang FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Aug;22(8):2970-80
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Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1.
Carter, Donald B; Dunn, Edwige; Pauley, Adele M; McKinley, Denise D; Fleck, Timothy J; Ellerbrook, Brenda R; Stratman, Nancy C; Zhou, Xiangdong; Himes, Carol S; Nye, Jeffrey S; Tomasselli, Alfredo; Yan, Riqiang Molecular neurodegeneration 2008 May;36
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Homogeneity of active demyelinating lesions in established multiple sclerosis.
Breij, Esther C W; Brink, Bianca P; Veerhuis, Rob; van den Berg, Christa; Vloet, Rianka; Yan, Riqiang; Dijkstra, Christine D; van der Valk, Paul; Bö, Lars Annals of neurology 2008 Jan;63(1):16-25
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NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in A beta PP-overexpressing cultured human muscle fibers.
Wojcik, Slawomir; Engel, W King; Yan, Riqiang; McFerrin, Janis; Askanas, Valerie Acta neuropathologica 2007 Nov;114(5):517-26
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The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1.
He, Wanxia; Shi, Qi; Hu, Xiangyou; Yan, Riqiang The Journal of biological chemistry 2007 Oct;282(40):29144-51
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Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities.
Hu, Xiangyou; Shi, Qi; Zhou, Xiangdong; He, Wanxia; Yi, Hong; Yin, Xinghua; Gearing, Marla; Levey, Allan; Yan, Riqiang The EMBO journal 2007 Jun;26(11):2755-67
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Bace1 modulates myelination in the central and peripheral nervous system.
Hu, Xiangyou; Hicks, Caitlin W; He, Wanxia; Wong, Philip; Macklin, Wendy B; Trapp, Bruce D; Yan, Riqiang Nature neuroscience 2006 Dec;9(12):1520-5
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Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins.
He, Wanxia; Hu, Xiangyou; Shi, Qi; Zhou, Xiangdong; Lu, Yifeng; Fisher, Christopher; Yan, Riqiang Journal of molecular biology 2006 Oct;363(3):625-34
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Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1.
Qahwash, Isam; He, Wanxia; Tomasselli, Alfredo; Kletzien, Rolf F; Yan, Riqiang The Journal of biological chemistry 2004 Sep;279(37):39010-6
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Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.
He, Wanxia; Lu, Yifeng; Qahwash, Isam; Hu, Xiang-You; Chang, Ansi; Yan, Riqiang Nature medicine 2004 Sep;10(9):959-65
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Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice
Li, Yong-Xia; Tan, Zhi-Nei; Li, Xu-Hui; Ma, Bo-Yu; Adu Nti, Frank; Lu, Xiao-qiang; Tian, Zhen-Jun; Yan, Riqiang; Man, Heng-Ye; Ma, Xin-Ming Molecular Psychiatry
