|
Ming Yang, DVM, PhDAssistant Professor of Surgery
|
|||||
To uncover the cellular and molecular mechanisms of chronic liver diseases, including non-alcoholic steatohepatitis (NASH), liver fibrosis, and hepatocellular carcinoma (HCC).
To study NASH-associated metabolic disorders such as cardiovascular disease.
To screen the key factors associated with metabolic liver disease and find potential therapeutic targets.
To improve the clinical diagnosis of liver and pancreatic diseases and develop new therapies for the treatment of these disease such as CAR-NK cells.
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| PhD | University of Missouri | Pathobiology and Microbiology |
| MSc | Beijing University of Agriculture | Pharmacology |
| DVM | Agriculture University of Hebei | Veterinary Medicine |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | University of Missouri | Postdoctoral Fellow at Surgery |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Best Presentation Award | Ellis Fischel Cancer Center |
| Distinguished Speaker | GLOBAL Congress on Advances in Gastroenterology & Hepatology |
| Best Presentation Award | Society of Chinese Bioscientists in America (SCBA)-Hepatology Division |
| Keystone Symposia Scholarship | Keystone Symposia |
| Postdoctoral research grant | Society of Chinese Bioscientists in America (SCBA)-Hepatology Division |
| Postdoctoral research grant | University of Missouri |
| Third place in Resident/Grad Student Poster Award | Phi Zeta Society |
| Mizzou Advantage Travel Grant | University of Missouri |
| Second place in Resident/Grad Student Poster Award | Phi Zeta Society |
| Visiting Scholarship | Mississippi State University |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| American Association for Cancer Research (AACR) | Professional/Scientific Organization | Member | External | National | 2023 | |
| Frontiers in Medicine | Professional/Scientific Journal | Editorial Reviewer | External | International | 2022 | |
| American Association for the Advancement of Science | Professional/Scientific Organization | Member | External | National | 2015 | |
| American Society of Microbiology | Professional/Scientific Organization | Member | External | National | 2015 | |
| American Society of Microbiology | Professional/Scientific Organization | Member | External | National | 2015 |
My research focuses on the cellular and molecular mechanisms of the transition of metabolic dysfunction-associated steatotic liver disease to nonalcoholic steatohepatitis, liver fibrosis, and hepatocellular carcinoma, as well as associated metabolic diseases such as obesity and cardiovascular disease. Aim to screen the key factors associated with metabolic liver disease and find potential therapeutic targets and to improve the clinical diagnosis of liver and pancreatic diseases and develop new therapies for the treatment of these disease such as CAR-T/NK cells.
Journal Articles
-
Bioinformatic Analysis and Computer-Aided Study to Investigate the Potential Application of a Bioflavonoid Compound Bilobetin in Liver Cancer Treatment.
Frontiers in bioscience (Landmark edition) 2023 Dec;28(12):360
-
In silico drug repurposing carvedilol and its metabolites against SARS-CoV-2 infection using molecular docking and molecular dynamic simulation approaches.
Scientific reports 2023 Dec;13(1):21404
-
A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance.
Cancer letters 2023 Dec;578216457
-
Anti-Viral Activity of Bioactive Molecules of Silymarin against COVID-19 via In Silico Studies.
Pharmaceuticals (Basel, Switzerland) 2023 Oct;16(10):
-
Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol.
Nature communications 2023 Jan;14(1):228
-
Astaxanthin Prevents Diet-Induced NASH Progression by Shaping Intrahepatic Immunity.
International journal of molecular sciences 2021 Oct;22(20):
-
Synergizing sunitinib and radiofrequency ablation to treat hepatocellular cancer by triggering the antitumor immune response.
Journal for immunotherapy of cancer 2020 Oct;8(2):
-
Antimicrobial efficacy and toxicity of novel CAMPs against P. aeruginosa infection in a murine skin wound infection model.
BMC microbiology 2019 Dec;19(1):293
-
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria.
BMC microbiology 2018 Jun;18(1):54
-
Demonstration of the bactericidal effects of the boron neutron capture reaction
Applied Radiation and Isotopes 2018 Apr;137190-193
-
Differentiation of Corynebacterium uropygiale strains from Northern Bobwhite (Colinus virginianus) and Turkeys (Meleagris gallopavo)
Poultry, Fisheries & Wildlife Sciences 2017 Nov;5(2):1000186
-
Novel synthetic analogues of avian β-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions.
BMC microbiology 2017 Feb;17(1):43
-
Lactobacillus colini sp. nov., isolated from Northern Bobwhite (Colinus virginianus)
International Journal of Systematic and Evolutionary Microbiology 2017 Feb;67(2):325-329
-
Structure-function analysis of Avian β-defensin-6 and β-defensin-12: role of charge and disulfide bridges.
BMC microbiology 2016 Sep;16(1):210
-
Inhibition of porcine reproductive and respiratory syndrome virus in vitro by forsythoside A
International Journal of Pharmacology 2015 Mar;4394-399.
-
Salmonella enterica serovar enteritidis antimicrobial peptide resistance genes aid in defense against chicken innate immunity, fecal shedding, and egg deposition.
Infection and immunity 2014 Dec;82(12):5185-202
-
Expression, Purification, and In Vitro Comparative Characterization of Avian Beta-Defensin-2, -6, and -12
Avian Diseases 2014 Aug;58(4):541-549.
Book Chapters
-
Hepatocellular Carcinoma and Obesity, Type 2 Diabetes Mellitus, Cardiovascular Disease: Causing Factors, Molecular Links, and Treatment Options.
Frontiers in endocrinology 2021 Jan;808526
-
Targeting T Cell Subtypes for NAFLD and NAFLD-Related HCC Treatment: An Opinion.
Frontiers in medicine 2021 Jan;789859
-
The Potential Gut Microbiota-Mediated Treatment Options for Liver Cancer.
Frontiers in oncology 2020 Jan;524205
Editorials
-
Interleukins in liver disease treatment.
World journal of hepatology 2024 Feb;16(2):140-145
Letters
-
Anti-oxidative stress treatment and current clinical trials.
World journal of hepatology 2024 Feb;16(2):294-299
Reviews
-
Driver Mutations in Pancreatic Cancer and Opportunities for Targeted Therapy.
Cancers 2024 May;16(10):
-
Targeted Therapy for Highly Desmoplastic and Immunosuppressive Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma
2024 Apr;16(8):1470
-
Targeted Therapy for Highly Desmoplastic and Immunosuppressive Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma.
Cancers 2024 Apr;16(8):
-
In vitro and in vivo experimental models for cancer immunotherapy study
Current Research in Biotechnology 2024 Apr;
-
Roles of fibroblast growth factors in the treatment of diabetes.
World journal of diabetes 2024 Mar;15(3):392-402
-
The Roles of Myeloid-Derived Suppressor Cells in Liver Disease.
Biomedicines 2024 Jan;12(2):
-
Gut microbiota and metabolite interface-mediated hepatic inflammation.
Immunometabolism (Cobham, Surrey) 2024 Jan;6(1):e00037
-
Treatment of liver fibrosis: Past, current, and future.
World journal of hepatology 2023 Jun;15(6):755-774
-
The Important Roles of Natural Killer Cells in Liver Fibrosis.
Biomedicines 2023 May;11(5):
-
Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy.
World journal of hepatology 2023 Feb;15(2):180-200
-
Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options.
World journal of gastroenterology 2022 Dec;28(48):6827-6845
-
The Related Metabolic Diseases and Treatments of Obesity.
Healthcare (Basel, Switzerland) 2022 Aug;10(9):
-
Diet and Gut Microbiota Interaction-Derived Metabolites and Intrahepatic Immune Response in NAFLD Development and Treatment.
Biomedicines 2021 Dec;9(12):
-
Diagnostic biomarkers for pancreatic cancer: An update.
World journal of gastroenterology 2021 Dec;27(45):7862-7865
-
Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms.
Frontiers in immunology 2021 Jan;12620510
-
Gut microbiota mediated molecular events and therapy in liver diseases.
World journal of gastroenterology 2020 Dec;26(48):7603-7618
-
The Role and Potential Application of Antimicrobial Peptides in Autoimmune Diseases.
Frontiers in immunology 2020 Jan;11859
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| The important role of regulatory T cells in NASH-mediated HCC development | Poster | 2023 | ||
| Astaxanthin prevents diet-induced NASH progression by shaping intrahepatic immunity | Talk | 2022 | ||
| Impact of gut microbiota on hepatic metabolism and NASH development | Talk | 2022 | ||
| Overexpression of TGFBI promotes the activation of HSCs and NASH progression | Talk | 2021 | ||
| Gut microbiota impacts liver fibrosis by regulating hepatic immunity and inflammation | Talk | 2020 | ||
| Selective modulation of gut microbiota suppresses liver fibrosis by regulating intrahepatic immunity | Poster | 2019 | ||
| LSECs mediate the effect of antibiotic treatment on liver fibrosis through intrahepatic immune responses | Poster | 2019 | ||
| 2-OG mediated activation of hepatic stellate cell and hepatic fibrogenesis | Poster | 2019 | ||
| Novel synthetic avian ß-defensin-12 analogues with enhanced biological functions | Talk | Phi Zeta Society | 2017 | |
| Serovar Distribution and Antimicrobial Susceptibility of Salmonella enterica Isolates from Equine Samples Between 2010 and 2017 | Poster | 2017 | ||
| Serovar Distribution and Antimicrobial Susceptibility of Salmonella enterica Isolates from Avian Samples between 2010 and 2016 | Poster | 2017 | ||
| Novel synthetic analogues of avian ß-defensin-12 with enhanced antimicrobial and immunomodulatory activities | Poster | Missouri Branches of the American Society for Microbiology | 2016 | |
| Modification of natural avian ß-defensin-12 for designing new antimicrobial agents | Poster | University of Missouri | 2016 | |
| Characterization of functional activities of avian-ß-Defensin 6 and 12 | Poster | Phi Zeta Society | 2015 | |
| Characterization of antimicrobial and immunomodulatory activities of avian-ß-defensin 6 and 12 | Poster | Missouri Branches of the American Society for Microbiology | 2015 |