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Daniel W. Youngstrom, Ph.D.Assistant Professor of Orthopedic SurgeryDirector, X-Ray Microtomography (µCT) Core Facility
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- Overview
- Education & Training
- Committees & Organizations
- Research Opportunities
- Lab Rotations
- Publications
My laboratory is primarily interested in translational and evolutionary cell biology of fracture healing.
We are currently using molecular/genetic and surgical techniques in zebrafish, as well as vertebrate cell culture models, to understand the mechanisms of post-developmental osteochondral differentiation by Notch signaling and other stem cell regulatory pathways.
Our goal is to restore form, function and quality of life following musculoskeletal trauma.
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| BS | University of Michigan | Biophysics |
| PhD | Virginia Tech | Biomedical and Veterinary Sciences |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | Michigan State University | Orthopaedics |
| Postdoctoral | University of Michigan | Orthopaedics |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Journal of Orthopaedic Research Early-Career Award (2020) | Orthopaedic Research Society |
| John Haddad Young Investigator Award (2020) | ASBMR Advances in Mineral Metabolism |
| New Investigator Recognition Award (2017) | Orthopaedic Research Society |
| Collaborative Exchange Grant (2017-2018) | Orthopaedic Research Society |
| Ruth L. Kirschstein Individual Postdoctoral NRSA (NIH F32) (2016-2019) | National Institute of Dental and Craniofacial Research |
| Storm Cat Career Development Award (2013) | Grayson-Jockey Club Research Foundation |
| Fulbright U.S. Student Program: Riga, Latvia (2013-2014) | U.S. Department of State |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| ASBMR Advances in Mineral Metabolism | Professional/Scientific Organization | Member | External | International | 2020 | |
| UConn Health Skeletal Biology and Regeneration (SBR) Program | Education Committee | Chair, Recruitment Committee | UConn Health | University | 2020 | |
| Zebrafish Disease Models Society (ZDMS) | Professional/Scientific Organization | Member | External | International | 2019 | |
| UConn Health Graduate School Admissions Committee | Education Committee | PhD Admissions Committee, SBR Representative | UConn Health | University | 2019 | |
| ORS International Section of Fracture Repair (ISFR) | Professional/Scientific Organization | Communications Committee Chair | External | International | 2017 | |
| American Society for Bone and Mineral Research (ASBMR) | Professional/Scientific Organization | Publications Committee Member (ex-officio) | External | International | 2015 | |
| Orthopaedic Research Society (ORS) | Professional/Scientific Organization | Member | External | International | 2015 |
Please contact Dr. Youngstrom directly to discuss opportunities at all levels. Motivated undergraduate thesis students from UConn and other regional institutions are particularly encouraged to apply.
Not accepting rotation students at this time.
Journal Articles
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Vertebral pattern and morphology is determined during embryonic segmentation.
Developmental dynamics : an official publication of the American Association of Anatomists 2023 Sep;
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Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing.
Bone 2023 Jan;169116681
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Functional replacement of myostatin with GDF-11 in the germline of mice.
Skeletal muscle 2022 Mar;12(1):7
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Notch signaling enhances bone regeneration in the zebrafish mandible.
Development (Cambridge, England) 2022 Mar;149(5):
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Local versus systemic control of bone and skeletal muscle mass by components of the transforming growth factor-β signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug;118(33):
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miR-433-3p suppresses bone formation and mRNAs critical for osteoblast function in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 May;
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Silver-doped bioactive glass particles for in vivo bone tissue regeneration and enhanced methicillin-resistant Staphylococcus aureus (MRSA) inhibition.
Materials science & engineering. C, Materials for biological applications 2021 Jan;120111693
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Functional redundancy of type I and type II receptors in the regulation of skeletal muscle growth by myostatin and activin A.
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec;117(49):30907-30917
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Skeletal Screening IMPC/KOMP using μCT and Computer Automated Cryohistology: Application to the Efna4 KO mouse line.
Bone 2020 Oct;115688
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Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight.
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep;117(38):23942-23951
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CTRP3 regulates endochondral ossification and bone remodeling during fracture healing
Journal of Orthopaedic Research 2019 Dec;
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Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects
NPJ Regenerative Medicine 2017 Jan;232
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Jagged-1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in mice
Bone 2016 Oct;9164-74
Reviews
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Genetically engineered zebrafish as models of skeletal development and regeneration.
Bone 2022 Nov;167116611
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Contextual regulation of skeletal physiology by Notch signaling
Current Osteoporosis Reports 2019 Aug;17(4):217-225