Photo of Dong  Zhou, M.D., Ph.D.

Dong Zhou, M.D., Ph.D.

Assistant Professor of Medicine
Academic Office Location:
UConn Health
263 Farmington Avenue
Farmington, CT 06030-1405
Phone: 860-679-3254
M.D.Nanjing University of Chinese MedicineMedicine (Nephrology)
Ph.D.Nanjing University of Chinese Medicine (Joint with University of Pittsburgh)Renal Pathology

Post-Graduate Training
ResidencyAffiliated Hospital of Nanjing University of Chinese MedicineInternal Medicine
PostdoctoralUniversity of PittsburghExperimental Pathology
FellowshipUniversity of PittsburghHealth Science Research Fellow

Name of Award/HonorAwarding Organization
2021 CASN Young Investigator AwardCASN
Travel Grant: Control of Renal Function in Health and Disease ConferenceAPS/ASN
Travel Grant: Kidney Precision Medicine Project Steering Committee meetingKidney Precision Medicine Project
Career Development AwardNIH
Travel Grant: Kidney Week at San DiegoUniversity of Pittsburgh
Travel Grant: Advances in Research ConferenceASN
Pitt Pathology Postdoctoral Research Training AwardUniversity of Pittsburgh
Top Oral Presentation in the Kidney WeekASN
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
NIH Special Emphasis Panel ZDK1 GRB-J M2Study SectionReviewerExternalNational2023
NIH Special Emphasis Panel ZRG1 KUDS Y-(05)Study SectionReviewerExternalNational20232023
NIH Special Emphasis Panel ZRG1 KUDS W-(04)Study SectionReviewerExternalNational20232023
NIH DDK-B Study SectionStudy SectionReviewerExternalNational2022
Journal of Clinical MedicineEditorial BoardMemberExternalInternational2022
NIH PBKD Study SectionStudy SectionReviewerExternalNational20212021
Frontiers in MedicineProfessional/Scientific JournalGuest EditorExternalInternational2021
Queen’s Medical CenterStudy SectionGrant ReviewerExternalInternational2018
American Heart AssociationProfessional/Scientific OrganizationRegular MemberExternalNational2012
American Society of NephrologyProfessional/Scientific OrganizationRegular MemberExternalNational2011

The major research interest in my laboratory is to explore the mechanisms of the transition from acute kidney injury (AKI) to chronic kidney diseases (CKD). We are researching in the following areas:

1. In AKI, we will determine how activated kidney fibroblasts communicate with other resident cells and how a positive kidney local microenvironment is created to dictate the fate of the kidney. By integrating multidisciplinary approaches includes experimental pathology, bioinformatics, and mathematic models, we will construct an early warning system to monitor the onset and progression of AKI. 

2. In CKD, we will determine the existence of the  "transition window" after various kidney injuries and to develop novel therapeutic strategies. 

Accepting Lab Rotation Students: Summer '21, Fall '21, Spring '22

Journal Articles



Title or AbstractTypeSponsor/EventDate/YearLocation
Fibroblasts in Acute Kidney InjuryTalk2nd Joint Nutritional Sciences, Metabolism, and Immunology Symposium2022UCONN Storrs
Tissue Microenvironment in Kidney DiseaseTalkCASN Kidney Day2021In Virtual
The central roles of fibroblast in AKITalkUniversity of Virginia2019Charlottesville, VA
Metabolomics Reveals Signature of Diabetic Kidney DiseasePanel DiscussionAPS/ASN Joint meeting2019Charlottesville, VA
Imperfect adaptive response to acute kidney injury dictates the long-term renal outcomePosterKidney Precision Medicine Project Steering Committee meeting2019Bethesda, MD
Sonic Hedgehog Links Podocyte Injury to Mesangial Cell Activation in Glomerular DiseasePanel DiscussionASN annual meeting2016Chicago, IL
Ablation of Podocyte-derived Wnts Aggravates Proteinuria and Kidney InjuryPanel DiscussionASN annual meeting2015San Diego, CA
Early Activation of Fibroblasts Is Required for Renal Protection and Regeneration After Acute Kidney InjuryPanel DiscussionASN annual meeting2015San Diego, CA
Tubule-derived Wnts are indispensable for fibroblast activation and kidney fibrosisPanel DiscussionASN annual meeting2014Philadelphia, PA
Fibroblast-specific ß-catenin signaling dictates tubular injury and repair after acute kidney injuryPanel DiscussionASN annual meeting2014Philadelphia, PA
Tubular ß-Catenin Signaling Controls Interstitial Fibroblast Fate Via Epithelial-Mesenchymal CommunicationPanel DiscussionASN annual meeting2012San Diego, CA