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Borrelia PeptideAtlas: A proteome resource of common Borrelia burgdorferi isolates for Lyme research.
Reddy, Panga J; Sun, Zhi; Wippel, Helisa H; Baxter, David H; Swearingen, Kristian; Shteynberg, David D; Midha, Mukul K; Caimano, Melissa J; Strle, Klemen; Choi, Yongwook; Chan, Agnes P; Schork, Nicholas J; Varela-Stokes, Andrea S; Moritz, Robert L Scientific data 2024 Dec;11(1):1313
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Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research.
Delgado, Kristina N; Vicente, Crystal F; Hennelly, Christopher M; Aghakhanian, Farhang; Parr, Jonathan B; Claffey, Kevin P; Radolf, Justin D; Hawley, Kelly L; Caimano, Melissa J mBio 2024 Nov;e0325324
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Clinical and genomic diversity of Treponema pallidum subspecies pallidum to inform vaccine research: an international, molecular epidemiology study.
Seña, Arlene C; Matoga, Mitch M; Yang, Ligang; Lopez-Medina, Eduardo; Aghakhanian, Farhang; Chen, Jane S; Bettin, Everton B; Caimano, Melissa J; Chen, Wentao; Garcia-Luna, Jonny A; Hennelly, Christopher M; Jere, Edward; Jiang, Yinbo; Juliano, Jonathan J; Pospíšilová, Petra; Ramirez, Lady; Šmajs, David; Tucker, Joseph D; Vargas Cely, Fabio; Zheng, Heping; Hoffman, Irving F; Yang, Bin; Moody, M Anthony; Hawley, Kelly L; Salazar, Juan C; Radolf, Justin D; Parr, Jonathan B The Lancet. Microbe 2024 Sep;5(9):100871
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Leptospira interrogans encodes a canonical BamA and three novel noNterm Omp85 outer membrane protein paralogs.
Bettin, Everton B; Grassmann, André A; Dellagostin, Odir A; Gogarten, Johann Peter; Caimano, Melissa J Scientific reports 2024 Aug;14(1):19958
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An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms.
Hart, Thomas M; Sonnert, Nicole D; Tang, Xiaotian; Chaurasia, Reetika; Allen, Paige E; Hunt, Jason R; Read, Curtis B; Johnson, Emily E; Arora, Gunjan; Dai, Yile; Cui, Yingjun; Chuang, Yu-Min; Yu, Qian; Rahman, M Sayeedur; Mendes, M Tays; Rolandelli, Agustin; Singh, Pallavi; Tripathi, Abhai K; Ben Mamoun, Choukri; Caimano, Melissa J; Radolf, Justin D; Lin, Yi-Pin; Fingerle, Volker; Margos, Gabriele; Pal, Utpal; Johnson, Raymond M; Pedra, Joao H F; Azad, Abdu F; Salje, Jeanne; Dimopoulos, George; Vinetz, Joseph M; Carlyon, Jason A; Palm, Noah W; Fikrig, Erol; Ring, Aaron M Cell 2024 Jul;187(15):4113-4127.e13
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Clinical presentation of early syphilis and genomic sequences of Treponema pallidum strains in patient specimens and isolates obtained by rabbit inoculation.
Yang, Ligang; Zhang, Xiaohui; Chen, Wentao; Seña, Arlene C; Zheng, Heping; Jiang, Yinbo; Zhao, Peizhen; Chen, Rongyi; Wang, Liuyuan; Ke, Wujian; Salazar, Juan C; Parr, Jonathan B; Tucker, Joseph D; Hawley, Kelly L; Caimano, Melissa J; Hennelly, Christopher M; Aghakanian, Farhang; Bettin, Everton B; Zhang, Feifei; Chen, Jane S; Moody, M Anthony; Radolf, Justin D; Yang, Bin The Journal of infectious diseases 2024 Jun;
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Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia.
Salazar, Juan C; Vargas-Cely, Fabio; García-Luna, Jonny A; Ramirez, Lady G; Bettin, Everton B; Romero-Rosas, Nelson; Amórtegui, María F; Silva, Sebastián; Oviedo, Oscar; Vigil, Julie; La Vake, Carson J; Galindo, Ximena; Ramirez, Jose D; Martínez-Valencia, Alvaro J; Caimano, Melissa J; Hennelly, Christopher M; Aghakhanian, Farhang; Moody, M Anthony; Seña, Arlene C; Parr, Jonathan B; Hawley, Kelly L; López-Medina, Eduardo; Radolf, Justin D PloS one 2024 Jan;19(7):e0307600
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A unique borrelial protein facilitates microbial immune evasion.
Foor, Shelby D; Brangulis, Kalvis; Shakya, Anil K; Rana, Vipin S; Bista, Sandhya; Kitsou, Chrysoula; Ronzetti, Michael; Alreja, Adit B; Linden, Sara B; Altieri, Amanda S; Baljinnyam, Bolormaa; Akopjana, Inara; Nelson, Daniel C; Simeonov, Anton; Herzberg, Osnat; Caimano, Melissa J; Pal, Utpal mBio 2023 Oct;e0213523
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High-resolution microbiome analysis reveals exclusionary Klebsiella species competition in preterm infants at risk for necrotizing enterocolitis.
Coleman, Spencer; Unterhauser, Katrin; Rezaul, Karim; Ledala, Nagender; Lesmes, Stephanie; Caimano, Melissa J; Zhou, Yanjiao; Jackson, Eric; Gratalo, Dawn; Driscoll, Mark D; Matson, Adam P Scientific reports 2023 May;13(1):7893
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BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals.
Grassmann, André A; Tokarz, Rafal; Golino, Caroline; McLain, Melissa A; Groshong, Ashley M; Radolf, Justin D; Caimano, Melissa J The Journal of clinical investigation 2023 Jan;
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Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326).
Ferguson, Mary R; Delgado, Kristina N; McBride, Shannon; Orbe, Isabel C; La Vake, Carson J; Caimano, Melissa J; Mendez, Qiana; Moraes, Trevor F; Schryvers, Anthony B; Moody, M Anthony; Radolf, Justin D; Weiner, Michael P; Hawley, Kelly L Frontiers in immunology 2023 Jan;141222267
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Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis.
Delgado, Kristina N; Montezuma-Rusca, Jairo M; Orbe, Isabel C; Caimano, Melissa J; La Vake, Carson J; Luthra, Amit; Hennelly, Christopher M; Nindo, Fredrick N; Meyer, Jacob W; Jones, Letitia D; Parr, Jonathan B; Salazar, Juan C; Moody, M Anthony; Radolf, Justin D; Hawley, Kelly L mBio 2022 Aug;13(4):e0163922
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Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity.
Ledala, Nagender; Malik, Mishika; Rezaul, Karim; Paveglio, Sara; Provatas, Anthony; Kiel, Aaron; Caimano, Melissa; Zhou, Yanjiao; Lindgren, Jonathan; Krasulova, Kristyna; Illes, Peter; Dvorák, Zdenek; Kortagere, Sandhya; Kienesberger, Sabine; Cosic, Amar; Pöltl, Lisa; Zechner, Ellen L; Ghosh, Subho; Mani, Sridhar; Radolf, Justin D; Matson, Adam P mBio 2022 Jan;e0375221
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The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.
Grassmann, André A; Zavala-Alvarado, Crispin; Bettin, Everton B; Picardeau, Mathieu; Benaroudj, Nadia; Caimano, Melissa J PLoS pathogens 2021 Dec;17(12):e1009078
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PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi.
Groshong, Ashley M; Grassmann, André A; Luthra, Amit; McLain, Melissa A; Provatas, Anthony A; Radolf, Justin D; Caimano, Melissa J PLoS pathogens 2021 Jul;17(7):e1009725
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Levels and Characteristics of mRNAs in Spores of Firmicute Species.
Byrd, Brandon; Camilleri, Emily; Korza, George; Craft, D Levi; Green, Joshua; Rocha Granados, Maria; Mok, Wendy W K; Caimano, Melissa J; Setlow, Peter Journal of bacteriology 2021 May;
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Structural modeling of the Treponema pallidum OMPeome: a roadmap for deconvolution of syphilis pathogenesis and development of a syphilis vaccine.
Hawley, Kelly L; Montezuma-Rusca, Jairo M; Delgado, Kristina N; Singh, Navreeta; Uversky, Vladimir N; Caimano, Melissa J; Radolf, Justin D; Luthra, Amit Journal of bacteriology 2021 May;
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High-Resolution Differentiation of Enteric Bacteria in Premature Infant Fecal Microbiomes Using a Novel rRNA Amplicon.
Graf, J; Ledala, N; Caimano, M J; Jackson, E; Gratalo, D; Fasulo, D; Driscoll, M D; Coleman, S; Matson, A P mBio 2021 Feb;12(1):
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Gene Regulation and Transcriptomics.
Samuels, D Scott; Lybecker, Meghan C; Yang, X Frank; Ouyang, Zhiming; Bourret, Travis J; Boyle, William K; Stevenson, Brian; Drecktrah, Dan; Caimano, Melissa J Current issues in molecular biology 2021 Jan;42223-266
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Cytotoxin-producing Klebsiella oxytoca in the preterm gut and its association with necrotizing enterocolitis.
Paveglio, Sara; Ledala, Nagender; Rezaul, Karim; Lin, Qingqi; Zhou, Yanjiao; Provatas, Anthony A; Bennett, Erin; Lindberg, Tristan; Caimano, Melissa; Matson, Adam P Emerging microbes & infections 2020 Dec;9(1):1321-1329
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The BB0345 hypothetical protein of Borrelia burgdorferi is essential for mammalian infection.
Graham, Danielle E; Groshong, Ashley M; Jackson-Litteken, Clay D; Moore, Brendan P; Caimano, Melissa J; Blevins, Jon S Infection and immunity 2020 Sep;
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Analysis of 5'-NAD capping of mRNAs in dormant spores of Bacillus subtilis.
Craft, D Levi; Korza, George; Zhang, Yaqing; Frindert, Jens; Jäschke, Andres; Caimano, Melissa J; Setlow, Peter FEMS microbiology letters 2020 Sep;367(17):
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Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.*Shared First Authorship
Luthra, Amit; Montezuma-Rusca, Jairo M* ; La Vake, Carson J; LeDoyt, Morgan; Delgado, Kristina N; Davenport, Timothy C; Fiel-Gan, Mary; Caimano, Melissa J; Radolf, Justin D; Hawley, Kelly L. PLoS pathogens 2020 Sep;16(9):e1008871
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Analysis of Treponema pallidum strains from China using improved methods for whole-genome sequencing from primary syphilis chancres.
Chen, Wentao; Šmajs, David; Hu, Yongfei; Ke, Wujian; Pospíšilová, Petra; Hawley, Kelly L; Caimano, Melissa J; Radolf, Justin D; Sena, Arlene; Tucker, Joseph D; Yang, Bin; Juliano, Jonathan J; Zheng, Heping; Parr, Jonathan B The Journal of Infectious Diseases (in press) 2020 Jul;
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Role of glucosyltransferase R in biofilm interactions between Streptococcus oralis and Candida albicans.
Souza, João Gabriel Silva; Bertolini, Martinna; Thompson, Angela; Mansfield, Jillian M; Grassmann, André Alex; Maas, Kendra; Caimano, Melissa J; Barao, Valentim Adelino Ricardo; Vickerman, M Margaret; Dongari-Bagtzoglou, Anna The ISME journal 2020 Feb;
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The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity.
Caimano, Melissa J; Groshong, Ashley M; Belperron, Alexia; Mao, Jialing; Hawley, Kelly L; Luthra, Amit; Graham, Danielle E; Earnhart, Christopher G; Marconi, Richard T; Bockenstedt, Linda K; Blevins, Jon S; Radolf, Justin D Frontiers in microbiology 2019 Sep;101923
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Properties of Aged Spores of Bacillus subtilis.
Camilleri, Emily; Korza, George; Green, Joshua; Yuan, Jianhui; Li, Yong-Qing; Caimano, Melissa J; Setlow, Peter Journal of bacteriology 2019 May;
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Fecal Microbiomes in Premature Infants With and Without Parenteral Nutrition-Associated Cholestasis.
Mokha, Jasmeet S; Davidovics, Zev H; Maas, Kendra; Caimano, Melissa J; Matson, Adam Journal of pediatric gastroenterology and nutrition 2019 Apr;
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Analysis of the Messenger RNAs in Spores of Bacillus subtilis.
Korza, George; Camilleri, Emily; Green, Joshua; Robinson, Janelle; Nagler, Katja; Moeller, Ralf; Caimano, Melissa J; Setlow, Peter Journal of bacteriology 2019 Feb;
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Preterm infant gut microbial patterns related to the development of necrotizing enterocolitis.
Lindberg, Tristan P; Caimano, Melissa J; Hagadorn, James I; Bennett, Erin M; Maas, Kendra; Brownell, Elizabeth A; Matson, Adam P The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2018 Jun;1-10
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Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete.
Kumar, Sanjiv; Caimano, Melissa J; Anand, Arvind; Dey, Abhishek; Hawley, Kelly L; LeDoyt, Morgan E; La Vake, Carson J; Cruz, Adriana R; Ramirez, Lady G; Pašteková, Lenka; Bezsonova, Irina; Šmajs, David; Salazar, Juan C; Radolf, Justin D mBio 2018 Jun;9(3):
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Generation of Mammalian Host-Adapted Borrelia burgdorferi by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats.
Caimano, Melissa J Methods in molecular biology (Clifton, N.J.) 2018 Jan;169035-45
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Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter.
Groshong, Ashley M; Dey, Abhishek; Bezsonova, Irina; Caimano, Melissa J; Radolf, Justin D mBio 2017 Dec;8(6):
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The major outer sheath protein forms distinct conformers and multimeric complexes in the outer membrane and periplasm of Treponema denticola.
Puthenveetil, Robbins; Kumar, Sanjiv; Caimano, Melissa J; Dey, Abhishek; Anand, Arvind; Vinogradova, Olga; Radolf, Justin D Scientific reports 2017 Oct;7(1):13260
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Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete.
Grove, Arianna P; Liveris, Dionysios; Iyer, Radha; Petzke, Mary; Rudman, Joseph; Caimano, Melissa J; Radolf, Justin D; Schwartz, Ira mBio 2017 Aug;8(4):
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IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages.
Hawley, Kelly L; Cruz, Adriana R; Benjamin, Sarah J; La Vake, Carson J; Cervantes, Jorge L; LeDoyt, Morgan; Ramirez, Lady G; Mandich, Daniza; Fiel-Gan, Mary; Caimano, Melissa J; Radolf, Justin D; Salazar, Juan C Frontiers in immunology 2017 Jan;81227
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The Treponema denticola FhbB protein is a dominant early antigen that elicits FhbB variant specific antibodies that block factor H binding and cleavage by dentilisin.
Miller, Daniel P; Oliver, Lee D; Tegels, Brittney K; Reed, Lucas A; O'Bier, Nathaniel; Kurniyati, Kurni; Faust, Lindsay A; Lawson, Christine K; Allard, Anna M; Caimano, Melissa J; Marconi, Richard T Infection and immunity 2016 Apr;842051-2058
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Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
Gulia-Nuss, Monika; Nuss, Andrew B; Meyer, Jason M; Sonenshine, Daniel E; Roe, R Michael; Waterhouse, Robert M; Sattelle, David B; de la Fuente, José; Ribeiro, Jose M; Megy, Karine; Thimmapuram, Jyothi; Miller, Jason R; Walenz, Brian P; Koren, Sergey; Hostetler, Jessica B; Thiagarajan, Mathangi; Joardar, Vinita S; Hannick, Linda I; Bidwell, Shelby; Hammond, Martin P; Young, Sarah; Zeng, Qiandong; Abrudan, Jenica L; Almeida, Francisca C; Ayllón, Nieves; Bhide, Ketaki; Bissinger, Brooke W; Bonzon-Kulichenko, Elena; Buckingham, Steven D; Caffrey, Daniel R; Caimano, Melissa J; Croset, Vincent; Driscoll, Timothy; Gilbert, Don; Gillespie, Joseph J; Giraldo-Calderón, Gloria I; Grabowski, Jeffrey M; Jiang, David; Khalil, Sayed M S; Kim, Donghun; Kocan, Katherine M; Koci, Juraj; Kuhn, Richard J; Kurtti, Timothy J; Lees, Kristin; Lang, Emma G; Kennedy, Ryan C; Kwon, Hyeogsun; Perera, Rushika; Qi, Yumin; Radolf, Justin D; Sakamoto, Joyce M; Sánchez-Gracia, Alejandro; Severo, Maiara S; Silverman, Neal; Šimo, Ladislav; Tojo, Marta; Tornador, Cristian; Van Zee, Janice P; Vázquez, Jesús; Vieira, Filipe G; Villar, Margarita; Wespiser, Adam R; Yang, Yunlong; Zhu, Jiwei; Arensburger, Peter; Pietrantonio, Patricia V; Barker, Stephen C; Shao, Renfu; Zdobnov, Evgeny M; Hauser, Frank; Grimmelikhuijzen, Cornelis J P; Park, Yoonseong; Rozas, Julio; Benton, Richard; Pedra, Joao H F; Nelson, David R; Unger, Maria F; Tubio, Jose M C; Tu, Zhijian; Robertson, Hugh M; Shumway, Martin; Sutton, Granger; Wortman, Jennifer R; Lawson, Daniel; Wikel, Stephen K; Nene, Vishvanath M; Fraser, Claire M; Collins, Frank H; Birren, Bruce; Nelson, Karen E; Caler, Elisabet; Hill, Catherine A Nature Communications 2016 Jan;710507
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Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding.
Bauer, William J; Luthra, Amit; Zhu, Guangyu; Radolf, Justin D; Malkowski, Michael G; Caimano, Melissa J Journal of structural biology 2015 Aug;192(1):48-58
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Generation of Mammalian Host-adapted Leptospira interrogans by Cultivation in Peritoneal Dialysis Membrane Chamber Implantation in Rats.
Grassmann, André Alex; McBride, Alan John Alexander; Nally, Jarlath E; Caimano, Melissa J Bio-protocol 2015 Jul;5(14):
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Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission.
Caimano, Melissa J; Dunham-Ems, Star; Allard, Anna M; Cassera, Maria B; Kenedy, Melisha; Radolf, Justin D Infection and immunity 2015 May;83(8):3043-60
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A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326.
Luthra, Amit; Anand, Arvind; Hawley, Kelly L; LeDoyt, Morgan; La Vake, Carson J; Caimano, Melissa J; Cruz, Adriana R; Salazar, Juan C; Radolf, Justin D Journal of bacteriology 2015 Mar;197(11):1906-20
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Correction for Anand et al., The Major Outer Sheath Protein (Msp) of Treponema denticola Has a Bipartite Domain Architecture and Exists as Periplasmic and Outer Membrane-Spanning Conformers.
Anand, Arvind; Luthra, Amit; Edmond, Maxwell E; LeDoyt, Morgan; Caimano, Melissa J; Radolf, Justin D Journal of bacteriology 2014 Sep;196(18):3361
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Correction for Anand et al., TprC/D (Tp0117/131), a Trimeric, Pore-Forming Rare Outer Membrane Protein of Treponema pallidum, Has a Bipartite Domain Structure.
Anand, Arvind; Luthra, Amit; Dunham-Ems, Star; Caimano, Melissa J; Karanian, Carson; LeDoyt, Morgan; Cruz, Adriana R; Salazar, Juan C; Radolf, Justin D Journal of bacteriology 2014 Sep;196(18):3360
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A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni.
Caimano, Melissa J; Sivasankaran, Sathesh K; Allard, Anna; Hurley, Daniel; Hokamp, Karsten; Grassmann, André A; Hinton, Jay C D; Nally, Jarlath E PLoS pathogens 2014 Mar;10(3):e1004004
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Initial characterization of the FlgE hook high molecular weight complex of Borrelia burgdorferi.
Miller, Kelly A; Motaleb, Md A; Liu, Jun; Hu, Bo; Caimano, Melissa J; Miller, Michael R; Charon, Nyles W PloS one 2014 Jan;9(5):e98338
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HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.
Salman-Dilgimen, Aydan; Hardy, Pierre-Olivier; Radolf, Justin D; Caimano, Melissa J; Chaconas, George PLoS pathogens 2013 Dec;9(12):e1003841
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Sequence divergence in the Treponema denticola FhbB protein and its impact on factor H binding.
Miller, D P; McDowell, J V; Rhodes, D V; Allard, A; Caimano, M; Bell, J K; Marconi, R T Molecular oral microbiology 2013 Aug;28(4):316-30
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The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers.
Anand, Arvind; Luthra, Amit; Edmond, Maxwell E; Ledoyt, Morgan; Caimano, Melissa J; Radolf, Justin D Journal of bacteriology 2013 May;195(9):2060-71
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The β₃-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks.
Ristow, Laura C; Miller, Halli E; Padmore, Lavinia J; Chettri, Rekha; Salzman, Nita; Caimano, Melissa J; Rosa, Patricia A; Coburn, Jenifer Molecular microbiology 2012 Sep;85(6):1105-18
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TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure.
Anand, Arvind; Luthra, Amit; Dunham-Ems, Star; Caimano, Melissa J; Karanian, Carson; LeDoyt, Morgan; Cruz, Adriana R; Salazar, Juan C; Radolf, Justin D Journal of bacteriology 2012 May;194(9):2321-33
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The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue.
Harman, Michael W; Dunham-Ems, Star M; Caimano, Melissa J; Belperron, Alexia A; Bockenstedt, Linda K; Fu, Henry C; Radolf, Justin D; Wolgemuth, Charles W Proceedings of the National Academy of Sciences of the United States of America 2012 Feb;109(8):3059-64
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Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission.
Dunham-Ems, Star M; Caimano, Melissa J; Eggers, Christian H; Radolf, Justin D PLoS pathogens 2012 Feb;8(2):e1002532
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CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi.
Hawley, Kelly L; Olson, Chris M; Iglesias-Pedraz, Juan M; Navasa, Nicolás; Cervantes, Jorge L; Caimano, Melissa J; Izadi, Hooman; Ingalls, Robin R; Pal, Utpal; Salazar, Juan C; Radolf, Justin D; Anguita, Juan Proceedings of the National Academy of Sciences of the United States of America 2012 Jan;109(4):1228-32
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The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices.
Luthra, Amit; Zhu, Guangyu; Desrosiers, Daniel C; Eggers, Christian H; Mulay, Vishwaroop; Anand, Arvind; McArthur, Fiona A; Romano, Fabian B; Caimano, Melissa J; Heuck, Alejandro P; Malkowski, Michael G; Radolf, Justin D The Journal of biological chemistry 2011 Dec;286(48):41656-68
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The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.
Eggers, Christian H; Caimano, Melissa J; Malizia, Robert A; Kariu, Toru; Cusack, Brian; Desrosiers, Daniel C; Hazlett, Karsten R O; Claiborne, Al; Pal, Utpal; Radolf, Justin D Molecular microbiology 2011 Nov;82(3):679-97
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The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks.
Caimano, Melissa J; Kenedy, Melisha R; Kairu, Toru; Desrosiers, Daniel C; Harman, Michael; Dunham-Ems, Star; Akins, Darrin R; Pal, Utpal; Radolf, Justin D Infection and immunity 2011 Aug;79(8):3117-30
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Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle.
Pappas, Christopher J; Iyer, Radha; Petzke, Mary M; Caimano, Melissa J; Radolf, Justin D; Schwartz, Ira PLoS pathogens 2011 Jul;7(7):e1002102
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TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein.
Desrosiers, Daniel C; Anand, Arvind; Luthra, Amit; Dunham-Ems, Star M; LeDoyt, Morgan; Cummings, Michael A D; Eshghi, Azad; Cameron, Caroline E; Cruz, Adriana R; Salazar, Juan C; Caimano, Melissa J; Radolf, Justin D Molecular microbiology 2011 Jun;80(6):1496-515
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BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle.
Banik, Sukalyani; Terekhova, Darya; Iyer, Radha; Pappas, Christopher J; Caimano, Melissa J; Radolf, Justin D; Schwartz, Ira Infection and immunity 2011 Mar;79(3):1208-17
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Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum.
Cox, David L; Luthra, Amit; Dunham-Ems, Star; Desrosiers, Daniel C; Salazar, Juan C; Caimano, Melissa J; Radolf, Justin D Infection and immunity 2010 Dec;78(12):5178-94
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Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars.
Balic, Anamaria; Aguila, H Leonardo; Caimano, Melissa J; Francone, Victor P; Mina, Mina Bone 2010 Jun;46(6):1639-51
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Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi.
Xu, Haijun; Caimano, Melissa J; Lin, Tao; He, Ming; Radolf, Justin D; Norris, Steven J; Gherardini, Frank; Gheradini, Frank; Wolfe, Alan J; Yang, X Frank PLoS pathogens 2010 Jan;6(9):e1001104
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Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks.
Dunham-Ems, Star M; Caimano, Melissa J; Pal, Utpal; Wolgemuth, Charles W; Eggers, Christian H; Balic, Anamaria; Radolf, Justin D The Journal of clinical investigation 2009 Dec;119(12):3652-65
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Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta.
Salazar, Juan C; Duhnam-Ems, Star; La Vake, Carson; Cruz, Adriana R; Moore, Meagan W; Caimano, Melissa J; Velez-Climent, Leonor; Shupe, Jonathan; Krueger, Winfried; Radolf, Justin D PLoS pathogens 2009 May;5(5):e1000444
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Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals.
Mulay, Vishwaroop B; Caimano, Melissa J; Iyer, Radha; Dunham-Ems, Star; Liveris, Dionysios; Petzke, Mary M; Schwartz, Ira; Radolf, Justin D Journal of bacteriology 2009 Apr;191(8):2783-94
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NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi.
Tupin, Emmanuel; Benhnia, Mohammed Rafii-El-Idrissi; Kinjo, Yuki; Patsey, Rebeca; Lena, Christopher J; Haller, Matthew C; Caimano, Melissa J; Imamura, Masakazu; Wong, Chi-Huey; Crotty, Shane; Radolf, Justin D; Sellati, Timothy J; Kronenberg, Mitchell Proceedings of the National Academy of Sciences of the United States of America 2008 Dec;105(50):19863-8
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MicroCommentary: The long strange trip of Borrelia burgdorferi OspC.
Radolf JD and Caimano MJ. Mol Micro 2008 Jan;69(1):1-4
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Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle.
Caimano, Melissa J; Iyer, Radha; Eggers, Christian H; Gonzalez, Cynthia; Morton, Elizabeth A; Gilbert, Michael A; Schwartz, Ira; Radolf, Justin D Molecular microbiology 2007 Sep;65(5):1193-217
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Borrelia burgdorferi BBA74, a periplasmic protein associated with the outer membrane, lacks porin-like properties.
Mulay, Vishwaroop; Caimano, Melissa J; Liveris, Dionysios; Desrosiers, Daniel C; Radolf, Justin D; Schwartz, Ira Journal of bacteriology 2007 Mar;189(5):2063-8
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Sigma factor selectivity in Borrelia burgdorferi: RpoS recognition of the ospE/ospF/elp promoters is dependent on the sequence of the -10 region.
Eggers, Christian H; Caimano, Melissa J; Radolf, Justin D Molecular microbiology 2006 Mar;59(6):1859-75
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Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes.
Caimano, Melissa J; Eggers, Christian H; Gonzalez, Cynthia A; Radolf, Justin D Journal of bacteriology 2005 Nov;187(22):7845-52
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Cultivation of Borrelia burgdorferi in dialysis membrane chambers in rat peritonea.
Caimano, Melissa J Current protocols in microbiology 2005 Jul;Chapter 12Unit 12C.3
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Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease.
Benhnia, Mohammed Rafii-El-Idrissi; Wroblewski, Danielle; Akhtar, Muhammad Naveed; Patel, Raina A; Lavezzi, Wendy; Gangloff, Sophie C; Goyert, Sanna M; Caimano, Melissa J; Radolf, Justin D; Sellati, Timothy J Journal of immunology (Baltimore, Md. : 1950) 2005 Feb;174(3):1539-48
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Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes.
Eggers, Christian H; Caimano, Melissa J; Radolf, Justin D Journal of bacteriology 2004 Nov;186(21):7390-402
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RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants.
Caimano, Melissa J; Eggers, Christian H; Hazlett, Karsten R O; Radolf, Justin D Infection and immunity 2004 Nov;72(11):6433-45
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Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle.
Grimm, Dorothee; Eggers, Christian H; Caimano, Melissa J; Tilly, Kit; Stewart, Philip E; Elias, Abdallah F; Radolf, Justin D; Rosa, Patricia A Infection and immunity 2004 Oct;72(10):5938-46
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The luxS gene is not required for Borrelia burgdorferi tick colonization, transmission to a mammalian host, or induction of disease.
Blevins, Jon S; Revel, Andrew T; Caimano, Melissa J; Yang, Xiaofeng F; Richardson, James A; Hagman, Kayla E; Norgard, Michael V Infection and immunity 2004 Aug;72(8):4864-7
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Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA.
Liang, Fang Ting; Caimano, Melissa J; Radolf, Justin D; Fikrig, Erol Microbial pathogenesis 2004 Jul;37(1):35-40
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Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans.
Salazar, Juan C; Pope, Constance D; Sellati, Timothy J; Feder, Henry M; Kiely, Thomas G; Dardick, Kenneth R; Buckman, Ronald L; Moore, Meagan W; Caimano, Melissa J; Pope, Jonathan G; Krause, Peter J; Radolf, Justin D Journal of immunology (Baltimore, Md. : 1950) 2003 Sep;171(5):2660-70
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Molecular characterization of the presence of Eubacterium spp and Streptococcus spp in endodontic infections.
Fouad, A F; Kum, K-Y; Clawson, M L; Barry, J; Abenoja, C; Zhu, Q; Caimano, M; Radolf, J D Oral microbiology and immunology 2003 Aug;18(4):249-55
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A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host.
Purser, Joye E; Lawrenz, Matthew B; Caimano, Melissa J; Howell, Jerrilyn K; Radolf, Justin D; Norris, Steven J Molecular microbiology 2003 May;48(3):753-64
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Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays.
Ojaimi, Caroline; Brooks, Chad; Casjens, Sherwood; Rosa, Patricia; Elias, Abdallah; Barbour, Alan; Jasinskas, Algis; Benach, Jorge; Katona, Laura; Radolf, Justin; Caimano, Melissa; Skare, Jon; Swingle, Kristen; Akins, Darrin; Schwartz, Ira Infection and immunity 2003 Apr;71(4):1689-705
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Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding.
Parveen, Nikhat; Caimano, Melissa; Radolf, Justin D; Leong, John M Molecular microbiology 2003 Mar;47(5):1433-44
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Characterization of the stringent response and rel(Bbu) expression in Borrelia burgdorferi.
Bugrysheva, Julia; Dobrikova, Elena Y; Sartakova, Marina L; Caimano, Melissa J; Daniels, Thomas J; Radolf, Justin D; Godfrey, Henry P; Cabello, Felipe C Journal of bacteriology 2003 Feb;185(3):957-65
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Environmental regulation and differential production of members of the Bdr protein family of Borrelia burgdorferi.
Roberts, David M; Caimano, Melissa; McDowell, John; Theisen, Michael; Holm, Arne; Orff, Edward; Nelson, David; Wikel, Stephen; Radolf, Justin; Marconi, Richard T Infection and immunity 2002 Dec;70(12):7033-41
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PCR-based identification of bacteria associated with endodontic infections.
Fouad, Ashraf F; Barry, Jody; Caimano, Melissa; Clawson, Michael; Zhu, Qiang; Carver, Rachaele; Hazlett, Karsten; Radolf, Justin D Journal of clinical microbiology 2002 Sep;40(9):3223-31
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Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background.
Elias, Abdallah F; Stewart, Philip E; Grimm, Dorothee; Caimano, Melissa J; Eggers, Christian H; Tilly, Kit; Bono, James L; Akins, Darrin R; Radolf, Justin D; Schwan, Tom G; Rosa, Patricia Infection and immunity 2002 Apr;70(4):2139-50
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Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the lyme disease spirochaete.
Eggers, Christian H; Caimano, Melissa J; Clawson, Michael L; Miller, William G; Samuels, D Scott; Radolf, Justin D Molecular microbiology 2002 Jan;43(2):281-95
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Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals.
Hefty, P S; Jolliff, S E; Caimano, M J; Wikel, S K; Radolf, J D; Akins, D R Infection and immunity 2001 Jun;69(6):3618-27
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The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity.
Hazlett, K R; Sellati, T J; Nguyen, T T; Cox, D L; Clawson, M L; Caimano, M J; Radolf, J D The Journal of experimental medicine 2001 May;193(9):1015-26
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Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks.
Hagman, K E; Yang, X; Wikel, S K; Schoeler, G B; Caimano, M J; Radolf, J D; Norgard, M V Infection and immunity 2000 Aug;68(8):4759-64
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Isolation and molecular cloning of a secreted immunosuppressant protein from Dermacentor andersoni salivary gland.
Bergman, D K; Palmer, M J; Caimano, M J; Radolf, J D; Wikel, S K The Journal of parasitology 2000 Jun;86(3):516-25
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Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase.
Hardy, G G; Caimano, M J; Yother, J Journal of bacteriology 2000 Apr;182(7):1854-63
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Molecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297.
Caimano, M J; Yang, X; Popova, T G; Clawson, M L; Akins, D R; Norgard, M V; Radolf, J D Infection and immunity 2000 Mar;68(3):1574-86
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Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family.
Yang, X; Popova, T G; Hagman, K E; Wikel, S K; Schoeler, G B; Caimano, M J; Radolf, J D; Norgard, M V Infection and immunity 1999 Nov;67(11):6008-18
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Activation of human monocytic cells by Borrelia burgdorferi and Treponema pallidum is facilitated by CD14 and correlates with surface exposure of spirochetal lipoproteins.
Sellati, T J; Bouis, D A; Caimano, M J; Feulner, J A; Ayers, C; Lien, E; Radolf, J D Journal of immunology (Baltimore, Md. : 1950) 1999 Aug;163(4):2049-56
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The Treponema denticola major sheath protein is predominantly periplasmic and has only limited surface exposure.
Caimano, M J; Bourell, K W; Bannister, T D; Cox, D L; Radolf, J D Infection and immunity 1999 Aug;67(8):4072-83
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Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides.
Akins, D R; Caimano, M J; Yang, X; Cerna, F; Norgard, M V; Radolf, J D Infection and immunity 1999 Mar;67(3):1526-32